Urbanism and architecture of reconstruction in Loiret (1940-1954)

Dès 1940, les hommes de l’art composent l’Urbanisme et l’Architecture du département. Le préfet lance des concours d’architecture auxquels de nombreux architectes participent. D’autres concours sont lancés par le MRU, et les architectes du département vont y participer avec succès. En parallèle, le préfet oblige les villes sinistrées à préparer un plan d’urbanisme. Avant même la loi qui va obliger d’autres communes à avoir un plan, Jean Royer compose ceux de Sully, Châteauneuf, Gien et Orléans. En parallèle, la participation active des sinistrés à la mise en place des projets témoigne de l’importance des questions dans le département. Les nombreux débats sont commentés par la presse locale avec enthousiasme.L’étude de la Reconstruction permet d’appréhender l’histoire de l’architecture et de l’urbanisme de la période d’une manière inédite, puisque le département est le témoin privilégié de la mise en œuvre par l’État d’une politique de reconstruction active.In 1940, men of art make up the Planning and Architecture in the Department. The prefect organizes architectural competitions which many architects participated. Other competitions are run by the MRU, and the architects of the department will participate successfully. In parallel, the warden forces the affected cities to prepare a development plan. Even before the law which will force other municipalities to have a plan, Jean Royer those composed of Sully, Chateauneuf, Gien and Orleans. In parallel, the active participation of victims in the creation of projects demonstrates the importance of issues within the department. Numerous debates are discussed by the local press with enthusiasm.The study of Reconstruction capture both the history of architecture and urbanism of the period in a manner unprecedented since the department is privileged to witness the implementation by the Government in politics of active reconstruction

Traitement d'urgence de l'inflammation pulpaire irréversible aiguë

NANCY1-SCD Pharmacie-Odontologie (543952101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Spine immobilization and neurological outcome in vertebral osteomyelitis SPONDIMMO, a prospective multicentric cohort

International audienc

Intrinsic Defect in Keratinocyte Function Leads to Inflammation in Hidradenitis Suppurativa

International audienceHidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating, follicular disease of the skin. Despite a high prevalence in the general population, the physiopathology of HS remains poorly understood. The use of antibiotics and immunosuppressive agents for therapy suggests a deregulated immune response to microflora. Using cellular and gene expression analyses, we found an increased number of infiltrating CD4(+) T cells secreting IL-17 and IFN-γ in perilesional and lesional skin of patients with HS. By contrast, IL-22-secreting CD4(+) T cells are not enriched in HS lesions contrasting with increased number of those cells in the blood of patients with HS. We showed that keratinocytes isolated from hair follicles of patients with HS secreted significantly more IL-1β, IP-10, and chemokine (C-C motif) ligand 5 (RANTES) either constitutively or on pattern recognition receptor stimulations. In addition, they displayed a distinct pattern of antimicrobial peptide production. These findings point out a functional defect of keratinocytes in HS leading to a balance prone to inflammatory responses. This is likely to favor a permissive environment for bacterial infections and chronic inflammation characterizing clinical outcomes in patients with HS

2020 French recommendations on the management of septic arthritis in an adult native joint

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Management and outcome of native joint septic arthritis: a nationwide survey in French rheumatology departments, 2016–2017

International audienceObjectives: To describe current management and outcome of native joint septic arthritis (NJSA) in French rheumatology departments.Methods: For this retrospective, nationwide multicentric study, 127 French rheumatology departments were contacted to report up to 12 cases of NJSA that occurred between 1 January 2016 and 31 December 2017. Characteristics, diagnosis procedures, therapeutic management and outcome were recorded.Results: Overall, 362 patients were included (mean age 64.0±18.6 years, median Charlson comorbidity index 3.5 (0-14)). Knee was the most frequent site (n=160 (38.9%)), and Staphylococcus sp (n=185 (51.4%)), the most frequent pathogen. All patients received antibiotics for a mean duration of 46.8 (±22.0) days, including intravenous route for a mean of 17.2 (±15.4) days. Management was heterogeneous. Surgical procedure was performed in 171 (48.3%), joint immobilisation in 128 (43.8%). During follow-up, 91 (28.3%) patients have had serious complications and 28 (9.2%) of them died. Factors associated with 1-year mortality were age (OR 1.08, 95% CI 1.04 to 1.13; p<0.001), Charlson's index (OR 1.30, 95% CI 1.06 to 1.58; p=0.012), presence of bacteraemia (OR 4.02, 95% CI 1.35 to 11.99; p=0.008), antibiotic use in the previous 3 months (OR 3.32, 95% CI 1.11 to 9.87; p=0.029) and Staphylococcus aureus NJSA compared with Streptococcus sp. NJSA (OR 7.24, 95% CI 1.26 to 41.68, p=0.027). The complete recovery with no adverse joint outcome at 1 year was observed in n=125/278 patients (55.0%).Conclusion: Prognosis of NJSA remained severe with a high rate of morbimortality. Its management was very heterogeneous. This study highlights the importance of the new French recommendations, published after the completion of the study, in order to facilitate NJSA management