The Effectiveness of Surgeon Decision on Pain Syndrome of Pelvic Origin Treatment in Women Estimated with the Model of Decision Tree

The purpose of the work is to investigate the effectiveness of different methods of treatment women with pain syndrome originated from pelvis and lower part of abdomen on the basis of retrospective analysis of 1092 histories of diseases during 2013–2017 р.р., Results. It was established that the probability of complete health restoration was 0,83 after surgical treatment and 0,62 after drug treatment. In case of initial inefficiency of drug treatment the probability of restoration of health as a result of surgical intervention was 0,40. The EPT in surgically treated patients was less than EPT in patients with therapeutic treatment by 3,29 times at the moment of making decision on the method of treatment.Мета роботи полягає у порівнянні ефективності різних методів лікування жінок з больовим синдромом мискового походження на основі ретроспективного аналізу 1092 історій хвороб пацієнтів, яким лікування було надано в період 2013–2017 р.р. Результати дослідження. Встановлено, що імовірність повного відновлення здоров’я склала 0,83 після хірургічного і 0,62 після консервативного лікування. У випадку, коли первинне консервативне лікування не приводило до одужання, імовірність одужання після проведення хірургічного втручання дорівнювала 0,40. Ефективність періоду лікування, розрахована для пацієнтів з первинним хірургічним лікуванням, була менша в 3,29 разу у порівнянні з ефективністю, розрахованої для пацієнтів з первинним консервативним лікуванням.Проведены ретроспективные исследования эффективности принятия решений при диагностике и лечении пациентов хирургического профиля — женщин, страдаючих хроническим болевым синдромом. Результаты анализа историй болезни 1092 пациенток, которым была оказана врачебная помощь в период 2013–2017 г.г., проведенного на основе построения дерева решений, показали, что вероятность выздоровления при проведении хирургического вмешательства составила 0,83, в то время как при проведении медикаментозного лечения — 0,62. В случае неэффективности медикаментозного лечения вероятность выздоровления уменьшалась до 0,40. Определены ключевые моменты применения системы поддержки решений хирурга, позволяющие повысить эффективность лечения данной категории пациентов

Изменения функциональной активности лимфоцитов у киндлинговых крыс и эффекты пентоксифиллина

Under condition of acute experiments on male Wistar rats it was shown that under condition of kindling formation induced via repeated subthreshold corazol administration (30,0 mg/kg, i.p.) the decreasing of blastogenic response induced by bacterial lypopolysaccharide and phytogemagglutinin was shown. This effect was detectable after 10-th convulsant injection and intensified in the course of kindling (21 injections of picrotoxin). Pentoxiphyllin (25,0 and 50,0 mg/kg, i.p.) caused antiseizure effects and effectively prevented kindling-induced decreasing of blastogenic response in dose-depended manner.В условиях острых опытов на крысах-самцах линии Вистар показано, что при формировании киндлинга с помощью повторного применения первоначально подпороговой дозы коразола (30,0 мг/кг, внутрибрюшинно) происходит снижение выраженности бластной трансформации лимфоцитов, вызываемой с помощью бактериального липополисахарида и фитогемагглютинина. Данный эффект обнаруживается после 10 инъекций конвульсанта и его выраженность увеличивается при сформированном киндлинге (21 инъекция). Применение пентоксифиллина (25,0-50,0 мг/кг, в/бр) предотвращает развитие эпилептогенных эффектов коразола, уменьшает выраженность эффекта подавления бласттрансформации лимфоцитов

Влияние электрической стимуляции (эс) палеоцеребеллярной коры на пенициллин-вызванные очаги эпилептической активности в коре головного мозга киндлинговых крыс

Electrical stimulation (ES) (0,25 ms, 100 Hz, 150-250 mcА) of paleocerebellar cortex (pyramis and culmen) caused the suppression of epileptogenic foci, induced in frontal cortex via application of penicillin solution (16 000 IU/ml) to male Wistar rats in three weeks from the moment of last corazol kindled administration. Antiepileptic effects have been pronounced in form of suppression of amplitude and frequency of spikes as well as in the net shortening of life-span of foci. Lower and higher intensities of ES did not cause suppression of focal epileptogenesis.Электрическая стимуляция (ЭС) (0,25 мс, 100 Гц, 150-250 мкА) палеоцеребеллярной коры (пирамидная долька, верхушка), осуществляемая через три недели после последнего киндлингового введения коразола (30,0 мг/кг, в/бр) крысам-самцам линии Вистар, сопровождалась угнетением активности эпилептических очагов, созданных в лобних отделах коры головного мозга аппликацией раствора пенициллина (16 000 МЕ/мл). Противоэпилептическое действие выражалось в подавлении частоты и амплитуды разрядов в очагах, сокращении времени их существования. ЭС меньшей или более высокой интенсивности не вызывало эффекта подавления очаговой эпилептической активности

Causes and consequences of pathogenic processes in evolution: Implications from experimental epilepsy in animals

Contains fulltext : 62152.pdf (publisher's version ) (Closed access)Examples from experimental epilepsy in animals are used to illustrate the view that a crucial role of the transfer of mechanisms from compensatory into pathogenic (e.g. lethal ones in the course of a disease), is played by the power of pathologic stimuli. In the genesis of epilepsy it is suggested that a critical increase of endogenous factors may underlie the conversion of the absence form of epilepsy into a generalized self-supporting form. The ability to precipitate endogenous self-augmenting mechanisms of diseases may have increased in the course of evolution. The lethal result of a serious pathogenic process leads to the suggestion that organisms cope with the disease by dying. This prevents spreading of the putative infectious disease within the population. The mechanisms of disease aggravation could pay a role in the survival of the species and in further evolutionary progress. This may explain why certain species may have survived in evolution and supports the theory of synthetic evolution

