Renal responses to exercise in heart and kidney transplant patients

There is a lack of information about renal responses in heart and kidney transplant patients after intense physical exercise. Eleven heart and ten kidney trans plant recipients, as well as two control groups of healthy subjects, were given a maximum exercise test on a bicycle ergometer. One control group was also given a moderate load corresponding to the peak load of the kidney transplant group. Blood and urine samples were collected before and after exercise and assayed for lactate, creatinine, total protein, and albumin. The glomerular filtration rate remained stable at the end of exercise in the transplant patients, while there was a slight (17%) decrease in the control group. Albumin excretion rates after maximum exercise attained a mean of 237 μg min-1 in the control group and a mean of 45 and 16 μg min-1 respectively, in the heart and kidney groups. Postexercise proteinuria seemed to be related to the absolute intensity of the event, but kidney transplant patients showed a reduced effect as compared to heart transplant patients. We conclude that short-term, maximum exercise in heart and kidney transplant recipients is not detrimental to kidney function.SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe

Efficacité de l’ivabradine (Procoralan®) dans le traitement de l’angor stable au stade terminal (5D) de l’insuffisance rénale chronique

12e réunion commune de la Société de Néphrologie et de la Société Francophone de Dialyse (Bruxelles, 28/9 au 1/10/2010)info:eu-repo/semantics/publishe

La femme et la réadaptation cardiaque à l’hôpital Erasme

info:eu-repo/semantics/publishe

Amélioration de la capacité physique en réadaptation cardiaque: une question de sexe?

info:eu-repo/semantics/publishe

Mutations of the Quorum Sensing-Dependent Regulator VjbR Lead to Drastic Surface Modifications in Brucella melitensis▿

Successful establishment of infection by bacterial pathogens requires fine-tuning of virulence-related genes. Quorum sensing (QS) is a global regulation process based on the synthesis of, detection of, and response to small diffusible molecules, called N-acyl-homoserine lactones (AHL), in gram-negative bacteria. In numerous species, QS has been shown to regulate genes involved in the establishment of pathogenic interactions with the host. Brucella melitensis produces N-dodecanoyl homoserine lactones (C12-HSL), which down regulate the expression of flagellar genes and of the virB operon (encoding a type IV secretion system), both of which encode surface virulence factors. A QS-related regulator, called VjbR, was identified as a transcriptional activator of these genes. We hypothesized that VjbR mediates the C12-HSL effects described above. vjbR alleles mutated in the region coding for the AHL binding domain were constructed to test this hypothesis. These alleles expressed in trans in a ΔvjbR background behave as constitutive regulators both in vitro and in a cellular model of infection. Interestingly, the resulting B. melitensis strains, unable to respond to AHLs, aggregate spontaneously in liquid culture. Preliminary characterization of these strains showed altered expression of some outer membrane proteins and overproduction of a matrix-forming exopolysaccharide, suggesting for the first time that B. melitensis could form biofilms. Together, these results indicate that QS through VjbR is a major regulatory system of important cell surface structures of Brucella and as such plays a key role in host-pathogen interactions

GNAS defects identified by stimulatory G protein alpha subunit signalling studies in platelets.

Context. GNAS is an imprinted region that gives rise to several transcripts, antisense transcripts and noncoding RNAs, including transcription of RNA encoding the alpha subunit of the stimulatory G protein (Gsalpha). The complexity of the GNAS cluster results in ubiquitous genomic imprints, tissue-specific Gsalpha expression and multiple genotype-phenotype relationships. Phenotypes resulting from genetic and epigenetic abnormalities of the GNAS region include Albright's Hereditary Osteodystrophy (AHO), pseudohypoparathyroidism types Ia (PHPIa) and Ib (PHPIb), and pseudopseudohypoparathyroidism (PPHP). Objective. To study the complex GNAS pathology by a functional test, as an alternative to the generally used but labour-intensive erythrocyte complementation assay. Design and patients. We report the first platelet-based diagnostic test for Gsalpha hypofunction, supported by clinical, biochemical, and molecular data for 6 patients with PHPIa or PPHP and 9 patients with PHPIb. The platelet test is based on the inhibition of platelet aggregation by cAMP, produced after Gsalpha stimulation. Results. Platelets are easily accessible, and platelet aggregation responses were found to reflect Gsalpha signaling defects in patients, in concordance with the patient's phenotype and genotype. Gsalpha hypofunction in PHPIa and PPHP patients with GNAS mutations was clearly detected by this method. Mildly decreased or normal Gsalpha function was detected in patients with PHPIb with either an overall or exon1A-only epigenetic defect, respectively. Platelet Gsalpha expression was reduced in both PHPIb patient groups while XLalphas was upregulated only in PHPIb patients with the broad epigenetic defect. Conclusion. The platelet-based test is a novel tool for establishing the diagnosis of Gsalpha defects, which may be otherwise quite challenging

Transmission and Transgression

This volume aims at exploring the reinvention of philosophy, literature and science in the early modern era to show how writers and readers collectively engaged in redefining the transmission of knowledge, whether ancient or newly discovered. In its first section, the contributors deal with religious, ideological and philosophical issues; in the second, they tackle art and science, while, in the third, they provide new insights about travelling and the circulation of ideas. These ten chapters thus relate transmission to the fundamental role of transgression by considering English writers and their challenging ideas in the context of their engagement with a flowering print market. The importance of public discourse as well as of memory and tradition, along with the need for renewal and reform which redefined England’s identity, are therefore being explored here. As the book refines on previous generalisations on the interacting concepts of transmission and transgression in early modern England, it also addresses the following questions: is there such a thing as a specifically English transgressive aesthetics? Can it be seen as a philosophy? Eventually, does transgression necessarily deny its own sources?À travers les facettes de ses dix chapitres, ce volume offre des perspectives variées sur les notions croisées de transmission et de transgression au sein de l’Angleterre moderne. La première partie du livre est consacrée à la religion et à l’idéologie. Partant de La légende dorée (1260), Jean-Marie Maguin analyse au fil du temps les liens complexes qui relient l’arbre de la connaissance du jardin d’Eden à la croix du Christ. Margaret Jones-Davies s’intéresse de son côté au concept de « mal moderne » dans l’Angleterre du 16e siècle, tandis que Pierre Lurbe s’attache aux idées hétérodoxes aux idées du libre-penseur John Toland (1660-1722). La seconde partie s’ouvre sur un chapitre de Pierre Iselin sur l’importance de la musique à la Renaissance. Mickael Popelard explique ensuite que les savants étaient alors souvent perçus comme des personnages sulfureux. Enfin, avec le cas du poète James Thomson (1700-1748), Pierre Carboni se penche un siècle et demi plus tard sur ces mêmes rapports entre littérature et science. La troisième et dernière partie traite de la circulation des idées. William T. Rossiter y analyse les traductions du poète et diplomate Thomas Wyatt (1503-1542) qui ouvrent un espace de transgression à ses lecteurs, tandis qu’Anne Geoffroy présente un autre exemple de transmission transgressive à partir d’un texte de Robert Greene, The Royall Exchange (1590). Christophe Camard élargit cette problématique à propos des traductions des nouvelles italiennes de la Renaissance. Johann Gregory termine cette partie avec un portrait décapant de l’écrivain John Taylor (1578-1653), infatigable voyageur issu d’un milieu modeste