"Europeanization of the core executive in the transition from circumstances of EU accession to full EU membership"

Only recently have the direct and indirect ‘European’ impacts (of political outcomes at the European level) on domestic political systems started to be studied (i.e. Spanou, 1998; Bulmer and Burch, 1998 and 2001; Kassim, Peters and Wright, eds. 2000; Goetz and Hix, eds. 2001; Knill, 2001; Schneider and Aspinwall, eds. 2001; Goetz, ed., 2001; Laffan, 2001b). For the purpose of our paper, we understand Europeanization processes as the impacts of EU integration on specific countries' political institution-building and institutional adjustments including constitutional and administrative law, as well as on how the political system is organized and operated. This paper focuses on one of the three alternative perspectives of the ‘top-down’ approach to studying the processes of Europeanization as defined by Goetz (2001), namely the linkage perspective. Obviously, for recent new EU member states it is the national administrative adjustments for negotiating accession with the EU that have so far prevailed over national administrative adjustments made in the circumstances of (very recent) full EU membership. Our comparative research of three EU accession states/recent new EU member states, in line with a dynamic view, include Estonia, Hungary and Slovenia. While taking some key common features of the selected countries into account, the countries’ idiosyncrasies including variations in the institutional adaptation of their core executives relying on research findings in the framework of the European project ‘Organizing for Enlargement’ are investigated. Preliminary comparative research findings and tentative conclusions on variables that may cause variations in the adaptation of national administrations to the European integration challenges in the three (otherwise in some respects) relatively similar countries are presented

Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Fiering et al., 2015) that described how we intended to replicate selected experiments from the paper ‘Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis’ (Goetz et al., 2011). Here we report the results. Primary mouse embryonic fibroblasts (pMEFs) expressing caveolin 1 (Cav1WT) demonstrated increased extracellular matrix remodeling in vitro compared to Cav1 deficient (Cav1KO) pMEFs, similar to the original study (Goetz et al., 2011). In vivo, we found higher levels of intratumoral stroma remodeling, determined by fibronectin fiber orientation, in tumors from cancer cells co-injected with Cav1WT pMEFs compared to cancer cells only or cancer cells plus Cav1KO pMEFs, which were in the same direction as the original study (Supplemental Figure S7C; Goetz et al., 2011), but not statistically significant. Primary tumor growth was similar between conditions, like the original study (Supplemental Figure S7Ca; Goetz et al., 2011). We found metastatic burden was similar between Cav1WT and Cav1KO pMEFs, while the original study found increased metastases with Cav1WT (Figure 7C; Goetz et al., 2011); however, the duration of our in vivo experiments (45 days) were much shorter than in the study by Goetz et al. (2011) (75 days). This makes it difficult to interpret the difference between the studies as it is possible that the cells required more time to manifest the difference between treatments observed by Goetz et al. We also found a statistically significant negative correlation of intratumoral remodeling with metastatic burden, while the original study found a statistically significant positive correlation (Figure 7Cd; Goetz et al., 2011), but again there were differences between the studies in terms of the duration of the metastasis studies and the imaging approaches that could have impacted the outcomes. Finally, we report meta-analyses for each result

Ruth Goetz

Ruth Goetz, one of the most prolific writers for film in Germany in the period 1916-1927, with about sixty-five titles including original scripts and adaptations credited to her name, is not well known today. “The film writer is like a ‘violet’ that blooms hidden from sight,” she said at the beginning of her spectacular career during the late 1910s. “The audience does not know anything either about him or his work. Rarely does he get mentioned and he is never seen. If the film is bad, it’s the writer’s fault. If the film earns the label ‘good’ or ‘very good’ then the writer is entitled to a minuscule credit. This is different for the playwright and if one has started writing for the theater stage, one has quickly to adjust to this reality. I am letting this journal publish my photograph, so that people can at least once see a film writer” (600). Goetz was the only woman featured in this special 1918 issue of the Berlin-based trade magazine Kinematograph edited by E. A. Dupont and devoted to the invisible work of scenarists. A year earlier, one of her scripts had been included as a model for aspiring writers in one of the first manuals compiled by Wilhelm Adler. The film based on this script, Noemi, die blonde Jüdin/Noemi, the Blond Jewess (1917), was directed by Hubert Moest and served primarily as a star vehicle for actress Hedda Vernon

Nude or naked? : perceptions of the human form in art

This exhibit and catalog were produced by the Max Chambers Library, Archives & Special Collections. The exhibition featured art works created by Robert Francis Xavier Gerrer, Susan Goetz, Suzanne Thomas-Justice, Steve Goetzinger, George Oswalt, Doel Reed, Edith Goetz, Doug Hyde, Dee J. Lafon, John Seward, Andre Tutak, and Trent Lawson

Registered Report: Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replicating selected results from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012 were selected on the basis of citations and Altimetric scores (Errington et al., 2014). This Registered report describes the proposed replication plan of key experiments from ‘Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis’ by Goetz and colleagues, published in Cell in 2011 (Goetz et al., 2011). The key experiments being replicated are those reported in Figures 7C (a-d), Supplemental Figure S2A, and Supplemental Figure S7C (a-c) (Goetz et al., 2011). In these experiments, which are a subset of all the experiments reported in the original publication, Goetz and colleagues show in a subcutaneous xenograft model that stromal caveolin-1 remodels the intratumoral microenvironment, which is correlated with increased metastasis formation. The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange and the results of the replications will be published in eLife

Dr. Andrew Goetz

This interview with Dr. Andrew Goetz was conducted by the DUURJ Editor At Large

Refactoring Legacy JavaScript Code to Use Classes: The Good, The Bad and The Ugly

JavaScript systems are becoming increasingly complex and large. To tackle the challenges involved in implementing these systems, the language is evolving to include several constructions for programming- in-the-large. For example, although the language is prototype-based, the latest JavaScript standard, named ECMAScript 6 (ES6), provides native support for implementing classes. Even though most modern web browsers support ES6, only a very few applications use the class syntax. In this paper, we analyze the process of migrating structures that emulate classes in legacy JavaScript code to adopt the new syntax for classes introduced by ES6. We apply a set of migration rules on eight legacy JavaScript systems. In our study, we document: (a) cases that are straightforward to migrate (the good parts); (b) cases that require manual and ad-hoc migration (the bad parts); and (c) cases that cannot be migrated due to limitations and restrictions of ES6 (the ugly parts). Six out of eight systems (75%) contain instances of bad and/or ugly cases. We also collect the perceptions of JavaScript developers about migrating their code to use the new syntax for classes.Comment: Paper accepted at 16th International Conference on Software Reuse (ICSR), 2017; 16 page

Lothar Goetz - Black

Solo exhibition showing new works of Lothar Goetz Wall painting, drawings on paper, drawings on board - all dealing with the phenomenon of the " colour " blac