A study of wing body blending for an advanced supersonic transport

Increases in supersonic cruise lift drag ratio were sought at Mach numbers 2.2 and 2.7 using wing body planform and thickness blending. Constrained twist and camber optimization was performed in the presence of nacelles. Wing and fuselage thickness distributions were optimized for either minimum volume wave drag or minimum total pressure wave drag. The zero leading edge suction lift drag ratios were determined for three wing planforms. The magnitude of the effect of leading edge suction on attainable lift drag ratio was defined on one planform and estimation of available leading edge suction was made

Study of hypersonic propulsion/airframe integration technology

An assessment is done of current and potential ground facilities, and analysis and flight test techniques for establishing a hypersonic propulsion/airframe integration technology base. A mach 6 cruise prototype aircraft incorporating integrated Scramjet engines was considered the baseline configuration, and the assessment focused on the aerodynamic and configuration aspects of the integration technology. The study describes the key technology milestones that must be met to permit a decision on development of a prototype vehicle, and defines risk levels for these milestones. Capabilities and limitations of analysis techniques, current and potential ground test facilities, and flight test techniques are described in terms of the milestones and risk levels

MAGIC observations of Mkn 421 in 2008, and related optical/X-ray/TeV MWL study

The HBL-type blazar Markarian 421 is one of the brightest TeV gamma-ray sources of the Northern sky. From December 2007 until June 2008 it was intensively observed in the VHE (E>100 GeV) band by the MAGIC gamma-ray telescope. The source showed intense and prolonged activity during the whole period. In some nights the integral flux rose up to 3.6 Crab units (E>200 GeV). Intra-night rapid flux variations were observed. We compared the optical (KVA) and X-ray (RXTE-ASM, Swift-XRT) data with the MAGIC VHE data, investigating the correlations between different energy bands.Comment: 4 pages,4figures, Contribution to the 31st ICRC, Lodz, Poland, July 200

Stress-drop heterogeneity within tectonically complex regions: a case study of San Gorgonio Pass, southern California

In general, seismic slip along faults reduces the average shear stress within earthquake source regions, but stress drops of specific earthquakes are observed to vary widely in size. To advance our understanding of variations in stress drop, we analysed source parameters of small-magnitude events in the greater San Gorgonio area, southern California. In San Gorgonio, the regional tectonics are controlled by a restraining bend of the San Andreas fault system, which results in distributed crustal deformation, and heterogeneous slip along numerous strike-slip and thrust faults. Stress drops were estimated by fitting a Brune-type spectral model to source spectra obtained by iteratively stacking the observed amplitude spectra. The estimates have large scatter among individual events but the median of event populations shows systematic, statistically significant variations. We identified several crustal and faulting parameters that may contribute to local variations in stress drop including the style of faulting, changes in average tectonic slip rates, mineralogical composition of the host rocks, as well as the hypocentral depths of seismic events. We observed anomalously high stress drops (>20 MPa) in a small region between the traces of the San Gorgonio and Mission Creek segments of the San Andreas fault. Furthermore, the estimated stress drops are higher below depths of ∼10 km and along the San Gorgonio fault segment, but are lower both to the north and south away from San Gorgonio Pass, showing an approximate negative correlation with geologic slip rates. Documenting controlling parameters of stress-drop heterogeneity is important to advance regional hazard assessment and our understanding of earthquake rupture processes

A double parton scattering background to Higgs boson production at the LHC

The experimental capability of recognizing the presence of b quarks in complex hadronic final states has addressed the attention towards final states with b\bar{b} pairs for observing the production of the Higgs boson at the LHC, in the intermediate Higgs mass range.We point out that double parton scattering processes are going to represent a sizeable background to the process.Comment: 9 pages, 2 figure

A ‘modified de Gramont’ regimen of fluorouracil, alone and with oxaliplatin, for advanced colorectal cancer

The standard de Gramont (dG) regimen of fortnightly leucovorin, bolus fluorouracil and 22-h infusion of fluorouracil, d1+2, and the same regimen plus oxaliplatin, are effective but also cumbersome. We therefore present simplified ‘Modified de Gramont’ (MdG) regimens. Forty-six advanced gastrointestinal cancer patients entered a dose-exploring study of MdG, including an expanded cohort of colorectal cancer patients at optimum dose. Treatment (fortnightly) comprised: 2-h i.v.i. leucovorin (350 mg d,l-LV or 175 mg l-LV, not adjusted for patient surface area); bolus fluorouracil (400 mg m−2), then ambulatory 46-h fluorouracil infusion (2000–3600 mg m−2, cohort escalation). Subsequently, 62 colorectal patients (25 unpretreated; 37 fluorouracil-resistant) received MdG plus oxaliplatin (OxMdG) 85 mg m−2. Fluorouracil pharmacokinetics during MdG were compared with dG. The optimum fluorouracil doses for MdG alone were determined as 400 mg m−2 bolus + 2800 mg m−2 46-h infusion. A lower dose of 400 mg m−2 bolus + 2400 mg m−2 infusion which, like dG produces minimal toxicity, was chosen for the OxMdG combination. Fluorouracil exposure (AUC0–48 h) at this lower dose is equivalent to dG. With OxMdG, grade 3–4 toxicity was rare (neutropenia 2.8% cycles; vomiting or diarrhoea <1% cycles), but despite this there were two infection-associated deaths. Oxaliplatin was omitted for cumulative neurotoxicity in 17 out of 62 patients. Objective responses in colorectal cancer patients were: 1st-line MdG (22 assessable): PR=36%, NC=32%, PD=32%. 1st-line OxMdG (24 assessable): CR/PR=72%; NC=20%; PD=8%; 2nd line OxMdG (34 assessable): PR=12%; NC=38%; PD=50%. MdG and OxMdG are convenient and well-tolerated. OxMdG was particularly active as 1st-line treatment of advanced colorectal cancer. Both regimens are being further evaluated in the current UK MRC phase III trial

Data mining with neural networks and support vector machines using the R/rminer tool

We present rminer, our open source library for the R tool that facilitates the use of data mining (DM) algorithms, such as neural Networks (NNs) and support vector machines (SVMs), in classification and regression tasks. Tutorial examples with real-world problems (i.e. satellite image analysis and prediction of car prices) were used to demonstrate the rminer capabilities and NN/SVM advantages. Additional experiments were also held to test the rminer predictive capabilities, revealing competitive performances.Fundação para a Ciência e a Tecnologia (FCT) - PTDC/EIA/64541/200

Wastewater disposal and earthquake swarm activity at the southern end of the Central Valley, California

Fracture and fault zones can channel fluid flow and transmit injection-induced pore pressure changes over large distances (>km), at which seismicity is rarely suspected to be human induced. We use seismicity analysis and hydrogeological models to examine the role of seismically active faults in inducing earthquakes. We analyze a potentially injection-induced earthquake swarm with three events above M4 near the White Wolf fault (WWF). The swarm deviates from classic main aftershock behavior, exhibiting uncharacteristically low Gutenberg-Richter b of 0.6, and systematic migration patterns. Some smaller events occurred southeast of the WWF in an area of several disposal wells, one of which became active just 5 months before the main swarm activity. Hydrogeological modeling revealed that wastewater disposal likely contributed to seismicity via localized pressure increase along a seismically active fault. Our results suggest that induced seismicity may remain undetected in California without detailed analysis of local geologic setting, seismicity, and fluid diffusion