Co-producing policy relevant research

Co-produced research between policy and academia is of increasing importance, both to ensure meaningful impact and to bridge the perceived gap between academic and policy contexts. Embedding researchers within organisations has been one way to address these challenges as well as develop shared agendas and overcome barriers to using research in policy and practice. This chapter provides an example of developing co-produced research through the use of embedded researchers within a large, multi-disciplinary programme. It offers insight into the motivations and expectations of policy and academic partners' involvement and describes some of the practicalities of establishing and managing these roles. A selection of top tips are included for those who are interested in taking this approach to co-produced research

A cybernetic participatory approach for policy system of systems mapping: Case study of Inclusive Economies

Traditional participatory systems modelling demands synchronous time from many experts and face-to-face interaction. This is not always feasible (e.g., during a pandemic) and can restrict which participants can be included. There are additional limitations in the effectiveness of physical paper-based modelling when handling large complex systems with numerous variables and links between them. The key challenge facing practitioners is then how can we retain the benefits of traditional participatory modelling whilst exploiting the advantages of new technologies? This paper contributes to development of an original systematic methodology inspired by Cybernetic principles. The proposed method, referred to as 5X – standing for Expose, Explore, Exploit, Explain, and Expand – offers a fully virtual co-produced environment for iterative cycle of stakeholder engagement and feedback before, during and after workshops, leading to developing more confidence in systems mapping, and promoting knowledge across policy areas. A primary application of the proposed method in a real policy setting illustrates its capability to generate a shared policy understanding of a complex inclusive economy system, where there is conflicting or dispersed knowledge about system structure, refine this understanding through online feedback channels and dynamic visualisations, and transfer this understanding to wider policy and academic partners

Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity

We examined thrombospondin-1 (THBS1, alias TSP-1) expression in human synovial tissue (ST) during the resolution phase of chronic inflammation and elucidated its transcriptional regulation by the orphan receptor 4A2 (NR4A2). In vivo, rheumatoid arthritis (RA) serum and ST revealed altered expression levels and tissue distribution of TSP-1. After anti-tumor necrosis factor therapy, a reciprocal relationship between TSP-1 and NR4A2 expression levels was measured in patients with clinical and ST responses to biological treatment. In vitro, primary RA fibroblast-like synoviocytes (FLSs) expressed minimal TSP-1 mRNA levels with high transcript levels of NR4A2, vascular endothelial growth factor (VEGF), and IL-8 measured. Hypoxic modulation of RA FLSs resulted in inverse expression levels of TSP-1 compared with NR4A2, IL-8, and VEGF. Ectopic NR4A2 expression led to reduced TSP-1 mRNA and protein levels with concomitant increases in proangiogenic mediators. NR4A2 transcriptional activity, independent of DNA binding, repressed the hTSP-1 promoter leading to reduced mRNA and protein release in immortalized K4IM FLSs. Bioinformatic and deletion studies identified a 5' region of the TSP-1 promoter repressed by NR4A2 and proangiogenic transcription factors, including NF-κB and Ets1/2. Stable depletion of NR4A2 levels resulted in a shift in the TSP-1/VEGF expression ratio. Thus, modulation of TSP-1 expression is achieved through anti-tumor necrosis factor therapy effects on specific transcriptional networks, suggesting that enhanced TSP-1 expression may help restore tissue homeostasis during resolution of inflammatio

Redox-Mediated Angiogenesis in the Hypoxic Joint of Inflammatory Arthritis

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CRAFT Perception and Practice : A Canadian Discourse

This collection of writings represents the diversity of current craft theory and practice in Canada. The texts describe the different materials, methods, and concepts integrated by the crafts and their practitioners, as well as the aesthetics and the various social, perceptual and spiritual dimensions of the work. Issues are explored from a variety of perspectives, including feminist, linguistic and conceptual approaches. Biographical notes. 58 bibl. ref. Index 4 p