3,333 research outputs found
Consideration of radar target glint from ST during OMV rendezvous
The nature of radar target glint and the factors upon which it depends when using the Hubble Space Telescope as a radar target is discussed. An analysis of the glint problem using a 35 MHz or 94 MHz radar on the orbital maneuvering vehicle is explored. A strategy for overcoming glint is suggested
From Classical to Quantum Mechanics: "How to translate physical ideas into mathematical language"
In this paper, we investigate the connection between Classical and Quantum
Mechanics by dividing Quantum Theory in two parts: - General Quantum Axiomatics
(a system is described by a state in a Hilbert space, observables are
self-adjoint operators and so on) - Quantum Mechanics properly that specifies
the Hilbert space, the Heisenberg rule, the free Hamiltonian... We show that
General Quantum Axiomatics (up to a supplementary "axiom of classicity") can be
used as a non-standard mathematical ground to formulate all the ideas and
equations of ordinary Classical Statistical Mechanics. So the question of a
"true quantization" with "h" must be seen as an independent problem not
directly related with quantum formalism. Moreover, this non-standard
formulation of Classical Mechanics exhibits a new kind of operation with no
classical counterpart: this operation is related to the "quantization process",
and we show why quantization physically depends on group theory (Galileo
group). This analytical procedure of quantization replaces the "correspondence
principle" (or canonical quantization) and allows to map Classical Mechanics
into Quantum Mechanics, giving all operators of Quantum Mechanics and
Schrodinger equation. Moreover spins for particles are naturally generated,
including an approximation of their interaction with magnetic fields. We find
also that this approach gives a natural semi-classical formalism: some exact
quantum results are obtained only using classical-like formula. So this
procedure has the nice property of enlightening in a more comprehensible way
both logical and analytical connection between classical and quantum pictures.Comment: 47 page
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"Call a Teenager… That's What I Do!" - Grandchildren Help Older Adults Use New Technologies: Qualitative Study.
BackgroundAlthough family technical support seems intuitive, there is very little research exploring this topic.ObjectiveThe objective of this study was to conduct a subanalysis of data collected from a large-scale qualitative project regarding older adults' experiences in using health information technology. Specifically, the subanalysis explored older adults' experiences with technology support from family members to inform strategies for promoting older adults' engagement with new health technologies. Although the primary analysis of the original study was theoretically driven, this paper reports results from an inductive, open-coding analysis.MethodsThis is a subanalysis of a major code identified unexpectedly from a qualitative study investigating older adults' use experience of a widespread health technology, the patient portal. A total of 24 older patients (≥65 years) with multiple chronic conditions (Charlson Comorbidity Index >2) participated in focus groups conducted at the patients' primary clinic. While conducting the primary theoretically driven analysis, coders utilized an open-coding approach to ensure important ideas not reflected in the theoretical code book were captured. Open coding resulted in 1 code: family support. This subanalysis further categorized family support by who provided tech support, how tech support was offered, and the opinions of older participants about receiving family tech support.ResultsThe participants were not specifically asked about family support, yet themes around family assistance and encouragement for technology emerged from every focus group. Participants repeatedly mentioned that they called their grandchildren and adult children if they needed help with technology. Participants also reported that family members experienced difficulty when teaching technology use. Family members struggled to explain simple technology tasks and were frustrated by the slow teaching process.ConclusionsThe results suggest that older adults ask their family members, particularly grandchildren, to support them in the use of new technologies. However, family may experience difficulties in providing this support. Older adults will be increasingly expected to use health technologies, and family members may help with tech support. Providers and health systems should consider potential family support and engagement strategies to foster adoption and use among older patients
Hot melt adhesive attachment pad
A hot melt adhesive attachment pad for releasably securing distinct elements together is described which is particularly useful in the construction industry or a spatial vacuum environment. The attachment pad consists primarily of a cloth selectively impregnated with a charge of hot melt adhesive, a thermo-foil heater, and a thermo-cooler. These components are securely mounted in a mounting assembly. In operation, the operator activates the heating cycle transforming the hot melt adhesive to a substantially liquid state, positions the pad against the attachment surface, and activates the cooling cycle solidifying the adhesive and forming a strong, releasable bond
Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington\u27s Disease
BACKGROUND: Previous studies suggest that Huntingtin, the protein mutated in Huntington\u27s disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes where it interacts with phospholipids involved in cell signaling. The small GTPase Rac1 is a downstream target of growth factor stimulation and PI 3-kinase activity and is critical for actin dependent membrane remodeling.
