i lepidotteri ropaloceri della montagnola senese siena toscana meridionale lepidoptera

Una ricerca ventennale (1991-2011) sulla ropalocerofauna della Montagnola Senese, un Sito d'importanza Comunitaria della Toscana meridionale, ha permesso di accertare la presenza di 97 specie, (15 Hesperiidae, 3 Papilionidae, 13 Pieride, 31 Lycaenidae, 35 Nymphalidae). Le specie più significative sono Pyrgus sidae (Esper, 1784), Carcharodus lavatherae (Esper, 1783), Lycaena thersamon (Esper, 1784), Satyrium w-album (Knoch, 1782), Cupido minimus (Fuessly, 1775), Phengaris arion (Linnaeus, 1758), Polyommatus daphnis (Denis & Schiffermuller, 1775), Polyommatus hispanus (Herrich-Schaffer, 1851) e Brenthis hecate (Denis & Schiffermuller, 1775), entità di valore conservazionistico o di interesse biogeografico. Particolarmente interessanti risultano C. minimus e P. daphnis poiché in nessun'altro comprensorio della Toscana meridionale risultano così abbondanti come nella Montagnola Senese. Gli habitat di maggior interesse sono le praterie xeriche, le garighe e gli ex coltivi ("insule coltivate") che ospitano oltre i tre quarti delle specie note per la Montagnola Senese. Anche le leccete, tuttavia, rivestono una certa importanza dal momento che ospitano entità di pregio faunistico e conservazionistico come S. w-album e Charaxes jasius (Linnaeus, 1767). La principale minaccia è rappresentata dall'attività estrattiva che determina perdita di habitat. La riduzione o la riprogrammazione delle attività di estrazione insieme alla tutela di praterie, garighe e "insule coltivate" si configurano come azioni fondamentali per garantire la sopravvivenza della ropalocerofauna della Montagnola Senese

The first European record of the Indonesian snakehead, Channa micropeltes (Actinopterygii: Perciformes: Channidae)

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Collezioni malacologiche e monitoraggi delle comunità di molluschi terrestri del Delta del Po e della Pianura Padana orientale: il Progetto CoSMoS – Collecting Snails, Monitoring Snails

The CoSMoS project is an initiative of Citizen Science with teaching and educational modules for students and citizens. The project examines the terrestrial molluscs (gastropods) in seven sites in the Po Delta and in the Eastern Po Valley (3 in the province of Ravenna and 4 in the province of Ferrara) and considers the monitoring and the comparison of current and historical faunal data. The latter can be derived from the malacological collection “Giorgio Lazzari” of the Natural History Museum of Ferrara. 51 species were collectively assessed, 44 of which were present in the historical surveys. Almost all species found are indigenous: only three are alien. From an ecological point of view, species closely linked to forest environments prevail, but there are also typical entities of other environments or very adaptable entities. From the biogeographical point of view, the most interesting result is the discovery, south of the Po, of two entities (Fruticicola fruticum and Monachoides incarnatus) which have a European distribution and in our country usually occur in Alpine and pre-Alpine area

Expression of Cellular and Extracellular TERRA, TERC and TERT in Hepatocellular Carcinoma

