The Crisis of the Late Third Millennium B.C: Ecofactual and Artificial Evidence From Umm el-Marra and the Jabbul Plain

This article presents a reading of the data of Umm el-Marra (plain Jabbul, western Syria), relating to the transition from the Bronze Age and Middle Bronze Age may contribute to the identification of a crisis during this period. Results of analyzes archaeobotanical, published for the first time, are also discussed. In Umm el-Marra, social, economic and cultural changes coincide with a change in material culture during the transition BA - BM; in some cases, it seems plausible to associate these changes to a crisis by crossing the complex local companies, but other interpretations are also possible. Among these, it is possible that around 2000 BC. AD Umm el Marra was abandoned temporarily and V that the earliest occupation of Middle Bronze is relatively small extension. The ideological and political change is illustrated by the abandonment of mortuary complex Bronze final of the Acropolis ancient site, for an elite, and by changes in mortuary practices between the Bronze Age and Middle Bronze Age. Economic innovations are evident in the Middle Bronze Age in the significant increase in the hunting of wild animals, especially horses, a practice that can be interpreted as a response to a natural or social environment experiencing high stress. Alongside this development, archaeobotanical data indicate a change in feed-related practices. The decline in occupancy in the semi-arid part of the Eastern Jabbul during the transition BA - BM could be interpreted as indicative of a crisis; this, however, like the other mentioned here needs to be deepened by further research

Mobility and connection among the Early Bronze Age Syrian elite

The archaeological site of Umm el-Marra (in the Jabbul plain, western Syria), is a large, fortified urban center. Excavations have uncovered ten tomb structures built during the Early Bronze Age (ca. 2600–2150 BCE) that possibly contain royalty as evidenced by lavish grave goods and paleopathological evidence suggesting sociocultural buffering from the harsh social and physical environments of agricultural urban centers in the Bronze Age Near East. Inside adjacent brick installations are animal (primarily equid) skeletons interpreted as interments, possibly sacrifices in some instances, as part of ceremonies honoring the entombed. The burial site was eventually re-used as evidenced by a monumental platform above the tombs, interpreted as use for ritual activities of ancestor veneration. This study analyzed 87Sr/86Sr and δ18O values from enamel of 13 individuals interred in these tombs, along with enamel and bone samples from animals found in and around the tomb structures. Six of 13 (43 %) individuals analyzed in these tombs are identified as non-locals. Although contemporaneous data in the northern Levant is scarce, we see much higher evidence of human movement at Umm el-Marra compared to others. Only elites are included in this study, but their relative mobility might imply that the ancient city established its position as a secondary center along major trade routes through intermarriage and connectivity. The concept of ‘social memory’ is evident, as the lives and deaths of these elites are integrated into this site where ancestor veneration is evidenced in centuries following interment

Excavation and Survey in the Jabbul Plain, Western Syria: The Umm el-Marra Project 1996-1997

The 1996 and 1997 seasons of the Hopkins-Amsterdam project in the Jabbul plain, western Syria, have generated new results on Bronze Age urbanism at Tell Umm el- Marra and elucidated longer-term settlement patterns in the Jabbul region. Excavation results have documented the foundation of Umm el-Marra as a regional center in the Early Bronze Age, provided new data on a period of decentralization in Middle Bronze I, and supplied evidence of the regeneration of urbanism in MB II. Faunal and archaeobotanical analysis broaden our understanding of these developments, attesting to an economy overwhelmingly dependent on the steppe environment, with an emphasis on large-scale onager hunting in MB II. Finally, a regional survey provides data on long-term demographic and socioeconomic trends, furnishing an expansive time range and spatial context for our under- standing of developmental patterns in the region. The survey results supply new information on the limits of the Uruk expansion, cycles of Bronze Age urbanization, changing patterns of steppe exploitation, and demo- graphic and agricultural extensification in the Byzantine and Early Islamic periods

Dynamics of putative raft-associated proteins at the cell surface

Lipid rafts are conceptualized as membrane microdomains enriched in cholesterol and glycosphingolipid that serve as platforms for protein segregation and signaling. The properties of these domains in vivo are unclear. Here, we use fluorescence recovery after photobleaching to test if raft association affects a protein's ability to laterally diffuse large distances across the cell surface. The diffusion coefficients (D) of several types of putative raft and nonraft proteins were systematically measured under steady-state conditions and in response to raft perturbations. Raft proteins diffused freely over large distances (>4 μm), exhibiting Ds that varied 10-fold. This finding indicates that raft proteins do not undergo long-range diffusion as part of discrete, stable raft domains. Perturbations reported to affect lipid rafts in model membrane systems or by biochemical fractionation (cholesterol depletion, decreased temperature, and cholesterol loading) had similar effects on the diffusional mobility of raft and nonraft proteins. Thus, raft association is not the dominant factor in determining long-range protein mobility at the cell surface

Delivery Site of Perivascular Endothelial Cell Matrices Determines Control of Stenosis in a Porcine Femoral Stent Model