OBJECTIVE: To determine if Rac1 activity is impaired in HD or regulated by normal Huntingtin.
METHODS: Analyses were performed in differentiated control and HD human stem cells and HD Q140/Q140 knock-in mice. Biochemical methods included SDS-PAGE, western blot, immunoprecipitation, affinity chromatography, and ELISA based Rac activity assays.
RESULTS: Basal Rac1 activity increased following depletion of Huntingtin with Huntingtin specific siRNA in human primary fibroblasts and in human control neuron cultures. Human cells (fibroblasts, neural stem cells, and neurons) with the HD mutation failed to increase Rac1 activity in response to growth factors. Rac1 activity levels were elevated in striatum of 1.5-month-old HD Q140/Q140 mice and in primary embryonic cortical neurons from HD mice. Affinity chromatography analysis of striatal lysates showed that Huntingtin is in a complex with Rac1, p85alpha subunit of PI 3-kinase, and the actin bundling protein alpha-actinin and interacts preferentially with the GTP bound form of Rac1. The HD mutation reduced Huntingtin interaction with p85alpha.
CONCLUSIONS: These findings suggest that Huntingtin regulates Rac1 activity as part of a coordinated response to growth factor signaling and this function is impaired early in HD
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Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling.
Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We used integrative molecular profiling to discover and characterize molecular subtypes of LMS. Gene expression profiling was performed on 51 LMS samples. Unsupervised clustering showed three reproducible LMS clusters. Array comparative genomic hybridization (aCGH) was performed on 20 LMS samples and showed that the molecular subtypes defined by gene expression showed distinct genomic changes. Tumors from the muscle-enriched cluster showed significantly increased copy number changes (P=0.04). A majority of the muscle-enriched cases showed loss at 16q24, which contains Fanconi anemia, complementation group A, known to have an important role in DNA repair, and loss at 1p36, which contains PRDM16, of which loss promotes muscle differentiation. Immunohistochemistry (IHC) was performed on LMS tissue microarrays (n=377) for five markers with high levels of messenger RNA in the muscle-enriched cluster (ACTG2, CASQ2, SLMAP, CFL2 and MYLK) and showed significantly correlated expression of the five proteins (all pairwise P<0.005). Expression of the five markers was associated with improved disease-specific survival in a multivariate Cox regression analysis (P<0.04). In this analysis that combined gene expression profiling, aCGH and IHC, we characterized distinct molecular LMS subtypes, provided insight into their pathogenesis, and identified prognostic biomarkers
Local Quantum Measurement and No-Signaling Imply Quantum Correlations
We show that, assuming that quantum mechanics holds locally, the finite speed
of information is the principle that limits all possible correlations between
distant parties to be quantum mechanical as well. Local quantum mechanics means
that a Hilbert space is assigned to each party, and then all local
positive-operator-valued measurements are (in principle) available; however,
the joint system is not necessarily described by a Hilbert space. In
particular, we do not assume the tensor product formalism between the joint
systems. Our result shows that if any experiment would give nonlocal
correlations beyond quantum mechanics, quantum theory would be invalidated even
locally.Comment: Published version. 5 pages, 1 figure
Interactive Video: A Report from the ACE Western Regional Workshop
The ACE workgroup involved communicators, educators and subject specialists from a number of states and Canada
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