Decreased Consumption of Added Fructose Reduces Waist Circumference and Blood Glucose Concentration in Patients With Overweight and Obesity. The DISFRUTE Study: A Randomised Trial in Primary Care

The relationship between fructose intake and insulin resistance remains controversial. Our purpose was to determine whether a reduction in dietary fructose is effective in decreasing insulin resistance (HOMA2-IR). This field trial was conducted on 438 adults with overweight and obese status, without diabetes. A total of 121 patients in a low fructose diet (LFD) group and 118 in a standard diet (SD) group completed the 24-week study. Both diets were prescribed with 30–40% of energy intake restriction. There were no between-group differences in HOMA2-IR. However, larger decreases were seen in the LFD group in waist circumference (−7.0 vs. −4.8 = −2.2 cms, 95% CI: −3.7, −0.7) and fasting blood glucose −0.25 vs. −0.11 = −0.14 mmol/L, 95% CI: −0.028, −0.02). The percentage of reduction in calorie intake was similar. Only were differences observed in the % energy intake for some nutrients: total fructose (−2 vs. −0.6 = −1.4, 95% CI: −2.6, −0.3), MUFA (−1.7 vs. −0.4 = −1.3, 95% CI: −2.4, −0.2), protein (5.1 vs. 3.6 = 1.4, 95% CI: 0.1, 2.7). The decrease in fructose consumption originated mainly from the reduction in added fructose (−2.8 vs. −1.9 = −0.9, 95% CI: −1.6, −0.03). These results were corroborated after multivariate adjustments. The low fructose diet did not reduce insulin resistance. However, it reduced waist circumference and fasting blood glucose concentration, which suggests a decrease in hepatic insulin resistance.Sin financiación5.719 JCR (2020) Q1, 17/88 Nutrition & Dietetics1.418 SJR (2020) Q1, 18/332 Food ScienceNo data IDR 2020UE

Search for vector-like quarks at ATLAS

Vector like quarks appear in many theories beyond the Standard Model as a way to cancel the mass divergence for the Higgs boson. The current status of the ATLAS searches for the production of vector-like quarks will be reviewed for proton-proton collisions at 13 TeV. This presentation will address the analysis techniques, in particular, the selection criteria, the background modelling and the related experimental uncertainties. The phenomenological implications of the obtained results will also be discussed