Pentoxifylline potentiates antiepileptic activity of diazepam on the model of treatment-resistant focal epilepsy

Kindling-syndrome was modeled in male Wistar rats using repeated corazole administration (25-30 mg/kg intraperitoneally). The effects of pentoxifylline (25 and 100 mg/kg intraperitoneally) and diazepam (0.05 and 1 mg/kg intraperitoneally) were studied in 3 weeks after kindling development under conditions of acute observation on the model of penicillin-induced foci in cerebral cortex. An anticonvulsant effect of combined treatment with diazepam and pentoxifylline in the doses, ineffective if administered separately (0.05 and 25 mg/kg intraperitoneally), was demonstrated. © 2013 Springer Science+Business Media New York

Are there different mechanisms of synchronization in the course of spike-wave discharges (SDS) burst development in WAG/Rij rats?

Contains fulltext : 56895.pdf ( ) (Open Access)In WAG/Rij rats the pair linear correlation r was calculated for bipolar recordings in fronto-temporal, fronto-occipital and occipito-temporal zones of both hemispheres as well as in paleocerebellar cortex (culmen). It was shown that development of SWD bursts resulted in interhemispheric decreases of correlation between the right occipito-temporal cortical region on one side, and left fronto-temporal on the contralateral side. Towards the end of SWD, we found an increased interhemispheric correlation between left fronto-temporal and right fronto-occipital cortical zones, as well as, between both fronto-temporal zones. Paleocerebellum correlates at a weak to moderate level during different periods of SWD burst generation;6 p

Pentoxifylline potentiates antiepileptic activity of diazepam on the model of treatment-resistant focal epilepsy

Kindling-syndrome was modeled in male Wistar rats using repeated corazole administration (25-30 mg/kg intraperitoneally). The effects of pentoxifylline (25 and 100 mg/kg intraperitoneally) and diazepam (0.05 and 1 mg/kg intraperitoneally) were studied in 3 weeks after kindling development under conditions of acute observation on the model of penicillin-induced foci in cerebral cortex. An anticonvulsant effect of combined treatment with diazepam and pentoxifylline in the doses, ineffective if administered separately (0.05 and 25 mg/kg intraperitoneally), was demonstrated. © 2013 Springer Science+Business Media New York

Functional relationships between brain and cerebellar cortex during absence and clonic seizures

Item does not contain fulltextThe relationships between frontal, temporal, and occipital zones of cortex of both hemispheres and paleocerebellar cortex in Wistar and WAG/Rij rats were investigated with an application of multiple linear regression analyses. Taking into consideration the dependence of epileptiform manifestations on sleep-wakefulness cycle, passive wakefulness state was used for data collection. The process of transition from absence to clonic seizure activity, which was provoked through the administration of sodium benzilpenicillin salt in WAG/Rij rats, was characterized as follows: 1) a preservation of high levels of interaction between brain structures in alpha band; 2) a pronounced decrease of interaction in delta and high-frequency rhythm bands; 3) moderate reduction of interaction between brain structures in the theta range. The increase of the number of connections of cerebellar cortex was marked in the course of transition from absence to clonic seizure activity, which might be in favor for the involvement of the cerebellum in the control of excitability of the brain.14 p

Cytokines and absence epilepsy

Cytokines are involved in various types of childhood epilepsies, although its role in absence epilepsy is not investigated. In two experiments the role of two cytokines, IL-1? and TNF-?, were investigated in a genetic model of absence epilepsy, the WAG/Rij rat. In the first experiment it was investigated whether cytokines may influence the expression of spike-wave discharges. In the second experiment, the levels of both cytokines were measured in brain and plasma of WAG/Rij and non-epileptic controls (ACI) at 2, 4 and 6 months in order to establish whether these cytokines are involved in the pathogenesis of absence epilepsy. Six months old freely moving WAG/Rij rats were injected i.p. with IL-1? (2?g/kg in 2 ml), TNF-? (2?g/kg in 2 ml) or a bovine salt solution and the EEG was recorded for 72 hrs. The hourly numbers of spike-wave discharges (SWD's) were determined, next behavior and body temperature were periodically monitored (Exp I). Naïve WAG/Rij and ACI rats of various ages were killed with an overdose of barbiturates, the blood was collected and the brains were quickly removed. Levels of cytokines were determined with ELISA methods (Exp II). IL-1? induced a large increase in the number of SWD in the 2-5 hours after its administration, TNF-? enhanced SWD's 6-18 hours after its administration. Both cytokines enhanced passive behavior, while body temperature was elevated only after TNF-?. There were no large differences between the two strains at any of the age groups (Exp II), however a significant strain by age effects was found for TNF- ? serum concentration. More specifically, at an age of two months non-epileptic rats had more than their age matched controls. It can be concluded that TNF- ? might protect rats during a stage that the first SWD start to appear. Moreover, increased levels of both cytokines affect the expression of SWD in WAG/Rij rats albeit with a different time constant. This suggests that the results found after TNF-? are due to the new synthesis IL-1?. If this is the case than it seems that only IL-1? affects the expression of SWD