NICU EBP Project: Transitioning Caregivers to a Private Room NICU

To identify challenges, address concerns, and educate staff in order to make the transition to the utilization of private rooms in the NICU a smooth one.https://digitalcommons.centracare.com/nursing_posters/1024/thumbnail.jp

Everything is fiction: an experimental study in the application of ethnographic criticism to modern atheist identity

This Thesis is an experiment. Within its pages a number of stories will be told, the foci of which will apply a particular methodology—what I call ‘Ethnographic Criticism’—to the examination of a specific concept: modern Atheist identity. First, it will introduce Ethnographic Criticism as a new and significant style of literary analysis aimed at reading fictional texts in order to generate anthropological insights about how particular identities are formed. Second, it will use this new means of criticism to discuss and evaluate how Atheist identity might be perceived as being constructed within a dialectic between seemingly exclusive forms of Theism and Atheism. Ethnographic Criticism exists at the nexus between fiction and ethnography, and its genesis derives from three foundational pillars: ethnographic construction, Ethical Criticism, and discourse analysis. In the three Chapters of Part One, each of these pillars will be established, both exegetically and critically. This examination will play a key role in explicating how the ‘made-up’ qualities of fiction might be converted into the ‘made-from’ qualities of ethnography. Additionally, these Chapters will reveal the roots of Ethnographic Criticism through an analysis of discourses dealing with the ‘literary turn’ in the theory of anthropology, how Ethical Criticism associates fictional character development with identity construction, and the anthropological benefits of discourse analysis. As a case study, I will apply Ethnographic Criticism to an analysis of Atheist identity construction. Due to the combination of a relative absence of existing ethnographic sources on the subject, an ambiguous academic discourse on the definition of the term, and a paucity of cultural units or ‘tribes’ of Atheists in which to observe, my use of Ethnographic Criticism will attempt to fill a methodological lacuna concerning the study of Atheist identity. Thus, in Part Two, I will focus on two fictional texts by the contemporary English novelist Ian McEwan: Black Dogs (1992) and Enduring Love (1997). In this analysis, not only will McEwan’s fictional characters be treated as if they are ‘real,’ historical individuals, they will be evaluated through an anthropological lens in order to isolate within their interactional validations a means to understand how Atheists define themselves via dialectical communication. In this way, and in both explicating and reflecting upon this approach, my experimental analysis will identify a number of dynamic, yet no less precarious, outcomes that might surface from reading fictional texts as if they were authoritatively equal to ethnographic ones

Susceptibility and pathology in juvenile atlantic cod gadus morhua to a marine viral haemorrhagic septicaemia virus isolated from diseased rainbow trout oncorhynchus mykiss

The first known outbreak caused by a viral haemorrhagic septicaemia virus (VHSV) strain of genotype III in rainbow trout occurred in 2007 at a marine farm in Storfjorden, Norway. The source of the virus is unknown, and cod and other marine fish around the farms are suspected as a possible reservoir. The main objective of this study was to test the susceptibility of juvenile Atlantic cod to the VHSV isolate from Storfjorden. As the pathology of VHS in cod is sparsely described, an additional aim of the study was to give a histopathological description of the disease. Two separate challenge experiments were carried out, using both intra peritoneal (ip) injection and cohabitation as challenge methods. Mortality in the ip injection experiment leveled at approximately 50% three weeks post challenge. Both immunohistochemical and rRT-PCR analysis of organs sampled from diseased and surviving fish confirmed VHSV infection. No VHSV was detected in the cohabitants. The results indicate that Atlantic cod has a low natural susceptibility to this VHSV genotype III strain. One of the most extensive pathological changes was degeneration of cardiac myocytes. Immunohistochemistry confirmed that the lesions were related to VHSV. In some fish, the hematopoietic tissue of spleen and kidney showed degeneration and immunostaining, classical signs of VHS, as described in rainbow trout. Positive immunostaining of the capillaries of the gills, suggests this organ as a useful alternative when screening for VHSV.publishedVersio

IRES-Mediated Protein Translation Overcomes Suppression by the p14ARF Tumor Suppressor Protein.

Internal ribosome entry sites (IRES elements) have attracted interest in cancer gene therapy because they can be used in the design of gene transfer vectors that provide bicistronic co-expression of two transgene products under the control of a single promoter. Unlike cellular translation of most mRNAs, a process that requires a post-translational 5' modification of the mRNA known as the cap structure, IRES-mediated translation is independent of the cap structure. The cellular conditions that may intervene to modulate IRES-mediated, cap-independent versus cap-dependent translation, however, remain poorly understood, although they could be critical to the choice of gene transfer vectors. Here we have compared the effects of the p14ARF (Alternate Reading Frame) tumor suppressor, a translational suppressor frequently overexpressed in cancer, on cap-dependent translation versus cap-independent translation from the EMCV viral IRES often used in bicistronic gene transfer vectors. We find that ectopic overexpression of p14ARF suppresses endogenous and ectopic cap-dependent protein translation, consistent with other studies. However, p14ARF has little or no effect on transgene translation initiated within an IRES element. This suggests that transgenes placed downstream of an IRES element will retain efficient translation of their gene products in the presence of high levels of ectopic or endogenous p14ARF, a finding that could be particularly relevant to therapeutic gene therapy strategies for cancer

Thromboembolic events after high-intensity training duringcisplatin-based chemotherapy for testicular cancer: Casereports and review of the literature

The randomized “Testicular cancer and Aerobic and Strength Training trial” (TAST‐trial) aimed to evaluate the effect of high‐intensity interval training (HIIT) on cardiorespiratory fitness during cisplatin‐based chemotherapy (CBCT) for testicular cancer (TC). Here, we report on an unexpected high number of thromboembolic (TE) events among patients randomized to the intervention arm, and on a review of the literature on TE events in TC patients undergoing CBCT. Patients aged 18 to 60 years with a diagnosis of metastatic germ cell TC, planned for 3 to 4 CBCT cycles, were randomized to a 9 to 12 weeks exercise intervention, or to a single lifestyle counseling session. The exercise intervention included two weekly HIIT sessions, each with 2 to 4 intervals of 2 to 4 minutes at 85% to 95% of peak heart rate. The study was prematurely discontinued after inclusion of 19 of the planned 94 patients, with nine patients randomized to the intervention arm and 10 to the control arm. Three patients in the intervention arm developed TE complications; two with pulmonary embolism and one with myocardial infarction. All three patients had clinical stage IIA TC. No TE complications were observed among patients in the control arm. Our observations indicate that high‐intensity aerobic training during CBCT might increase the risk of TE events in TC patients, leading to premature closure of the TAST‐trial