2,908 research outputs found
A comparison of methods for the registration of tractographic fibre images
Diffusion tensor imaging (DTI) and tractography have opened up new avenues in neuroscience. As most applications require precise spatial localization of the fibre images, image registration is an important area of research. Registration is usually performed prior to tractography. However more reliable images could be produced if a viable registration can be performed post tractography. This study shows two available techniques for direct registration of fibre images and explores novel adaptations of these. The methods register volume images derived from the fibres, and reapply the transformation from these registrations to the fibre images. The first method is a local affine registration and the second is a global affine registration. The local affine method produced superior results
Revisiting the reaction of hydroxyl radicals with vicinal diols in water
The carbonyl products of the reactions of hydroxyl radicals with three vicinal diols (ethane-1,2-diol, propane-1,2-diol and butane-2,3-diol) have been identified and quantified. Hydroxyl radicals were produced by gamma-radiolysis of N2O-saturated aqueous solutions. The reactions result in the formation of alkoxyl radicals (15%) followed by beta-fragmentation, and alpha-hydroxyl alkyl radicals that undergo H2O elimination. The latter process is part of a radical chain reaction at higher diol concentrations.Fil: Jiang, Dong. University of Newcastle; Reino UnidoFil: Barata Vallejo, Sebastian. Universidad de Buenos Aires. Facultad de Farmacia y BioquÃmica. Departamento de QuÃmica Orgánica. Cátedra de QuÃmica Orgánica I; ArgentinaFil: Golding, Bernard T.. University of Newcastle; Reino UnidoFil: Ferreri, Carla. Consiglio Nazionale delle Ricerche; ItaliaFil: Chatgilialoglu, Chryssostomos. Consiglio Nazionale delle Ricerche; Itali
Trends in International Maths and Science Study (TIMSS) 2019 National Report for England
The Trends in International Mathematics and Science Study (TIMSS) is a survey of the educational achievement of pupils in years 5 and 9 organised by the International Association for the Evaluation of Educational Achievement (IEA).
The report provides analysis of the TIMSS 2019 findings for England and compares England’s performance to performance in other participating countries
Living apart, losing sympathy? How neighbourhood context affects attitudes to redistribution and to welfare recipients
Rising levels of income inequality have been directly linked to rising levels of spatial segregation. In this paper, we explore whether rising segregation may in turn erode support for the redistributive policies of the welfare state, further increasing levels of inequality – a form of positive feedback. The role of the neighbourhood has been neglected in attitudes research but, building on both political geography and ‘neighbourhood effects’ literatures, we theorise that neighbourhood context may shape attitudes through the transmission of attitudes directly and through the accumulation of relevant knowledge. We test this through multilevel modelling of data from England on individual attitudes to redistribution in general and to welfare benefit recipients in particular. We show that the individual factors shaping these attitudes are quite different and that the influence of neighbourhood context also varies as a result. The findings support the idea that neighbourhood context shapes attitudes, with the knowledge accumulation mechanism likely to be the more important. Rising spatial segregation would appear to erode support for redistribution but to increase support for welfare recipients – at least in a context where the dominant media discourse presents such a stigmatising image of those on welfare benefits
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.
