Studies on Some Compounds of Medicinal Interest

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Cultivation and characteristics of the Marine Actinobacteria from the Sea water of Alang, Bhavnagar

1896-1901The methods for the sample treatment and isolation included heat and CaCO3 treatment, enrichment of the samples and use of different growth media. Since the initial microbial load was quite high, the serial dilutions were used for the isolation of the actinomycetes. Morphotypes of different colony morphology and filamentous structure were detected and selected. A distinct variation in the occurrence of the morphotypes on various media using different techniques was evident. Among the three seasons; winter samples had highest number of the morphotypes. The heat treatment of the samples significantly affected the isolation and abundance of the morphotypes. Further, highest numbers of the actinomycetes were obtained on ISP-3 (International Streptomyces Project; Oatmeal agar), ISP-6 (Peptone-yeast extract iron agar) and ISP-2 (Yeast extract-malt extract agar) media, suggesting its suitability for the growth of the marine actinomycetes. Over all, the study highlights the occurrence, cultivability and diversity of the actinomycetes of the Alang Sea water

Unveiling Advanced Computational Applications in Quantum Computing: A Comprehensive Review

The field of advanced computing applications could experience a significant impact from quantum computing, which is a rapidly developing field with the potential to revolutionize numerous areas of science and technology. In this review, we explore into the various ways in which complex computational problems could be tackled by utilizing quantum computers, including machine learning, optimization, and simulation. One potential application of quantum computers is in machine learning, where they could be used to improve the accuracy and efficiency of algorithms. Complex optimization problems, such as those encountered in logistics and finance, can be addressed using quantum computers as well. Furthermore, the utilization of quantum computers could enable the simulation of intricate systems, such as molecules and materials, leading to significant applications in fields like Physics and Material Technology. Although quantum computers are currently in the early stages of development, they possess the potential to propel numerous areas of science and technology forward in a significant manner. Further research and development are needed to fully realize the potential of quantum computing in the field of advanced computing applications

Theoretical study of pressure dependence of superconducting state parameters of some metals using pseudopotential approach

In the present theoretical study, we have calculated superconducting state parameters (SSPs) viz; electron-phonon coupling strength (λ), Coulomb pseudopotential (µ*), critical temperature (Tc), effective interaction strength (N0V) and isotopic effect parameter ( α) of some polyvalent metals (Pb, Ga, In, Sn and Tl) using well-established structured local pseudopotential due to Fiolhais et al. (1995). The pseudopotential with its individual set of parameters has been found to be good in predicting transition temperature Tc for all the metals. Looking to such success, we have extended the present model for the theoretical study of pressure dependence of transition temperature Tc using Debye- Gruneisen model. Our predicted critical volumes using different approaches are well agreed with each other and also with other reported findings. Thus, the present model is consistent and better than nonlocal norm conserving pseudopotentials because it is found to be transferable without any kind of adjustment of its parameters along with its simplicity and predictivity

TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death

Emerging evidence suggests that ubiquitin mediated post translational modification is a critical regulatory process involved in diverse cellular pathways including cell death. During ubiquitination, E3 ligases recognize target proteins and determine the topology of ubiquitin chains. Recruitment of E3 ligases to targets proteins under stress conditions including oxidative stress and their implication in cell death have not been systemically explored. In the present study, we characterized the role of TRIM32 as an E3 ligase in regulation of oxidative stress induced cell death. TRIM32 is ubiquitously expressed in cell lines of different origin and form cytoplasmic speckle like structures that transiently interact with mitochondria under oxidative stress conditions. The ectopic expression of TRIM32 sensitizes cell death induced by oxidative stress whereas TRIM32 knockdown shows a protective effect. The turnover of TRIM32 is enhanced during oxidative stress and its expression induces ROS generation, loss of mitochondrial transmembrane potential and decrease in complex-I activity. The pro-apoptotic effect was rescued by pan-caspase inhibitor or antioxidant treatment. E3 ligase activity of TRIM32 is essential for oxidative stress induced apoptotic cell death. Furthermore, TRIM32 decreases X-linked inhibitor of apoptosis (XIAP) level and overexpression of XIAP rescued cells from TRIM32 mediated oxidative stress and cell death. Overall, the results of this study provide the first evidence supporting the role of TRIM32 in regulating oxidative stress induced cell death, which has implications in numerous pathological conditions including cancer and neurodegeneration

Assessment of utilization of child health services (under RCH program) and incorrect practices related to perinatal events in Jamnagar district, Gujarat, India

Background: India contributes to 25% of the over 6.9 million under-five deaths occurring worldwide every year with nearly half of them in neonatal period .This study is related indirectly with the causes of U5MR (e.g. Neonatal sepsis, prematurity-LBW) through focusing on service utilization related to perinatal events & incorrect practices of essential Newborn care (e.g. initiation of breast feeding and exclusive breastfeeding). Objectives: (1) Assess utilization of child health services related to perinatal events (2) Assess incorrect practices related to perinatal events (3) Assess effect of demographic variables on service utilization and association of these variables with practices.Methods: A cross-sectional study of 400 children (12 to 59 months) was done using multistage sampling technique in Jamnagar district. 120 children were selected from urban and 280 from rural areas as urban: rural ratio is 3:7 in India.Results: 93.55% children having umbilical infection. Birth weights were taken in majority of children (95.75%), 15.83% of those weighed were having low birth weight (LBW). Application on umbilical cord after birth was seen in 10.25% & prelacteal feed in about 1/3rd children. Breastfeeding immediately or within 4 hours after birth was seen in 3/4th, exclusive breastfeeding in 2/3rd children.Conclusions: Children having umbilical infection were treated indicating better utilization of curative services. Taking of birth weights in majority of children indicating good functioning of healthcare professionals but some of those weighed were having low birth weight (LBW) indicating underutilization of preventive-antenatal services indirectly affecting child health. Incorrect practices like application on umbilical cord after birth and prelacteal feed were seen in children. Recommended practices like breastfeeding immediately or within 4 hours after birth, exclusive breastfeeding were seen in children. Colostrum giving was more prevalent and low birth weight was less prevalent in rural areas compared to urban areas which indicated better health care utilization in rural areas.

