HUMAN RESOURCES/RURAL POVERTY

Food Security and Poverty,

Evaluation of the benefits of transnational transportation projects

In this paper an analytical framework has been developed to evaluate the primary beneficiaries of cargo traffic generated by transnational transport projects. In the transportation economics literature, the economic impact of infrastructure projects on cargo traffic has not been developed as fully as for passenger traffic. In much of the previous literature it is often assumed that consumers of the traded goods would receive the full benefits from the reduction in logistics and transportation costs. This paper has shown that whether the goods are traded internationally or regionally is a key factor in the allocation of the economic benefits arising from the reduction in the cost of cargo transportation. The analytical framework developed in the paper is applied to the evaluation of the impacts of the proposed Buenos Aires-Colonia binational bridge project.Argentina, Uruguay, cargo traffic, transnational, transportation benefits

Assessment of Black Carbon in Snow and Ice from the Tibetan Plateau and Pacific Northwest

An ice core from Mt. Geladandong, Tibetan Plateau, spanning 1853-1983, and snow samples collected over two winters from the Cascade Mountains were analyzed for concentrations of black carbon (BC) using a Single Particle Soot Photometer (SP2). From the ice core, the high-resolution BC record displayed substantial variability, a 2-fold increase in peak concentrations from 1853-1930 to 1930-1983, and a 1.6-fold increase in average concentrations from 1853-1975 to 1975-1983. Concentrations were also higher than at two areas closer to BC sources and analyzed by the same method. In the Pacific Northwest, BC concentrations varied seasonally and annually, with the highest concentrations in the first winter (2010) and spring of both years. Estimates for BC-induced reductions in albedo ranged from 0.1-5.5% for both sites, and may be high enough to impact on snow, ice, and water resources when analytical uncertainties, the timing of reductions, and the potential for feedback cycles are considered

Advanced cardiovascular risk prediction in the emergency department: updating a clinical prediction model - a large database study protocol.

From Europe PMC via Jisc Publications RouterHistory: ppub 2021-10-01, epub 2021-10-07Publication status: PublishedFunder: Department of Health; Grant(s): NIHR300246Funder: national institute for health research; Grant(s): NIHR300246BackgroundPatients presenting with chest pain represent a large proportion of attendances to emergency departments. In these patients clinicians often consider the diagnosis of acute myocardial infarction (AMI), the timely recognition and treatment of which is clinically important. Clinical prediction models (CPMs) have been used to enhance early diagnosis of AMI. The Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid is currently in clinical use across Greater Manchester. CPMs have been shown to deteriorate over time through calibration drift. We aim to assess potential calibration drift with T-MACS and compare methods for updating the model.MethodsWe will use routinely collected electronic data from patients who were treated using TMACS at two large NHS hospitals. This is estimated to include approximately 14,000 patient episodes spanning June 2016 to October 2020. The primary outcome of acute myocardial infarction will be sourced from NHS Digital's admitted patient care dataset. We will assess the calibration drift of the existing model and the benefit of updating the CPM by model recalibration, model extension and dynamic updating. These models will be validated by bootstrapping and one step ahead prequential testing. We will evaluate predictive performance using calibrations plots and c-statistics. We will also examine the reclassification of predicted probability with the updated TMACS model.DiscussionCPMs are widely used in modern medicine, but are vulnerable to deteriorating calibration over time. Ongoing refinement using routinely collected electronic data will inevitably be more efficient than deriving and validating new models. In this analysis we will seek to exemplify methods for updating CPMs to protect the initial investment of time and effort. If successful, the updating methods could be used to continually refine the algorithm used within TMACS, maintaining or even improving predictive performance over time.Trial registrationISRCTN number: ISRCTN41008456

Physiological Responses Underlying the Perception of Effort during Moderate and Heavy Intensity Cycle Ergometry

This study examined patterns of responses for physiological and perceptual variables during cycle ergometry at a constant rate of perceived exertion (RPE) within the moderate and heavy exercise intensity domains. Nineteen (mean age 21.3 ± 0.5 years; 43.4 ± 2.0 mL·kg−1·min−1 VO2Peak) moderately trained cyclists performed an incremental test to exhaustion and two 60 min constant RPE rides at the RPE corresponding to the gas exchange threshold (RPEGET) and 15% above the GET (RPEGET+15%). Oxygen consumption (VO2), respiratory exchange ratio (RER), heart rate (HR), minute ventilation (VE), breathing frequency (FB), and power output (PO) were monitored throughout the rides. Polynomial regression analyses showed VO2, RER, HR, and VE (correlation = −0.85 to −0.98) tracked the decreases in PO required to maintain a constant RPE. Only FB tracked RPE during the moderate and heavy intensity rides. Repeated measures ANOVAs indicated that VO2 during the 60 min rides at RPEGET was not different (p \u3e 0.05) from VO2 at GET from the incremental test to exhaustion. Thus, monitoring intensity using an RPE associated with the GET is sustainable for up to 60 min of cycling exercise and a common mechanism may mediate FB and the perception of effort during moderate and heavy intensity cycle ergometry