The ability of the potent poly(ADP-ribose) polymerase (PARP) inhibitor, NU1025 (8-hydroxy-2-methyl-quinazolin-4-[3H]one) to potentiate the cytotoxicity of a panel of mechanistically diverse anti-cancer agents was evaluated in L1210 cells. NU1025 enhanced the cytotoxicity of the DNA-methylating agent MTIC, gamma-irradiation and bleomycin 3.5-, 1.4- and 2-fold respectively. The cytotoxicities of the thymidylate synthase inhibitor, nolatrexed, and the cytotoxic nucleoside, gemcitabine, were not increased. Potentiation of MTIC cytotoxicity by a delayed exposure to NU1025 was equally effective as by a simultaneous exposure to NU1025, indicating that the effects of NU1025 were mediated by an inhibition of the cellular recovery. The recovery from potentially lethal gamma-irradiation damage cytotoxicity in plateau-phase cells was also inhibited by NU1025. Investigation of DNA strand breakage and repair in gamma-irradiated cells by alkaline elution demonstrated that NU1025 caused a marked retardation of DNA repair. A structurally different PARP inhibitor, NU1064 (2-methylbenzimidazole-4-carboxamide), also potentiated the cytotoxicity of MTIC, to a similar extent to NU1025. NU1064 potentiated a sublethal concentration of a DNA methylating agent in a concentration-dependent manner. Collectively, these data suggest that the most suitable cytotoxic agents for use in combination with PARP inhibitors are methylating agents, bleomycin and ionizing radiation, but not anti-metabolites
Dynamics of Tunneling Centers in Metallic Systems
Dynamics of tunneling centers (TC) in metallic systems is studied, using the
technique of bosonization. The interaction of the TC with the conduction
electrons of the metal involves two processes, namely, the screening of the TC
by electrons, and the so-called electron assisted tunneling. The presence of
the latter process leads to a different form of the renormalized tunneling
frequency of the TC, and the tunneling motion is damped with a temperature
dependent relaxation rate. As the temperature is lowered, the relaxation rate
per temperature shows a steep rise as opposed to that in the absence of
electron assisted process. It is expected that this behavior should be observed
at very low temperatures in a careful experiment. The present work thus tries
to go beyond the existing work on the {\it dynamics} of a two-level system in
metals, by treating the electron assisted process.Comment: REVTeX twocolumn format, 5 pages, two PostScript figures available on
request. Preprint # : imsc 94/3
Scaling and universality in the anisotropic Kondo model and the dissipative two-state system
Scaling and universality in the Ohmic two-state system is investigated by
exploiting the equivalence of this model to the anisotropic Kondo model. For
the Ohmic two-state system, we find universal scaling functions for the
specific heat, , static susceptibility, , and
spin relaxation function depending on the reduced
temperature (frequency ), with
the renormalized tunneling frequency, and uniquely specified by the dissipation
strength (). The scaling functions can be used to extract
and in experimental realizations.Comment: 5 pages (LaTeX), 4 EPS figures. Minor changes, typos corrected,
journal reference adde
Luminous Infrared Galaxies with the Submillimeter Array: I. Survey Overview and the Central Gas to Dust Ratio
We present new data obtained with the Submillimeter Array for a sample of
fourteen nearby luminous and ultraluminous infrared galaxies. The galaxies were
selected to have luminosity distances D < 200 Mpc and far-infrared luminosities
log(L_FIR) > 11.4. The galaxies were observed with spatial resolutions of order
1 kpc in the CO J=3-2, CO J=2-1, 13CO J=2-1, and HCO+ J=4-3 lines as well as
the continuum at 880 microns and 1.3 mm. We have combined our CO and continuum
data to measure an average gas-to-dust mass ratio of 120 +/- 28 (rms deviation
109) in the central regions of these galaxies, very similar to the value of 150
determined for the Milky Way. This similarity is interesting given the more
intense heating from the starburst and possibly accretion activity in the
luminous infrared galaxies compared to the Milky Way. We find that the peak H_2
surface density correlates with the far-infrared luminosity, which suggests
that galaxies with higher gas surface densities inside the central kiloparsec
have a higher star formation rate. The lack of a significant correlation
between total H_2 mass and far-infrared luminosity in our sample suggests that
the increased star formation rate is due to the increased availability of
molecular gas as fuel for star formation in the central regions. In contrast to
previous analyses by other authors, we do not find a significant correlation
between central gas surface density and the star formation efficiency, as trace
by the ratio of far-infrared luminosity to nuclear gas mass. Our data show that
it is the star formation rate, not the star formation efficiency, that
increases with increasing central gas surface density in these galaxies.Comment: 66 pages, 39 figures, aastex preprint format; to be published in ApJ
Supplements. Version of paper with full resolution figures available at
http://www.physics.mcmaster.ca/~wilson/www_xfer/ULIRGS_publi
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