Knowledge Extraction and Prediction from Behavior Science Randomized Controlled Trials: A Case Study in Smoking Cessation

Due to the fast pace at which randomized controlled trials are published in the health domain, researchers, consultants and policymakers would benefit from more automatic ways to process them by both extracting relevant information and automating the meta-analysis processes. In this paper, we present a novel methodology based on natural language processing and reasoning models to 1) extract relevant information from RCTs and 2) predict potential outcome values on novel scenarios, given the extracted knowledge, in the domain of behavior change for smoking cessation

HBCP Corpus: A New Resource for the Analysis of Behaviour Change Intervention Reports

Due to the fast pace at which research reports in behaviour change are published, researchers, consultants and policymakers would benefit from more automatic ways to process these reports. Automatic extraction of the reports’ intervention content, population, settings and their results etc. are essential in synthesising and summarising the literature. However, to the best of our knowledge, no unique resource exists at the moment to facilitate this synthesis. In this paper, we describe the construction of a corpus of published behaviour change intervention evaluation reports aimed at smoking cessation. We also describe and release the annotation of 57 entities, that can be used as an off-the-shelf data resource for tasks such as entity recognition, etc. Both the corpus and the annotation dataset are being made available to the community.Wellcome Trust collaborative awar

Shear Strength Parameters of Improved Peat by Chemical Stabilizer.

The present research aimed to discuss the applicability of cationic grouts in geotechnical engineering. The effects of several cationic stabilizers such as monovalent (sodium silicate), divalent (calcium oxide and calcium chloride), and trivalent (aluminum hydroxide) were investigated on shear strength improvement of tropical peat samples. The unconfined compressive strength (UCS) tests were performed after the time frame of 7, 21, and 30 days as curing time, respectively. Apart from the physicochemical characteristics of the stabilized peat, scanning electron microscopy and energy-dispersive X-ray spectroscopy tests were also carried out to study the ongoing microstructural changes. It is to be noted that the shear strength values for peat samples rose to 8, 6, 6, and 4 % of sodium silicate, calcium oxide, calcium chloride, and aluminum hydroxide, respectively. The highest observed UCS outcome is the one taken from the calcium oxide where the UCS of treated peat after 30-day curing time increased to 76 kPa. The strength changes resulted from the various cationic stabilizers can best be explained via the consideration within the mineralogical composition as well as those physicochemical changes happening in the peat

Populism, inequality and representation: Negotiating ‘the 99%’ with Occupy London

When Occupy London emerged with a global wave of protest movements in October 2011, it embodied and advanced discursive forms that have characterised the unsettling of political consensus following the financial crisis. The central claim that ‘We are the 99%’ staged a fundamental tension, between a populist appeal to the figure of ‘the people’, and a contrary orientation seeking to critique inequality while rejecting forms of representation and identity. This article – which draws on three years of ethnographic fieldwork with Occupy London (October 2011–October 2014) and a critical theorisation of the figure of ‘the people’ in radical movements – follows movement participants’ negotiation of the tension at the heart of the discourse of ‘the 99%’. It offers an account of the conflicting meanings and practices that emerged, arguing that the result was a creative contradiction that sustained the movement for a time, while setting the terms of its ultimate breakdown. Identifying the concept of ‘representation’ as the site of particular controversy, this is unpicked through a number of key figures (Pitkin, Marx, Spivak, Puchner, Deleuze and Guattari) as the basis for an empirical account of Occupy’s practice of assembly, which offered partial, imperfect ‘solutions’ to these tensions. The article concludes with some implications for the limits and possibilities of both a grassroots populism and a politics against representation, in the context of political developments since

Extracellular and Luminal pH Regulation by Vacuolar H⁺-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes

Plasma membrane vacuolar H+ -ATPase (pm-V-ATPase) activity of tumor cells is a major factor in control of cytoplasmic and extracellular pH and metastatic potential, but the isoforms involved and the factors governing plasma membrane recruitment remain uncertain. Here, we examined expression, distribution and activity of V- ATPase isoforms in invasive prostate adenocarcinoma (PC-3) cells. Isoforms 1 and 3 were the most highly expressed forms of membrane subunit a, with a1 and a3 the dominant plasma membrane isoforms. Correlation between pm-V-ATPase activity and invasiveness was limited, but RNAi knockdown of either a isoform did slow cell proliferation and inhibit invasion in vitro. Isoform a1 was recruited to the cell surface from the early endosome/recycling complex pathway, its knockdown arresting transferrin receptor (TfR) recycling. Isoform a3 was associated with the late endosomal/lysosomal compartment. Both a isoforms associated with accessory protein Ac45, knockdown of which stalled transit of a1 and Tf-TfR, decreased proton efflux and reduced cell growth and invasiveness, this latter effect at least partly due to decreased delivery of the membrane-bound matrix metalloproteinase MMP-14 to the plasma membrane. These data indicate that in prostatic carcinoma cells, a1 and a3 isoform populations predominate in different compartments where they maintain different luminal pH. Ac45 plays a central role in navigating the V-ATPase to the plasma membrane, and hence is an important factor in expression of the invasive phenotype

Resolved E-symmetry zone-centre phonons in LiTaO3 and LiNbO3

International audienc