Recycling of Gold Tailings of Silicate-Carbonate Ores

The implementation of the method for extracting gold, including melting of silicate-carbonate technogenic material, showed that gold passes into a free state, and the size of its particles increases significantly. However, when the material melts, a significant amount of slag is formed, which must be disposed. The chemical composition of the slag was compared with the norms of approximate and maximum permissible concentration. The content of Cu, As, Sb, S, and Mn exceeds the established standards. When the melt is blown with air and natural gas, sulfur, arsenic, and antimony will pass into the gas phase. In this regard, the installation must be equipped with a dust and gas cleaning system. If 12 wt.% CaO is added to the initial mixture before melting, the slag will meet the requirements when it is used as a correcting additive in cement. © Published under licence by IOP Publishing Ltd.The research was supported by the Ministry of Science and Higher Education in accordance with the state assignment for Ural State Mining University No. 0833-2020-0008 “Development and environmental and economic substantiation of the technology for reclamation of land disturbed by the mining and metallurgical complex based on reclamation materials and fertilizers of a new type”. We obtain the scientific results using the equipment of the Centre for the collective use of scientific equipment of the Federal Scientific Centre of biological systems and agricultural technologies of RAS as well (No Ross RU.0001.21 PF59, the Unified Russian Register of Centres for Collective Use - http://www.ckp-rf.ru/ckp/77384)

Research on the readiness of preschool teachers for innovative activities

The article presents a study of the potential of teachers to implement innovations in their professional activities and factors hindering the transition to the mode of innovative development. The study revealed that, according to a number of indicators, the level of innovative readiness for mastering innovations among respondents is low, and that purposeful and systematic work is needed both from the management and the teachers in order to introduce innovations in preschool educational institutions. The study uses an integrated approach aimed at finding tools and methods of training preschool teachers with diverse social and intellectual needs, who are able to develop in their professional activities. Recommendations for the preparation of preschool teachers for innovative activities are presented.Исследован потенциал педагогов в отношении использования ими инноваций в своей профессиональной деятельности, а также в отношении факторов, препятствующих переходу в режим инновационного развития. Выявлено, что по ряду показателей у респондентов уровень инновационной готовности к освоению новшеств низкий и что для внедрения инноваций в дошкольных образовательных учреждениях необходима целенаправленная, систематическая работа как руководства, так и самих педагогов. В исследовании использован комплексный подход к поиску средств и способов подготовки педагогов дошкольного образования с разносторонними социальными и интеллектуальными потребностями, способных развиваться в процессе своей профессиональной деятельности. Даны рекомендации по подготовке педагогов дошкольного образования к инновационной деятельности

Migraine and sleep disorders: a systematic review

Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs. The existence of a relationship between migraine and sleep disorders has been recognized from centuries by clinicians and epidemiological studies. Nevertheless, the exact nature of this association, the underlying mechanisms and interactions are complex and not completely understood. Recent biochemical and functional imaging studies identified central nervous system structures and neurotransmitters involved in the pathophysiology of migraine and also important for the regulation of normal sleep architecture, suggesting a possible causative role, in the pathogenesis of both disorders, of a dysregulation in these common nervous system pathways. This systematic review summarizes the existing data on migraine and sleep disorders with the aim to evaluate the existence of a causal relationship and to assess the presence of influencing factors. The identification of specific sleep disorders associated with migraine should induce clinicians to systematically assess their presence in migraine patients and to adopt combined treatment strategies

Design activity as a formation condition student's civil identity

The article considers the need to realize the potential of students' project activities for the upbringing of civic identity.В статье рассматривается необходимость реализации потенциала проектной деятельности студентов для формирования гражданской идентичности

ОПЫТ СОЗДАНИЯ ЛИСТА ОЖИДАНИЯ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ В ЕКАТЕРИНБУРГЕ

Gaining the experience of liver transplantation waiting list formation is the important condition of transplant cen- ter successful work. In the era of transplant organ shortage careful medical examination of the patient before the operation and detection of unfavorable facts and transplantation contraindications are of paramount importance. At the same time evaluation of the structure of potential liver transplant recipients category allows to develop maximal effective management of waiting list patients and prevention of fatal complications before operation. Приобретение опыта формирования листа ожидания трансплантации печени является важным условием успеха работы трансплантационного центра. Тщательное обследование больного до операции позволяет своевременно выявить неблагоприятные факторы и противопоказания для трансплантации, что является особенно важным в условиях дефицита донорских органов. Вместе с тем изучение структуры категории больных, имеющих показания для пересадки печени, позволяет отработать максимально эффективную методику ведения их в листе ожидания и предупреждать развитие фатальных осложнений до операции.

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Background: Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. Methods: The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. Findings: We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2–11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75–1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58–1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91–1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70–1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11–0·20]; p<0·0001) and glucocorticoids alone (0·68 [0·50–0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38–0·67]; p<0·0001) or glucocorticoids alone (0·63 [0·45–0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups. Interpretation: Recovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries. Funding: Imperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Background Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. Methods The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. Findings We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2–11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75–1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58–1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91–1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70–1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11–0·20]; p<0·0001) and glucocorticoids alone (0·68 [0·50–0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38–0·67]; p<0·0001) or glucocorticoids alone (0·63 [0·45–0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups. Interpretation Recovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries. Funding Imperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health

The 'Sound' Phenomenon Paradigm as Musical and Educational Challenge

Sound phenomenon is an object studied in different fields of scientific knowledge: from the formation of Universal structures to a person's inner world. Command of sound's culture (in different epochs, peoples, musical directions, styles and schools) presents different images of the world in its correlation to a human. That is why mastering the culture of sound in performance and composing practices Achieving this aim can only be possible under one condition: the sound phenomenon and worldview are treated in the framework of paradigm approach. That is when models of sound and the outlook reflect common stance in posing problems by the society and understanding the ways of their treatment. This poses the problem of researching sound phenomenon paradigm shift and outlook as a complex process before musical education theory (Glazyrina, 2001). It is impossible to consider the sound phenomenon in theory of musical training out of context of understandings and attitudes of this or that artistic epoch (direction, style)-artistic and aesthetical concepts, theories of musical training, values and ideals, sound images and so on. However, it should be taken into account that in musical training, culture and art the shift of sound paradigms is much more complex than in science. That is why theory of musical training while studying the repertoire of concepts, technologies and teaching methods in the offgoing sequence of sound phenomenon paradigms should focus on their philosophical content. (C) 2018 Published by Future Academy www.FutureAcademy.org.U

THE EXPERIENCE OF WAITING LIST MANAGEMENT FOR LIVER TRANSPLANTATION IN EKATERINBURG

Gaining the experience of liver transplantation waiting list formation is the important condition of transplant cen- ter successful work. In the era of transplant organ shortage careful medical examination of the patient before the operation and detection of unfavorable facts and transplantation contraindications are of paramount importance. At the same time evaluation of the structure of potential liver transplant recipients category allows to develop maximal effective management of waiting list patients and prevention of fatal complications before operation