Thermophysical properties of sodium

Assessment is given of physical and thermodynamic properties of sodium. FORTRAN subroutine computes enthalphy and entropy of sodium in given state, and composition, molecular weight, volume, and compressibility factor of corresponding vapor. Tabular results for saturated liquid and vapor are presented for a 500-2500 degree F range

Web-based Tools for the Analysis of DNA Microarrays

End of project reportDNA microarrays are widely used for gene expression profiling. Raw data resulting from microarray experiments, however, tends to be very noisy and there are many sources of technical variation and bias. This raw data needs to be quality assessed and interactively preprocessed to minimise variation before statistical analysis in order to achieve meaningful result. Therefore microarray analysis requires a combination of visualisation and statistical tools, which vary depending on what microarray platform or experimental design is used.Bioconductor is an existing open source software project that attempts to facilitate analysis of genomic data. It is a collection of packages for the statistical programming language R. Bioconductor is particularly useful in analyzing microarray experiments. The problem is that the R programming language’s command line interface is intimidating to many users who do not have a strong background in computing. This often leads to a situation where biologists will resort to using commercial software which often uses antiquated and much less effective statistical techniques, as well as being expensively priced. This project aims to bridge this gap by providing a user friendly web-based interface to the cutting edge statistical techniques of Bioconductor

Kinerja Portofolio Optimal Berdasarkan Model Indeks Tunggal

Tujuan penelitian ini adalah untuk mengetahui bagaimana kinerja portofolio optimal pada sektor basic industry and chemicals dan sektor trade, service, and investment pada Januari 2015 hingga Januari 2016 sebagai 2 sektor yang memiliki koefisien korelasi terendah antar sektor. Penelitian ini dilakukan di Perusahaan yang terdaftar di BEI dan tergabung dalam sektor basic industry and chemicals dan sektor trade, service, and investment. Jumlah sampel yang di ambil sebanyak 173 Perusahaan, dengan metode sampling sensus. Pengumpulan data dilakukan dengan cara observasi non perilaku. Berdasarkan hasil perhitungan ditemukan bahwa terdapat 2 saham optimal pada masing-masing sektor yang selanjutnya di silang menjadi portofolio A, B, C, dan D. Setelah melakukan pengukuran kinerja untuk diperingkat didapatkan portofolio C dengan kinerja terbaik yang memberikan return yang lebih tinggi pada tingkat risiko sistematis yang relatif sama dibandingkan portofolio lainnya

Energy balance criteria for viscoelastic fracture

An energy balance criterion of the Griffith type has been used to derive conditions that are valid, in the isothermal non-inertial approximation, for the growth of cracks in viscoelastic bodies. These bodies are acted upon by general position and time-dependent load. The conditions obtained have the same form as the instability conditions obtained for the corresponding problems in elasticity theory and, in particular are independent of crack velocity. The analysis relies upon an exact calculation of the displacement and stress fields that is derived in the appendix with the aid of extensions to viscoelasticity of the Kolosov-Muskhelishvili equations of elasticity theory

Strong Tunneling in Double-Island Structures

We study the electron transport through a system of two low-capacitance metal islands connected in series between two electrodes. The work is motivated in part by experiments on semiconducting double-dots, which show intriguing effects arising from coherent tunneling of electrons and mixing of the single-electron states across tunneling barriers. In this article, we show how coherent tunneling affects metallic systems and leads to a mixing of the macroscopic charge states across the barriers. We apply a recently formulated RG approach to examine the linear response of the system with high tunnel conductances (up to 8e^2/h). In addition we calculate the (second order) cotunneling contributions to the non-linear conductance. Our main results are that the peaks in the linear and nonlinear conductance as a function of the gate voltage are reduced and broadened in an asymmetric way, as well as shifted in their positions. In the limit where the two islands are coupled weakly to the electrodes, we compare to theoretical results obtained by Golden and Halperin and Matveev et al. In the opposite case when the two islands are coupled more strongly to the leads than to each other, the peaks are found to shift, in qualitative agreement with the recent prediction of Andrei et al. for a similar double-dot system which exhibits a phase transition.Comment: 12 page