Non-coding RNAs are transcribed from telomeres and the telomeric repeat-containing RNAs (TERRA) are implicated in telomere homeostasis and in cancer. In this study, we aimed to assess in hepatocellular carcinoma (HCC) the cellular and extracellular expression of TERRA, the telomerase RNA subunit (TERC) and the telomerase catalytic subunit (TERT). We determined by qPCR the expression level of TERRA 1_2_10_13q, TERRA 15q, TERRA XpYp, TERC and of TERT mRNA in HCC tissues and in the plasma of HCC patients. Further, we profiled the same transcripts in the HCC cell lines, HA22T/VGH and SKHep1C3, and in the extracellular vesicles (EVs) derived from their secretomes. We found that the expression of TERRA and TERT mRNA was significantly deregulated in HCC, being TERRA downregulated and TERT mRNA upregulated in HCC tissues vs. the peritumoral (PT) ones, and the receiver operating characteristic (ROC) curve analyses revealed a significant ability in discriminating HCC from PT tissue. Further, the determinations of circulating TERRA and TERC showed higher amounts of these transcripts in the plasma of HCC patients vs. controls and ROC analyses gave significant results. The expression characterization of the cultured HCC cells showed their ability to produce and secrete TERRA and TERC into the EVs; the ability to produce TERT mRNA that was not detectable in the EVs; and the ability to respond to sorafenib treatment increasing TERRA expression. Our results highlight that: (i) both cellular and extracellular expressions of TERRA and TERC are dysregulated in HCC as well as the cellular expression of TERT mRNA and (ii) the combined detection of TERRA and TERC in plasma may represent a promising approach for non-invasive diagnostic molecular indicators of HCC

Atypical response of class IC atrial flutter to adenosine

We report the case of a 67-year-old female with a wide QRS complex tachycardia at 180 bpm. A diagnosis of class IC atrial flutter with aberrant ventricular conduction caused by flecainide therapy was formulated. Intravenous adenosine administration resulted in adequate slowing of the ventricular rate and normalization of QRS complexes. Restoration of sinus rhythm was achieved with intravenous amiodarone. The response to adenosine confirmed the diagnosis of supraventricular tachycardia with aberrant conduction, but the transition from arrhythmia onset to restoration of sinus rhythm showed interesting peculiarities

Adherence and Reactogenicity to Vaccines against SARS-COV-2 in 285 Patients with Neuropathy: A Multicentric Study

Background: The safety of the new vaccines against SARS-CoV-2 have already been shown, although data on patients with polyneuropathy are still lacking. The aim of this study is to evaluate the adherence to SARS-CoV-2 vaccination, as well as the reactogenicity to those vaccines in patients affected by neuropathy. Methods: A multicentric and web-based cross-sectional survey was conducted among patients affected by neuropathy from part of South Italy. Results: Out of 285 responders, n = 268 were included in the final analysis and n = 258 of them (96.3%) were fully vaccinated. Adherence to vaccination was higher in patients with hereditary neuropathies compared to others, while it was lower in patients with anti-MAG neuropathy (all p < 0.05). The overall prevalence of adverse events (AEs) was 61.2% and its occurrence was not associated with neuropathy type. Being female and of younger age were factors associated with higher risk of AEs, while having an inflammatory neuropathy and steroids assumption were associated with a lower risk (all p < 0.05). Younger age, having had an AE, and COVID-19 before vaccination were factors associated with symptoms worsening after vaccination (all p < 0.05). (4) Conclusions: Patients with neuropathy showed a high level of adherence to COVID-19 vaccination. Safety of vaccines in patients with neuropathies was comparable to the general population and it was more favorable in those with inflammatory neuropathy

Backdating systematic shell ornament making in Europe to 45,000 years ago.

Personal ornaments are commonly linked to the emergence of symbolic behavior. Although their presence in Africa dates back to the Middle Stone Age, evidence of ornament manufacturing in Eurasia are sporadically observed in Middle Palaeolithic contexts, and until now, large-scale diffusion has been well documented only since the Upper Palaeolithic. Nevertheless, little is known during the period between ca. 50,000 and 40,000 years ago (ka), when modern humans colonized Eurasia replacing existing hominin populations such as the Neandertals, and a variety of “transitional” and/or early Upper Palaeolithic cultures emerged. Here, we present shell ornaments from the Uluzzian site of Grotta del Cavallo in Italy, southern Europe. Our results show evidence of a local production of shell beads for ornamental purposes as well as a trend toward higher homogeneity in tusk bead shape and size over time. The temporal interval of the layers of interest (45–40 ka) makes Cavallo the earliest known shell ornament making context in Europe