Réhabilitation de sites miniers, exemple du Grand'Baume.

Présente d'abord l'étude générale de réhabilitation qui comprend une étude paysagère. Décrit ensuite les travaux et techniques de reverdissement : engazonnement et plantations

Between-Tactor Display Using Dynamic Tactile Stimuli

Display of illusory vibration locations between physical vibrotactile motors (tactors) placed on the skin has the potential to reduce the number of tactors in distributed tactile displays. This paper presents a between-tactor display method that uses dynamic tactile stimuli to generate illusory vibration locations. A belt with only 6 vibration motors displays 24 targets consisting of on-tactor and between-tactor locations. On-tactor locations are represented by simply vibrating the relevant single tactor. Between-tactor locations are displayed by adjusting the relative vibration amplitudes of two adjacent motors, with either (1) constant vibration amplitudes or (2) perturbed vibration amplitudes (creating local illusory motion). User testing showed that perturbations improve recognition accuracy for in-between tactor localization

MODELOS SINTÉTICOS DE APRENDIZAGEM PARA APLICAÇÃO DE INJEÇÃO PELAS VIAS INTRAMUSCULAR E SUBCUTÂNEA EM CÃES

Na Medicina Veterinária, a aplicação de injeções é uma das habilidades clínicas que pode causar ansiedade nos estudantes, interferindo na aprendizagem. O objetivo do presente estudo foi desenvolver e validar modelos sintéticos de aprendizagem para aplicação de injeção pelas vias intramuscular e subcutânea em cães. A metodologia incluiu a confecção de três modelos sintéticos, sendo um para administração de injeção intramuscular no membro pélvico, outro para injeção intramuscular nos músculos lombodorsais e um terceiro para injeção subcutânea. Foram utilizadas borrachas de silicone de diferentes densidades para a obtenção das consistências desejadas. Os modelos foram acoplados em manequins de pelúcia e passaram por avaliação de médicos veterinários experientes. Após ajustes sugeridos, os modelos foram utilizados em aula por 69 estudantes da disciplina de Semiologia Geral Veterinária. No final da aula, os estudantes responderam a um questionário, para opinar sobre o aprendizado com os modelos, que contava com questões em escala Likert de 5 pontos e questões abertas. A maioria dos estudantes (98,4%) concordou ou concordou fortemente quanto à contribuição dos métodos utilizados para seu aprendizado e 92,6% disseram se sentir mais confiantes para aplicação de injeção no animal vivo. Após aula com o modelo sintético, 20 estudantes tiveram a oportunidade de aplicar injeções pela via subcutânea em cães vivos, sendo que 100% dos estudantes concordaram ou concordaram fortemente que o modelo sintético auxiliou na realização da técnica de injeção no animal vivo. Os modelos se mostraram uma ferramenta eficiente para o aprendizado de aplicação de injeção pelas vias intramuscular e subcutânea em cães

Age-related biological differences in children's and adolescents' very rare tumors

Very rare tumors (VRTs) in pediatric age represent many different diseases. They present an annual incidence < 2/1000,000 and correspond to about 11% of all cancers in patients aged 0–14 years. They can be roughly divided into two groups: one including tumors that are also rare in adults, and the other group includes adult-type tumors rarely encountered in children and adolescents. Although there is an obvious gap in knowledge regarding oncogenesis in pediatric cancers, there is some evidence of the involvement of various signalling pathways in the development of tumors in children and adolescents and sometimes in young adults. In addition, despite the rarity of these neoplasms, several attempts have been made to disclose the underlying mechanisms. More effort and resources have urgently to be devoted to deepening current knowledge and integrating new findings into the therapeutic approach, which nowadays relies on the treatment modalities used in adult oncology. The aim of this paper is to provide a review of the main solid VRTs occurring in both the pediatric and the adult age groups, highlighting the variability between groups in their biological and clinical course

Adrenocortical tumours in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations

Adrenocortical tumours (ACTs) are rare during childhood. A complete surgical resection provides the best chance of cure, but the role and efficacy of the adjuvant therapy are still controversial. Various histologic criteria of malignancy for ACTs adopted in children do not facilitate comparative studies and are not completely shared. Therefore, a sharp demarcation between benign and malignant lesions has not been recognised, making it difficult to identify who potentially needs perioperative therapy. This manuscript presents the internationally harmonised recommendations for the diagnosis and treatment of ACTs in children and adolescents, established by the European Cooperative Study Group for Paediatric Rare Tumours (EXPeRT) group within the EU-funded project PARTNER (Paediatric Rare Tumours Network - European Registry)

ASO visual abstract: the value of the sentinel node procedure in pediatric extremity Rhabdomyosarcoma: a systematic review and retrospective cohort study

Development and application of statistical models for medical scientific researc

The role of cancer predisposition syndrome in children and adolescents with very rare tumours

Germline predisposing pathogenic variants (GPVs) are present in approximately 8 to 10% of children with all cancer types. Very rare tumours (VRTs) represent many different diseases, defined with an annual incidence < 2 / 1,000,000, and correspond to 11% of all cancers in patients aged 0-14 years. Some of these VRTs, including cancer typical for adults, develop in children with a cancer predisposition syndrome (CPS). Classically, three situations lead to consider this association: Some patients develop a VRT for which histology itself strongly suggests a GPV related to a CPS; others are referred for germline genetic testing because of a family or personal history and finally, a systematic molecular genomic tumour analysis, reveals a PV typical to a CPS. Depending on the samples tested and type of analysis performed, information can be directly available about the germline status of such a PV. Depicting the association between CPS and VRT is clinically important as some of these tumour types require adapted therapy, sometimes in the frontline setting, and the proposal of a specific surveillance programme to detect other malignancies. The diagnosis of CPS necessitates a careful familial evaluation and genetic counselling regarding the risks faced by the child or other family members. The aim of this paper is to propose a literature review of solid VRTs occurring in paediatric and young adult patients associated with CPSs

Value of the sentinel node procedure in pediatric extremity rhabdomyosarcoma: a systematic review and retrospective cohort study

Background Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the patient accordingly. An alternative to the current recommended lymph node sampling is the sentinel node procedure (SNP). Methods A systematic review was performed summarizing all published cases of SNP in addition to 13 cases from our hospital and 8 cases from two other hospitals that have not been published before. Results For all patients (n = 55), at least one SLN was identified, but the SNP technique used was not uniform. The SNP changed the nodal classification of eight patients (17.0%) and had a false-negative rate of 10.5%. Conclusions The SNP is recommendable for pediatric patients with extremity RMS. It can change lymph node status and can be used to sample patients in a more targeted way than nodal sampling alone. Therefore, we recommend use of the SNP in addition to clinical and radiological nodal assessment for pediatric patients with extremity RMS.Development and application of statistical models for medical scientific researc

Congenital mesoblastic nephroma 50 years after its recognition: A narrative review

Congenital mesoblastic nephroma (CMN) is a rare pediatric renal tumor with low malignant potential that most commonly occurs early in infancy. Treatment strategies are based on the few published CMN series, while a significant number of CMN patients have been described in case reports. The aim of this narrative review was to create an up‐to‐date overview of the literature. Complete surgical removal is curative in most cases. The risk of treatment‐related mortality (both surgery‐ and chemotherapy‐related) is relatively high in the first weeks of life, indicating that these young patients deserve special attention with respect to timing and type of treatment