10,150 research outputs found
Application Experiences of NASTRAN Thermal Analysis in Engineering
The application of the thermal analysis phase of NASTRAN in engineering is described. Some illustrative samples are presented to demonstrate the applicability and limitation of NASTRAN thermal analysis capability. The results of the evaluation of the relative efficiency, applicability and accuracy among NASTRAN, other finite element programs, and finite difference programs are also presented
Implementation experiences of NASTRAN on CDC CYBER 74 SCOPE 3.4 operating system
The implementation of the NASTRAN system on the CDC CYBER 74 SCOPE 3.4 Operating System is described. The flexibility of the NASTRAN system made it possible to accomplish the change with no major problems. Various sizes of benchmark and test problems, ranging from two hours to less than one minute CP time were run on the CDC CYBER SCOPE 3.3, Univac EXEC-8, and CDC CYBER SCOPE 3.4. The NASTRAN installation deck is provided
Seismic analysis of nuclear power plant structures
Primary structures for nuclear power plants are designed to resist expected earthquakes of the site. Two intensities are referred to as Operating Basis Earthquake and Design Basis Earthquake. These structures are required to accommodate these seismic loadings without loss of their functional integrity. Thus, no plastic yield is allowed. The application of NASTRAN in analyzing some of these seismic induced structural dynamic problems is described. NASTRAN, with some modifications, can be used to analyze most structures that are subjected to seismic loads. A brief review of the formulation of seismic-induced structural dynamics is also presented. Two typical structural problems were selected to illustrate the application of the various methods of seismic structural analysis by the NASTRAN system
Energetics of mixing for the filling box and the emptying-filling box
The mixing efficiency of a plume in a filling box and an emptying-filling box
is calculated for both transient and steady states. The mixing efficiency of a
plume in a filling box in an asymptotic steady state is 1/2, independent of the
details of this state or how the plume is modelled. The mixing efficiency of a
plume in an emptying-filling box in steady state is 1 - xi, where xi = h/H, the
depth of the ambient layer h non-dimensionalised by the height of the box H. A
deeper mixed layer therefore corresponds to a higher mixing efficiency
Noisy Monte Carlo: Convergence of Markov chains with approximate transition kernels
Monte Carlo algorithms often aim to draw from a distribution by
simulating a Markov chain with transition kernel such that is
invariant under . However, there are many situations for which it is
impractical or impossible to draw from the transition kernel . For instance,
this is the case with massive datasets, where is it prohibitively expensive to
calculate the likelihood and is also the case for intractable likelihood models
arising from, for example, Gibbs random fields, such as those found in spatial
statistics and network analysis. A natural approach in these cases is to
replace by an approximation . Using theory from the stability of
Markov chains we explore a variety of situations where it is possible to
quantify how 'close' the chain given by the transition kernel is to
the chain given by . We apply these results to several examples from spatial
statistics and network analysis.Comment: This version: results extended to non-uniformly ergodic Markov chain
A family of thermostable fungal cellulases created by structure-guided recombination
SCHEMA structure-guided recombination of 3 fungal class II cellobiohydrolases (CBH II cellulases) has yielded a collection of highly thermostable CBH II chimeras. Twenty-three of 48 genes sampled from the 6,561 possible chimeric sequences were secreted by the Saccharomyces cerevisiae heterologous host in catalytically active form. Five of these chimeras have half-lives of thermal inactivation at 63°C that are greater than the most stable parent, CBH II enzyme from the thermophilic fungus Humicola insolens, which suggests that this chimera collection contains hundreds of highly stable cellulases. Twenty-five new sequences were designed based on mathematical modeling of the thermostabilities for the first set of chimeras. Ten of these sequences were expressed in active form; all 10 retained more activity than H. insolens CBH II after incubation at 63°C. The total of 15 validated thermostable CBH II enzymes have high sequence diversity, differing from their closest natural homologs at up to 63 amino acid positions. Selected purified thermostable chimeras hydrolyzed phosphoric acid swollen cellulose at temperatures 7 to 15°C higher than the parent enzymes. These chimeras also hydrolyzed as much or more cellulose than the parent CBH II enzymes in long-time cellulose hydrolysis assays and had pH/activity profiles as broad, or broader than, the parent enzymes. Generating this group of diverse, thermostable fungal CBH II chimeras is the first step in building an inventory of stable cellulases from which optimized enzyme mixtures for biomass conversion can be formulated
Delineation of the Native Basin in Continuum Models of Proteins
We propose two approaches for determining the native basins in off-lattice
models of proteins. The first of them is based on exploring the saddle points
on selected trajectories emerging from the native state. In the second
approach, the basin size can be determined by monitoring random distortions in
the shape of the protein around the native state. Both techniques yield the
similar results. As a byproduct, a simple method to determine the folding
temperature is obtained.Comment: REVTeX, 6 pages, 5 EPS figure
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