Odor sampling strategies in mice with genetically altered olfactory responses

Peripheral sensory cells and the central neuronal circuits that monitor environmental changes to drive behaviors should be adapted to match the behaviorally relevant kinetics of incoming stimuli, be it the detection of sound frequencies, the speed of moving objects or local temperature changes. Detection of odorants begins with the activation of olfactory receptor neurons in the nasal cavity following inhalation of air and airborne odorants carried therein. Thus, olfactory receptor neurons are stimulated in a rhythmic and repeated fashion that is determined by the breathing or sniffing frequency that can be controlled and altered by the animal. This raises the question of how the response kinetics of olfactory receptor neurons are matched to the imposed stimulation frequency and if, vice versa, the kinetics of olfactory receptor neuron responses determine the sniffing frequency. We addressed this question by using a mouse model that lacks the K+-dependent Na+/Ca2+ exchanger 4 (NCKX4), which results in markedly slowed response termination of olfactory receptor neuron responses and hence changes the temporal response kinetics of these neurons. We monitored sniffing behaviors of freely moving wildtype and NCKX4 knockout mice while they performed olfactory Go/NoGo discrimination tasks. Knockout mice performed with similar or, surprisingly, better accuracy compared to wildtype mice, but chose, depending on the task, different odorant sampling durations depending on the behavioral demands of the odorant identification task. Similarly, depending on the demands of the behavioral task, knockout mice displayed a lower basal breathing frequency prior to odorant sampling, a possible mechanism to increase the dynamic range for changes in sniffing frequency during odorant sampling. Overall, changes in sniffing behavior between wildtype and NCKX4 knockout mice were subtle, suggesting that, at least for the particular odorant-driven task we used, slowed response termination of the odorant-induced receptor neuron response either has a limited detrimental effect on odorant-driven behavior or mice are able to compensate via an as yet unknown mechanism

Dynamics of odor sampling strategies in mice

Mammalian olfactory receptor neurons in the nasal cavity are stimulated by odorants carried by the inhaled air and their activation is therefore tied to and driven by the breathing or sniffing frequency. Sniffing frequency can be deliberately modulated to alter how odorants stimulate olfactory receptor neurons, giving the animal control over the frequency of odorant exposure to potentially aid odorant detection and discrimination. We monitored sniffing behaviors and odorant discrimination ability of freely-moving mice while they sampled either decreasing concentrations of target odorants or sampled a fixed target odorant concentration in the presence of a background of increasing odorant concentrations, using a Go-NoGo behavioral paradigm. This allowed us to ask how mice alter their odorant sampling duration and sampling (sniffing) frequency depending on the demands of the task and its difficulty. Mice showed an anticipatory increase in sniffing rate prior to odorant exposure and chose to sample for longer durations when exposed to odorants as compared to the solvent control odorant. Similarly, mice also took more odorant sampling sniffs when exposed to target odorants compared to the solvent control odorant. In general, odorant sampling strategies became more similar the more difficult the task was, e.g. the lower the target odorant concentration or the lower the target odorant contrast relative to the background odorant, suggesting that sniffing patterns are not preset, but are dynamically modulated by the particular task and its difficulty

Antimatter research in Space

Two of the most compelling issues facing astrophysics and cosmology today are to understand the nature of the dark matter that pervades the universe and to understand the apparent absence of cosmological antimatter. For both issues, sensitive measurements of cosmic-ray antiprotons and positrons, in a wide energy range, are crucial. Many different mechanisms can contribute to antiprotons and positrons production, ranging from conventional reactions up to exotic processes like neutralino annihilation. The open problems are so fundamental (i.e.: is the universe symmetric in matter and antimatter ?) that experiments in this field will probably be of the greatest interest in the next years. Here we will summarize the present situation, showing the different hypothesis and models and the experimental measurements needed to lead to a more established scenario.Comment: 10 pages, 7 figures, Invited talk at the 18th European Cosmic Ray Symposium, Moscow, July 2002, submitted to Journal of Physics