PURPOSE: High restenosis rates are a major limitation of peripheral interventions. Endothelial cells, grown within gelatin matrices and implanted onto the adventitia of injured vessels, inhibit stenosis in experimental models. To determine if this technology could be adapted for minimally invasive procedures, we compared the effects of cells in an implantable sponge to an injectable formulation and investigated the importance of delivery site in a stent model. MATERIALS AND METHODS: Stents were implanted in the femoral arteries of 30 pigs followed by perivascular implantation of sponges or injection of particles containing allogeneic endothelial cells. Controls received acellular matrices or nothing. The effects of delivery site were assessed by injecting cellular matrices into or adjacent to the perivascular tissue, or into the neighboring muscle. Animals were sacrificed after 28 days. Pre-sacrifice angiograms and tissue sections were evaluated for stenosis. RESULTS: Arteries treated with cellular matrices had a 55 – 63% decrease in angiographic stenosis (P<0.05) and a 38 – 43% reduction (P<0.05) in histologic stenoses compared to controls. Intimal area was greatest when cellular matrices were delivered into the muscle (6.35 ± 0.95 mm2) compared to into or adjacent to the perivascular tissue (4.05 ± 0.56 mm2 and 4.73 ± 0.53 mm2, respectively, P < 0.05). CONCLUSIONS: Perivascular endothelial-cell matrices reduced stenosis after stent-induced injury. The effects were not dependent on the formulation but appeared to be dependent upon delivery site. Minimally invasive injections of endothelial-cell matrices to the adventitia of arteries following peripheral interventions may decrease restenosis rates.National Institutes of Health (U.S.) (Grant GM 49039

Assessment and prevention of acute health effects of weather conditions in Europe, the PHEWE project: background, objectives, design

<p>Abstract</p> <p>Background</p> <p>The project "Assessment and prevention of acute health effects of weather conditions in Europe" (PHEWE) had the aim of assessing the association between weather conditions and acute health effects, during both warm and cold seasons in 16 European cities with widely differing climatic conditions and to provide information for public health policies.</p> <p>Methods</p> <p>The PHEWE project was a three-year pan-European collaboration between epidemiologists, meteorologists and experts in public health. Meteorological, air pollution and mortality data from 16 cities and hospital admission data from 12 cities were available from 1990 to 2000. The short-term effect on mortality/morbidity was evaluated through city-specific and pooled time series analysis. The interaction between weather and air pollutants was evaluated and health impact assessments were performed to quantify the effect on the different populations. A heat/health watch warning system to predict oppressive weather conditions and alert the population was developed in a subgroup of cities and information on existing prevention policies and of adaptive strategies was gathered.</p> <p>Results</p> <p>Main results were presented in a symposium at the conference of the International Society of Environmental Epidemiology in Paris on September 6^th2006 and will be published as scientific articles. The present article introduces the project and includes a description of the database and the framework of the applied methodology.</p> <p>Conclusion</p> <p>The PHEWE project offers the opportunity to investigate the relationship between temperature and mortality in 16 European cities, representing a wide range of climatic, socio-demographic and cultural characteristics; the use of a standardized methodology allows for direct comparison between cities.</p

A Longitudinal Analysis of Volunteerism Activities for Individuals Educated in Public and Private Schools

Previous studies offer evidence that U.S. public and private high schools differentially influence volunteerism in adolescence. However, these studies are typically cross-sectional and only consider whether the individual volunteered or not. We address patterns of volunteering from adolescence into adulthood and the kind of volunteering activity in which individuals engage. We also theorize that distinctive civic values within public and private schools together with their respective organizational ties to other civic organizations channel students into particular volunteering activities. Relying on a longitudinal, nationally-representative sample of U.S. adolescents, we track volunteering from adolescence into young adulthood and identify the types of volunteering activities in which respondents engage. Results demonstrate that the likelihood of volunteering changes through the life course, and students from different schooling backgrounds systematically sort into specific volunteering activities as our theories predict

How does one become spiritual? The Spiritual Modeling Inventory of Life Environments (SMILE)

We report psychometric properties, correlates and underlying theory of the Spiritual Modeling Index of Life Environments (SMILE), a measure of perceptions of spiritual models, defined as everyday and prominent people who have functioned for respondents as exemplars of spiritual qualities, such as compassion, self-control, or faith. Demographic, spiritual, and personality correlates were examined in an ethnically diverse sample of college students from California, Connecticut, and Tennessee (N=1010). A summary measure of model influence was constructed from perceived models within family, school, religious organization, and among prominent individuals from both tradition and media. The SMILE, based on concepts from Bandura\u27s (1986) Social Cognitive Theory, was well-received by respondents. The summary measure demonstrated good 7-week test/retest reliability (r=.83); patterns of correlation supporting convergent, divergent, and criterion-related validity; demographic differences in expected directions; and substantial individual heterogeneity. Implications are discussed for further research and for pastoral, educational, and health-focused interventions