A Mixed-Integer Linear Programming Model for Transportation Planning in the Full Truck Load Strategy to Supply Products with Unbalanced Demand in the Just in Time Context: A Case Study

[EN] Growing awareness in cutting transport costs and minimizing the environmental impact means that companies are increasingly interested in using the full truck load strategy in their supply tasks. This strategy consists of filling trucks completely with one product type or a mixture of products from the same supplier. This paper aims to propose a mixed-integer linear programming model and procedure to fill trucks which considers limitations of stocks, stock levels and unbalanced demand and minimization of the total number of trucks used in the full truck load strategy. The results obtained from a case study are presented and are exported in a conventional spreadsheet available for a company in the automotive industry.Maheut ., JP.; García Sabater, JP. (2013). A Mixed-Integer Linear Programming Model for Transportation Planning in the Full Truck Load Strategy to Supply Products with Unbalanced Demand in the Just in Time Context: A Case Study. IFIP Advances in Information and Communication Technology. 397:576-583. doi:10.1007/978-3-642-40361-3_73S576583397Bitran, G.R., Haas, E.A., Hax, A.C.: Hierarchical production planning: a single stage system. Operations Research 29, 717–743 (1981)Sun, H., Ding, F.Y.: Extended data envelopment models and a practical tool to analyse product complexity related to product variety for an automobile assembly plant. International Journal of Logistics Systems and Management 6, 99–112 (2010)Boysen, N., Fliedner, M.: Cross dock scheduling: Classification, literature review and research agenda. Omega 38, 413–422 (2010)Garcia-Sabater, J.P., Maheut, J., Garcia-Sabater, J.J.: A two-stage sequential planning scheme for integrated operations planning and scheduling system using MILP: the case of an engine assembler. Flexible Services and Manufacturing Journal 24, 171–209 (2012)Ben-Khedher, N., Yano, C.A.: The Multi-Item Replenishment Problem with Transportation and Container Effects. Transportation Science 28, 37–54 (1994)Cousins, P.D.: Supply base rationalisation: myth or reality? European Journal of Purchasing Supply Management 5, 143–155 (1999)Kiesmüller, G.P.: A multi-item periodic replenishment policy with full truckloads. International Journal of Production Economics 118, 275–281 (2009)Goetschalckx, M.: Transportation Systems Supply Chain Engineering, vol. 161, pp. 127–154. Springer, US (2011)Liu, R., Jiang, Z., Fung, R.Y.K., Chen, F., Liu, X.: Two-phase heuristic algorithms for full truckloads multi-depot capacitated vehicle routing problem in carrier collaboration. Computers Operations Research 37, 950–959 (2010)Arunapuram, S., Mathur, K., Solow, D.: Vehicle Routing and Scheduling with Full Truckloads. Transportation Science 37, 170–182 (2003

Prediction model to estimate presence of coronary artery disease: retrospective pooled analysis of existing cohorts

Objectives To develop prediction models that better estimate the pretest probability of coronary artery disease in low prevalence populations

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children