25 research outputs found
Artritis reumatoide y riesgo cardiovascular
Cardiovascular disease (CVD) is the most frequent cause of premature death according to data
from the American Heart Association and World Health Organization. Incidence and prevalence are
on the rise. Rheumatoid Arthritis (RA) is the most common autoimmune disease. It is a chronic and
systemic disease characterized by articular involvement with deformity ranging from persistent
pain to premature disability. CVD is the most frequent cause of death in RA patients, even more
than in diabetes mellitus 2 or chronic kidney disease. Multiple CVD risk scales have been tested in
order to obtain a more accurate prediction of premature death by stroke or myocardial infarction
in RA patients. Most of the scales, even those adjusted including RA features like inflammation
and antibodies titles, have failed to properly predict the real CVD risk. Individually, RA specific
autoantibodies have been related with increased CVD risk and multiple mechanistic explanations
have arisen, generating even a new concept called âAutoimmune Atheromatosisâ. Nevertheless,
this association fails to give a full understanding of the accelerated and aggressive atheromatosis
process that RA patients develop. New studies oriented to mechanistic explanations are
necessary in order to develop new diagnostic targets and prevention strategies
Additional file 1: of LPS regulates the expression of glucocorticoid receptor α and ÎČ isoforms and induces a selective glucocorticoid resistance in vitro
LPS regulates the expression of GRα and GRÎČ isoforms in a epithelial cell line. HeLa cells were cultured with LPS for 24 h. The expression of GRα and GRÎČ was determined by Western blot. The median values of three different experiments, plotted as values relative to control are shown. * p < 0.05 and ** p < 0.01. (TIFF 128 kb
Variables associated with mortality in 103 patients with anti-neutrophil cytoplasmic antibodies associated vasculitis
Cumulative survival in patients with anti-neutrophil cytoplasmic
antibodies (ANCA) associated vasculitis (VAA) is 88 and 78% at 1 and 5
years, respectively. Despite this, mortality continues to be 2.7 times higher than
the general population. Differences in the clinical profile of VAA in different
ethnicities have been observed. Aim: To identify factors at the time of diagnosis,
associated with mortality at one year of follow-up and to describe the clinical
characteristics of these patients. Material and Methods: We identified in local
databases and reviewed clinical records of patients with VAA with at least one
year of follow up in a clinical hospital. Demographic and laboratory parameters
and clinical activity scores were analyzed. Results: Of 103 patients with VAA
identified, 65 met the inclusion criteria and were analyzed. Their age ranged
from 45 to 63 years and 56% were women. Thirty-five patients (54%) were
diagnosed as granulomatosis with Polyangiitis (GPA) and 30 patients (46%)
with Microscopic Polyangiitis (MPA). The frequency of renal disease was 53%
and pulmonary involvement occurred in 72%. At one year of follow-up 11
patients died resulting in a mortality of 17%. Seven patients died within three
months after diagnosis. MPO ANCA were more common than PR3 ANCA. In
the multivariate analysis, the presence of ophthalmological involvement, lung
kidney syndrome and a Five Factor Score (FFS) of 1 or more were independent
factors associated with mortality at one year. Conclusions: In these patients,
pulmonary manifestations predominate. Lung kidney syndrome, ophthalmological
involvement and a FFS score â„ 1 were associated with mortality