Evaluation of changes in liver function test in first, second and third trimester of normal pregnancy

Background: Understanding of physiological adaptations of normal pregnancy remains a major goal of obstetrics, and without such knowledge, it is almost impossible to understand disease processes that can threaten women during pregnancy. Aim of this study is to evaluate changes in serum liver function tests in normal pregnant women in first, second and third trimester.Methods: A hospital based cross sectional in vitro study conducted at Civil Hospital, Ahmedabad (India). A study consists of 150 pregnant women and 50 matched control. Among the 150 pregnant women, 50 were in first trimester, 50 were in second trimester and 50 were in third trimester. Serum sample was taken and assessed for routine liver function tests.Results: Serum total and direct bilirubin concentrations were significantly lower in second and third trimester. Serum ALT and AST activity was slightly but significantly increased in third trimester. Serum ALP activity was significantly higher in second and third trimester. ALP activity increases as pregnancy advances. Serum GGT values were significantly lowers in third trimester. No significant change in serum total proteins concentration, but serum albumin concentration was significantly lower and serum globulin concentration was significantly higher in all three trimester. Serum albumin/globulin ratio was significantly reduced in second and third trimester.Conclusion: Such changes in in liver function tests during normal pregnancy can be misinterpreted as pathological and can also unmask or worsen preexisting disease. So the identification and understanding of these physiological changes in pregnancy is important for the diagnosis of liver diseases during pregnancy

Oblikovanje i vrednovanje plutajućih uljnih mikrozrnaca loratadina s produljenim zadržavanjem u želucu

Gastro retentive controlled release system of loratadine was formulated to increase the residence time in stomach and to modulate the release behaviour of the drug. Oil entrapped floating microbeads prepared by emulsion gelation method were optimized by 23 factorial design and a polymer ratio of 2.5:1.5 (pectin: sodium alginate) by mass, 15% (m/v) of oil (mineral oil or castor oil) and 0.45 mol L-1 calcium chloride solution were selected as the optimized processing conditions for the desired buoyancy and physical stability. In vitro drug release in fed state conditions demonstrated sustained release of loratadine for 8 h that best fitted the Peppas model with n < 0.45. The ethylcellulose coating on microbeads optimized by 22 factorial design resulted in controlled release formulation of loratadine that provided zero-order release for 8 h.U radu je opisana priprava plutajućih mikrozrnaca za kontrolirano oslobađanje loratadina metodom želiranja emulzije. Mikrozrnca sadrže ulja, a njihovo zadržavanje u želucu je produljeno. Priprava mikrozrnaca je optimirana 23 faktorijalnim dizajnom. Pripravci optimalne sposobnosti plutanja i stabilnosti dobiveni su uz omjer masa pektina i natrijevog alginata 2,5:1,5, udio mineralnog ulja ili ulja kastora 15% (m/v) i koncentraciju kalcijevog klorida 0,45 mol L1. Iz tih se mikrozrnaca loratadin oslobađa in vitro tijekom 8 h, a oslobađanje slijedi Peppasov model ako je n < 0,45. Mikrozrnca presvučena etilcelulozom optimirana 22 faktorijalnim dizajnom slijede kinetiku nultog reda tijekom 8 h

Feeding habits of milk shark, Rhizoprionodon acutus (Ruppell, 1837) in the Gujarat coastal waters of north-eastern Arabian Sea

The feeding habit of milk shark Rhizoprionodon acutus was investigated in 684 specimens collected along Gujarat coast (India) of north-eastern Arabian Sea from January 2013 to December 2014. The length range of females was 32–89.6 cm and males 33.5–89 cm. The shark foraged on diversified prey items which were pooled into four distinct groups i.e., teleosts, crustaceans, mollusks and annelids. Teleosts (Dietary coefficient, %QI = 83.05 and index of relative importance, %IRI = 78.40) were found to be the preferred food items followed by crustaceans (%QI = 16.21; %IRI = 19.78), which formed the secondary food item group. Mollusks (%QI = 0.74; %IRI = 1.69) and annelids (%QI = 0.01; %IRI = 0.14) constituted the accidental or accessory food items. The species, though is a pelagic predator, probably performs vertical movements in search of prey items. The shark also showed some sorts of preference and selectivity for clupeids, engraulids and carangids. Females though showed significantly lower index of relative fullness (IRF) (P ≤ 0.5) and comparatively lower vacuity index and lower mean number of preys per stomach compared to the males, the preference for prey items was not found to be significantly different between the females and males. Juveniles were found to have significantly higher IRF (P ≤ 0.5) and comparatively higher vacuity index than that of the adults, whereas the mean preys per stomach was found to be lower than that of the adults. Moreover, the prey preference was also significantly different between the juveniles and adults. The study provides necessary baseline information about the feeding habits of the shark in the region which will be helpful in understanding the trophodynamics of the species under the influence of overfishing and climate change