Time and place specific policies for controlling ozone precursor nitrogen oxides in New England's electric power sector

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1994.Includes bibliographical references (p. 99-100).by Jeffrey Scott Goldman.M.S

Habitable Exoplanet Observatory (HabEx)

The Habitable-Exoplanet Observatory (HabEx) is a candidate flagship mission being studied by NASA and the astrophysics community in preparation of the 2020 Decadal Survey. The first HabEx mission concept that has been studied is a large (~4m) diffraction-limited optical space telescope, providing unprecedented resolution and contrast in the optical, with extensions into the near ulttraviolet and near infrared domains. We report here on our team’s efforts in defining a scientifically compelling HabEx mission that is technologically executable, affordable within NASA’s expected budgetary envelope, and timely for the next decade. We also briefly discuss our plans to explore less ambitious, descoped missions relative to the primary mission architecture discussed here

The Security imaginary: Explaining military isomorphism

This article proposes the notion of a security imaginary as a heuristic tool for exploring military isomorphism (the phenomenon that weapons and military strategies begin to look the same across the world) at a time when the US model of defence transformation is being adopted by an increasing number of countries. Built on a critical constructivist foundation, the security-imaginary approach is contrasted with rationalist and neo-institutionalist ways of explaining military diffusion and emulation. Merging cultural and constructivist themes, the article offers a ‘strong cultural’ argument to explain why a country would emulate a foreign military model and how this model is constituted in and comes to constitute a society’s security imaginary.Web of Scienc

Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling

Long COVID, a type of post-acute sequelae of SARS-CoV-2 (PASC), has been associated with sustained elevated levels of immune activation and inflammation. However, the mechanisms that drive this inflammation remain unknown. Inflammation during acute coronavirus disease 2019 could be exacerbated by microbial translocation (from the gut and/or lung) to blood. Whether microbial translocation contributes to inflammation during PASC is unknown. We did not observe a significant elevation in plasma markers of bacterial translocation during PASC. However, we observed higher levels of fungal translocation - measured as β-glucan, a fungal cell wall polysaccharide - in the plasma of individuals experiencing PASC compared with those without PASC or SARS-CoV-2-negative controls. The higher β-glucan correlated with higher inflammation and elevated levels of host metabolites involved in activating N-methyl-d-aspartate receptors (such as metabolites within the tryptophan catabolism pathway) with established neurotoxic properties. Mechanistically, β-glucan can directly induce inflammation by binding to myeloid cells (via Dectin-1) and activating Syk/NF-κB signaling. Using a Dectin-1/NF-κB reporter model, we found that plasma from individuals experiencing PASC induced higher NF-κB signaling compared with plasma from negative controls. This higher NF-κB signaling was abrogated by piceatannol (Syk inhibitor). These data suggest a potential targetable mechanism linking fungal translocation and inflammation during PASC

The Habitable Exoplanet (HabEx) Imaging Mission: preliminary science drivers and technical requirements

HabEx is one of four candidate flagship missions being studied in detail by NASA, to be submitted for consideration to the 2020 Decadal Survey in Astronomy and Astrophysics for possible launch in the 2030s. It will be optimized for direct imaging and spectroscopy of potentially habitable exoplanets, and will also enable a wide range of general astrophysics science. HabEx aims to fully characterize planetary systems around nearby solar-type stars for the first time, including rocky planets, possible water worlds, gas giants, ice giants, and faint circumstellar debris disks. In particular, it will explore our nearest neighbors and search for signs of habitability and biosignatures in the atmospheres of rocky planets in the habitable zones of their parent stars. Such high spatial resolution, high contrast observations require a large (roughly greater than 3.5m), stable, and diffraction-limited optical space telescope. Such a telescope also opens up unique capabilities for studying the formation and evolution of stars and galaxies. We present some preliminary science objectives identified for HabEx by our Science and Technology Definition Team (STDT), together with a first look at the key challenges and design trades ahead

Habitable Exoplanet Observatory (HabEx)

The Habitable-Exoplanet Observatory (HabEx) is a candidate flagship mission being studied by NASA and the astrophysics community in preparation of the 2020 Decadal Survey. The first HabEx mission concept that has been studied is a large (~4m) diffraction-limited optical space telescope, providing unprecedented resolution and contrast in the optical, with extensions into the near ulttraviolet and near infrared domains. We report here on our team’s efforts in defining a scientifically compelling HabEx mission that is technologically executable, affordable within NASA’s expected budgetary envelope, and timely for the next decade. We also briefly discuss our plans to explore less ambitious, descoped missions relative to the primary mission architecture discussed here

A Novel Role for the NLRC4 Inflammasome in Mucosal Defenses against the Fungal Pathogen Candida albicans

Candida sp. are opportunistic fungal pathogens that colonize the skin and oral cavity and, when overgrown under permissive conditions, cause inflammation and disease. Previously, we identified a central role for the NLRP3 inflammasome in regulating IL-1β production and resistance to dissemination from oral infection with Candida albicans. Here we show that mucosal expression of NLRP3 and NLRC4 is induced by Candida infection, and up-regulation of these molecules is impaired in NLRP3 and NLRC4 deficient mice. Additionally, we reveal a role for the NLRC4 inflammasome in anti-fungal defenses. NLRC4 is important for control of mucosal Candida infection and impacts inflammatory cell recruitment to infected tissues, as well as protects against systemic dissemination of infection. Deficiency in either NLRC4 or NLRP3 results in severely attenuated pro-inflammatory and antimicrobial peptide responses in the oral cavity. Using bone marrow chimeric mouse models, we show that, in contrast to NLRP3 which limits the severity of infection when present in either the hematopoietic or stromal compartments, NLRC4 plays an important role in limiting mucosal candidiasis when functioning at the level of the mucosal stroma. Collectively, these studies reveal the tissue specific roles of the NLRP3 and NLRC4 inflammasome in innate immune responses against mucosal Candida infection

Detailed Analysis of a Contiguous 22-Mb Region of the Maize Genome

Most of our understanding of plant genome structure and evolution has come from the careful annotation of small (e.g., 100 kb) sequenced genomic regions or from automated annotation of complete genome sequences. Here, we sequenced and carefully annotated a contiguous 22 Mb region of maize chromosome 4 using an improved pseudomolecule for annotation. The sequence segment was comprehensively ordered, oriented, and confirmed using the maize optical map. Nearly 84% of the sequence is composed of transposable elements (TEs) that are mostly nested within each other, of which most families are low-copy. We identified 544 gene models using multiple levels of evidence, as well as five miRNA genes. Gene fragments, many captured by TEs, are prevalent within this region. Elimination of gene redundancy from a tetraploid maize ancestor that originated a few million years ago is responsible in this region for most disruptions of synteny with sorghum and rice. Consistent with other sub-genomic analyses in maize, small RNA mapping showed that many small RNAs match TEs and that most TEs match small RNAs. These results, performed on ∼1% of the maize genome, demonstrate the feasibility of refining the B73 RefGen_v1 genome assembly by incorporating optical map, high-resolution genetic map, and comparative genomic data sets. Such improvements, along with those of gene and repeat annotation, will serve to promote future functional genomic and phylogenomic research in maize and other grasses