The Kingship Motif in the Near Eastern Cultures and in the Psalms

The problem which is presented, the problem of kingship in the Psalms, is not a theme that rises to the top in the Old Testament with any prominence. Yet it will be noticed that throughout the Near East the king played a decidedly important role in community and national life

Early Israel as the Kingdom of Yahweh

Archaeological evidence indicates that early Israel as the kingdom of Yahweh functioned on the analogy of Ancient Near Eastern vassal states. In the religion of Early Israel both law and warfare were vehicles for the extension of Yahweh\u27s covenant rule

The Study and Interpretation of the Old Testament

The subtitle of this study might well be: Prisoners of Hope: New Perspectives for the Study of Old Testament History and Theology. The single Biblical occurrence of the phrase, prisoners of hope” is located in a messenger speech (Botenspruch) in Zechariah 9:11-13

Design of biochemical pattern forming systems from minimal motifs

Although molecular self-organization and pattern formation are key features of life, only very few pattern-forming biochemical systems have been identified that can be reconstituted and studied in vitro under defined conditions. A systematic understanding of the underlying mechanisms is often hampered by multiple interactions, conformational flexibility and other complex features of the pattern forming proteins. Because of its compositional simplicity of only two proteins and a membrane, the MinDE system from Escherichia coli has in the past years been invaluable for deciphering the mechanisms of spatiotemporal self-organization in cells. Here, we explored the potential of reducing the complexity of this system even further, by identifying key functional motifs in the effector MinE that could be used to design pattern formation from scratch. In a combined approach of experiment and quantitative modeling, we show that starting from a minimal MinE-MinD interaction motif, pattern formation can be obtained by adding either dimerization or membrane-binding motifs. Moreover, we show that the pathways underlying pattern formation are recruitment-driven cytosolic cycling of MinE and recombination of membrane-bound MinE, and that these differ in their in vivo phenomenology

A genetically encodable cell-type-specific protein synthesis inhibitor

Chemical inhibitors have revealed requirements for protein synthesis that drive cellular plasticity. We developed a genetically encodable protein synthesis inhibitor (gePSI) to achieve cell-type-specific temporal control of protein synthesis. Controlled expression of the gePSI in neurons or glia resulted in rapid, potent and reversible cell-autonomous inhibition of protein synthesis. Moreover, gePSI expression in a single neuron blocked the structural plasticity induced by single-synapse stimulation

Continuum Model for River Networks

The effects of erosion, avalanching and random precipitation are captured in a simple stochastic partial differential equation for modelling the evolution of river networks. Our model leads to a self-organized structured landscape and to abstraction and piracy of the smaller tributaries as the evolution proceeds. An algebraic distribution of the average basin areas and a power law relationship between the drainage basin area and the river length are found.Comment: 9 pages, Revtex 3.0, 7 figures in compressed format using uufiles command, to appear in Phys. Rev. Lett., for an hard copy or problems e-mail to [email protected]

The translatome of neuronal cell bodies, dendrites,and axons

To form synaptic connections and store information, neurons continuously remodel their proteomes. The impressive length of dendrites and axons imposes logistical challenges to maintain synaptic proteins at locations remote from the transcription source (the nucleus). The discovery of thousands of messenger RNAs (mRNAs) near synapses suggested that neurons overcome distance and gain autonomy by producing proteins locally. It is not generally known, however, if, how, and when localized mRNAs are translated into protein. To investigate the translational landscape in neuronal subregions, we performed simultaneous RNA sequencing (RNA-seq) and ribosome sequencing (Ribo-seq) from microdissected rodent brain slices to identify and quantify the transcriptome and translatome in cell bodies (somata) as well as dendrites and axons (neuropil). Thousands of transcripts were differentially translated between somatic and synaptic regions, with many scaffold and signaling molecules displaying increased translation levels in the neuropil. Most translational changes between compartments could be accounted for by differences in RNA abundance. Pervasive translational regulation was observed in both somata and neuropil influenced by specific mRNA features (e.g., untranslated region [UTR] length, RNA-binding protein [RBP] motifs, and upstream open reading frames [uORFs]). For over 800 mRNAs, the dominant source of translation was the neuropil. We constructed a searchable and interactive database for exploring mRNA transcripts and their translation levels in the somata and neuropil [MPI Brain Research, The mRNA translation landscape in the synaptic neuropil. https://public.brain.mpg.de/dashapps/localseq/ Accessed 5 October 2021]. Overall, our findings emphasize the substantial contribution of local translation to maintaining synaptic protein levels and indicate that on-site translational control is an important mechanism to control synaptic strength

Wittgenstein's Thought Experiments and Relativity Theory

In this paper, I discuss the similarity between Wittgenstein’s use of thought experiments and Relativity Theory. I begin with introducing Wittgenstein’s idea of “thought experiments” and a tentative classification of different kinds of thought experiments in Wittgenstein’s work. Then, after presenting a short recap of some remarks on the analogy between Wittgenstein’s point of view and Einstein’s, I suggest three analogies between the status of Wittgenstein’s mental experiments and Relativity theory: the topics of time dilation, the search for invariants, and the role of measuring tools in Special Relativity. This last point will help to better define Wittgenstein’s idea of description as the core of his philosophical enterprise

Inventory - forecasting: mind the gap

We are concerned with the interaction and integration between demand forecasting and inventory control, in the context of supply chain operations. The majority of the literature is fragmented. Forecasting research more often than not assumes forecasting to be an end in itself, disregarding any subsequent stages of computation that are needed to transform forecasts into replenishment decisions. Conversely, most contributions in inventory theory assume that demand (and its parameters) are known, in effect disregarding any preceding stages of computation. Explicit recognition of these shortcomings is an important step towards more realistic theoretical developments, but still not particularly helpful unless they are somehow addressed. Even then, forecasts often constitute exogenous variables that serially feed into a stock control model. Finally, there is a small but growing stream of research that is explicitly built around jointly tackling the inventory forecasting question. We introduce a framework to define four levels of integration: from disregarding, to acknowledging, to partly addressing, to fully understanding the interactions. Focusing on the last two, we conduct a structured review of relevant (integrated) academic contributions in the area of forecasting and inventory control and argue for their classification with regard to integration. We show that the development from one level to another is in many cases chronological in order, but also associated with specific schools of thought. We also argue that although movement from one level to another adds realism, it also adds complexity in terms of actual implementations, and thus a trade-off exists. The article makes a contribution into an area that has always been fragmented despite the importance of bringing the forecasting and inventory communities together to solve problems of common interest. We close with an indicative agenda for further research and a call for more theoretical contributions, but also more work that would help to expand the empirical knowledge base in this area