Physiological Responses Underlying the Perception of Effort during Moderate and Heavy Intensity Cycle Ergometry

This study examined patterns of responses for physiological and perceptual variables during cycle ergometry at a constant rate of perceived exertion (RPE) within the moderate and heavy exercise intensity domains. Nineteen (mean age 21.3 ± 0.5 years; 43.4 ± 2.0 mL·kg−1·min−1 VO2Peak) moderately trained cyclists performed an incremental test to exhaustion and two 60 min constant RPE rides at the RPE corresponding to the gas exchange threshold (RPEGET) and 15% above the GET (RPEGET+15%). Oxygen consumption (VO2), respiratory exchange ratio (RER), heart rate (HR), minute ventilation (VE), breathing frequency (FB), and power output (PO) were monitored throughout the rides. Polynomial regression analyses showed VO2, RER, HR, and VE (correlation = −0.85 to −0.98) tracked the decreases in PO required to maintain a constant RPE. Only FB tracked RPE during the moderate and heavy intensity rides. Repeated measures ANOVAs indicated that VO2 during the 60 min rides at RPEGET was not different (p \u3e 0.05) from VO2 at GET from the incremental test to exhaustion. Thus, monitoring intensity using an RPE associated with the GET is sustainable for up to 60 min of cycling exercise and a common mechanism may mediate FB and the perception of effort during moderate and heavy intensity cycle ergometry

The effects of anatabine on non-invasive indicators of muscle damage: a randomized, double-blind, placebo-controlled, crossover study

Background: Anatabine (ANA), a minor tobacco alkaloid found in the Solanaceae family of plants, may exhibit anti-inflammatory activity, which may be useful to aid in recovery from exercise-induced muscle damage. The purpose of this study, therefore, was to examine the effects of ANA supplementation on the recovery of isometric strength and selected non-invasive indicators of muscle damage. Methods: A double-blinded, placebo-controlled, crossover design was used to study eighteen men (mean ± SD age = 22.2 ± 3.1 yrs; body mass = 80.3 ± 15.7 kg) who participated in two randomly-ordered conditions separated by a washout period. The ANA condition consisted of consuming 6–12 mg anatabine per day for 10 days, while testing took place during days 7–10. The placebo (PLA) condition was identical except that the PLA supplement contained no ANA. Maximal voluntary isometric peak torque (PT) of the forearm flexors, arm circumference, hanging joint angle, and subjective pain ratings were measured before (PRE), immediately after (POST), and 24, 48, and 72 h after six sets of 10 maximal, eccentric isokinetic forearm flexion muscle actions. Resting heart rate and blood pressure were measured at PRE and 72 h in each condition. Results: For PT, hanging joint angle, arm circumference, and subjective pain ratings, there were no condition x time (p \u3e 0.05) interactions, there were no main effects for condition (p \u3e 0.05), but there were main effects for time (p \u3c 0.001). There were no condition x time (p \u3e 0.05) interactions and no main effects for condition (p \u3e 0.05) or time (p \u3e 0.05) for blood pressure or resting heart rate. Conclusions: ANA supplementation had no effect on the recovery of muscle strength, hanging joint angle, arm swelling, or subjective pain ratings after a bout of maximal eccentric exercise in the forearm flexors. Therefore, ANA may not be beneficial for those seeking to improve recovery from heavy eccentric exercise. Future studies should examine the effects of ANA on the pro-inflammatory cytokine responses to exercise-induced muscle damage and the chronic low-grade inflammation observed in obese and elderly individuals

ColdZyme® Mouth Spray reduces duration of upper respiratory tract infection symptoms in endurance athletes under free living conditions

Upper respiratory tract infection (URTI) can compromise athlete preparation and performance, so countermeasures are desirable. The aim of this study was to assess the effects of ColdZyme® Mouth Spray (ColdZyme) on self-reported upper respiratory tract infection in competitive endurance athletes under free-living conditions. One hundred and twenty-three endurance-trained, competitive athletes (recruited across 4 sites in England, UK) were randomised to control (no treatment, n = 61) or ColdZyme (n = 62) for a 3-month study period (between December 2017 – February 2018; or December 2018 – April 2019). They recorded daily training and illness symptoms (Jackson common cold questionnaire) during the study period. A total of 130 illness episodes were reported during the study with no difference in incidence between groups (episodes per person: 1.1 ± 0.9 Control, 1.0 ± 0.8 ColdZyme, P = 0.290). Episode duration was significantly shorter in ColdZyme compared to Control: Control 10.4 ± 8.5 days vs ColdZyme 7.7 ± 4.0 days, P = 0.016). Further analysis to compare episodes with poor vs good compliance with ColdZyme instructions for use (IFU) within the ColdZyme group showed a further reduction in duration of URTI when compliance was good (9.3 ± 4.5 days in ColdZyme poor IFU compliance vs 6.9 ± 3.5 days in ColdZyme good IFU compliance, P = 0.040). ColdZyme may be an effective countermeasure to reduce URTI duration, which was significantly lower (by 26-34%) in the ColdZyme treatment group (with no influence on incidence). This may have implications for athlete performance