Non-Steroidal Anti-Inflammatory Drugs and Cognitive Function: Are Prostaglandins at the Heart of Cognitive Impairment in Dementia and Delirium ?

Studies of non-steroidal anti-inflammatory drugs (NSAIDs) in rheumatoid arthritis imply that inflammation is important in the development of Alzheimer’s disease (AD). However, these drugs have not alleviated the symptoms of AD in those who have already developed dementia. This suggests that the primary mediator targeted by these drugs, PGE2, is not actively suppressing memory function in AD. Amyloid-β oligomers appear to be important for the mild cognitive changes seen in AD transgenic mice, yet amyloid immunotherapy has also proven unsuccessful in clinical trials. Collectively, these findings indicate that NSAIDs may target a prodromal process in mice that has already passed in those diagnosed with AD, and that synaptic and neuronal loss are key determinants of cognitive dysfunction in AD. While the role of inflammation has not yet become clear, inflammatory processes definitely have a negative impact on cognitive function during episodes of delirium during dementia. Delirium is an acute and profound impairment of cognitive function frequently occurring in aged and demented patients exposed to systemic inflammatory insults, which is now recognised to contribute to long-term cognitive decline. Recent work in animal models is beginning to shed light on the interactions between systemic inflammation and CNS pathology in these acute exacerbations of dementia. This review will assess the role of prostaglandin synthesis in the memory impairments observed in dementia and delirium and will examine the relative contribution of amyloid, synaptic and neuronal loss. We will also discuss how understanding the role of inflammatory mediators in delirious episodes will have major implications for ameliorating the rate of decline in the demented population

Quran's view of family problems

Yüksek Lisans Tezi YÖK Merkezi No:350797Aile, toplumun temelidir. Aile, insanlık tarihinin en eski müessesesi olmakla beraber, her toplumda varlığını ve önemini korumuştur. İslam dininde evliliğin devamı esastır. Ailenin devamını sağlamak için her türlü çareye başvurulduğu halde bazen evliliğin sona ermesi, devamından daha hayırlı olabilir. Günümüzde modernleşme, sanayileşme, teknolojik gelişme, kentleşme ve yaşam felsefesindeki değişim süreçlerinin ortaya çıkardığı oluşumlar, başta insan ilişkileri olmak üzere toplumu ve aileyi derinden etkilemiştir. Bu nedenle biz de tezimizde bu konu üzerinde çalışmayı uygun gördük.Çalışmamız, girişten sonra iki bölümden oluşmaktadır. Giriş bölümünde, araştırmanın konusu, önemi ve yöntemi hakkında gerekli açıklamalar yapılmıştır. I. Bölüm?de, aile kavramı hakkında genel bilgi verilmiş olup, II. Bölüm?de ise, günümüzde meydana gelen aile problemleri üzerinde durulmuş ve bu problemlere, Kur?an ayetlerine dayanarak çözümler üretilmeye çalışılmıştır.Family is the foundation of the community. Being the oldest institution of the human history family has protected its existence and importance in every community. In Islamic religion, continuation of the family is essential. Although all kinds of remedies have been tried for the continuation of family, sometimes it can be better for the marriage to come to an end than to continue.Nowadays; modernization, industrialization, technological development, urbanization and the formations that are caused by the change processes in life philosophy have deeply affected especially human relations and also community and family. That is why we chose to work on this topic in our thesis.Our work consists of two parts after introduction. In the introduction part, there are required explanations about the subject, purpose, significance and method of the research. In the first part, there is general information about the family concept and in the second part, the family problems that occur today are being elaborated and solutions of these problems are being tried to be produced based on the Quran verse