Arrhythmias and hemodialysis: role of potassium and new diagnostic tools.

Cardiovascular diseases represent the main causes of death in patients affected by renal failure, and arrhythmias are frequently observed in patients undergoing hemodialysis. Dialytic treatment per se can be considered as an arrhythmogenic stimulus; moreover, uraemic patients are characterized by a "pro-arrhythmic substrate" because of the high prevalence of ischaemic heart disease, left ventricular hypertrophy and autonomic neuropathy. One of the most important pathogenetic element involved in the onset of intra-dialytic arrhythmias is the alteration in electrolytes concentration, particularly calcium and potassium. It may be very useful to monitor the patient's cardiac activity during the whole hemodilaytic session. Nevertheless, the application of an extended intradialytic electrocardiographic monitoring is not simple because of several technical and structural impairments. We tried to overcome these difficulties using Whealthy, a wearable system consisting in a t-shirt composed of conductors and piezoresistive materials, integrated to form fibers and threads connected to tissutal sensors, electrodes, and connectors. ECG and pneumographic impedance signals are acquired by the electrodes in the tissue, and the data are registered by a small computer and transmitted via GPRS or Bluetooth

A new enhanced PSPICE implementation of the equivalent circuit model of SiPM detectors

The present work proposes an improved PSPICE implementation of the equivalent electrical model of silicon photomultipliers (SiPMs) to simulate and predict their transient re-sponse to avalanche trigger events. In particular, the developed model provides a detailed investigation of magnitude and timing of the read-out signals and can therefore be exploited to perform reliable circuit-level simulations. The modeling approach used is strictly related to the physics of each basic microcell constituting the SiPM device, and allows the avalanche timing as well as the photodiode current and voltage to be accurately simulated. Predictive capabilities of the proposed model are demonstrated by means of experimental measurements on a real detector. Versatility of the proposed model is also confirmed

Characterization of a 6×6-mm2 75-μm cell MPPC suitable for the Cherenkov Telescope Array project

This paper presents the latest characterization results of a novel Low Cross-Talk (LCT) large-area (6×6-mm2) Multi-Pixel Photon Counter (MPPC) detector manufactured by Hamamatsu, belonging to the recent LCT5 family and achieving a fill-factor enhancement and cross-talk reduction. In addition, the newly adopted resin coating is demonstrated to yield improved photon detection capabilities in the 290–350 nm spectral range, making the new LCT MPPC particularly suitable for emerging applications like Cherenkov Telescopes. For a 3×3-mm2 version of the new MPPC under test, a comparative analysis of the large pixel pitch (75-µm) detector versus the smaller pixel pitch (50-µm) detector is also undertaken. Furthermore, measurements of the 6×6-mm2 MPPC response versus the angle of incidence are provided for the characterized device

Italian recommendations on enzymatic debridement in burn surgery.

Abstract Introduction Nexobrid®, a bromelain-based type of enzymatic debridement, has become more prevalent in recent years. We present the recommendations on enzymatic debridement (Nexobrid®)'s role based on the practice knowledge of expert Italian users. Methods The Italian recommendations, endorsed by SIUST (Italian Society of Burn Surgery), on using enzymatic debridement to remove eschars for burn treatment were defined. The definition followed a process to evaluate the level of agreement (a measure of consensus) among selected experts, representing Italian burn centers, concerning defined clinical aspects of enzymatic debridement. The consensus involved a multi-phase process based on the Delphi method. Results The consensus panel included experts from Italy with a combined experience of 1068 burn patients treated with enzymatic debridement. At the end of round 3 of the Delphi method, the panel reached 100% consensus on 26 out of 27 statements. The panel achieved full, strong consensus (all respondents strongly agreed on the statement) on 24 out of 27 statements. Discussion The statements provided by the Italian consensus panel represent a "ready to use" set of recommendations for enzymatic debridement in burn surgery that both draw from and complete the existing scientific literature on the topic. These recommendations are specific to the Italian experience and are neither static nor definitive. As such, they will be updated periodically as further quality evidence becomes available

Arthrographis curvata and Rhodosporidium babjevae as New Potential Fungal Lipase Producers for Biotechnological Applications

n/

Temperature characterization of the CITIROC front-end chip of the ASTRI SST-2M Cherenkov camera

The Cherenkov Imaging Telescope Integrated Read Out Chip, CITIROC, is the front-end chip of the camera for the ASTRI SST-2M, one of the prototypes for the small sized telescopes of the Cherenkov Telescope Array, CTA. The telescope, operating in the energy range from a few TeV to beyond 300 TeV, is characterized by innovative technological solutions. The optical system is arranged in a dual-mirror configuration and the focal plane camera consists of a matrix of multi-pixel Silicon Photo-Multipliers. Among others, one of the most important project issue consists in the thermal characterization of the camera that, in the ASTRI SST-2M prototype, is thermo-controlled in a narrow temperature range. A set of at least nine similar telescopes will form the ASTRI mini-array proposed to be installed at the CTA southern site. In the cameras of the ASTRI mini-array telescopes the thermal control could be relaxed with a considerable gain in terms of power consumption, cost and simplicity. So, a study of the temperature dependence of the camera components is needed. The present work addresses this issue showing the results of the measurements carried out on CITIROC as a function of the temperature. We focused our investigation on the pedestal stability, linearity of the charge output signal, preamplifier gain and trigger uniformity in the temperature range 15-30°C. Our results show, for each of the above-mentioned measurable quantities, that temperature dependency is at the level of a few percent

Clinical validation of 13-Gene DNA methylation analysis from oral brushing: a non invasive sampling procedure for early detection of oral squamous cell carcinoma. A multicentric study

1. Introduction In a recent study our research group described a non-invasive sampling procedure based on DNA methylation analysis of a set of 13 genes with a high level of accuracy (sensitivity 96.6%, specificity 100%) in the detection of squamous cell carcinoma of the oral cavity (OSCC) [1]. The purpose of the present study was to test the diagnostic performance of this non invasive sampling procedure in an italian multicentric study. 2. Materials and Methods Oral brushing specimens were collected in ten different italian units of oral medicine. Each oral medicine unit collected blindly 10 brushing specimens from patients affected by OSCC and an equal number of age and sex-matched healthy controls. 13-gene DNA methylation analysis was performed and each sample was considered positive or negative in relation to a predefined cut-off value. 3. Results 181 out of 200 planned specimens were analyzed. DNA could not be amplified in 4 cases (2.2%). 86/93 (92.5%) specimens derived from OSCC patients were detected as positive and 70/84 (83.3%) specimens derived from healthy donors showed a negative score. 4. Conclusions Data from multicentric study confirmed a high level of sensitivity of our procedure whereas level of specificity is slightly lower if compared to our previous study. These data suggest that our procedure may be proposed as a first level diagnostic test with the aim to avoid a diagnostic delay in Oral Squamous Cell Carcinoma. Conflicts of Interest: As a possible conflict of interest, L. Morandi and D.B.G. submitted a patent (the applicant is the University of Bologna) in November 2016 to the National Institute of 398 Industrial Property; however, we believe that this is a natural step of translational research (bench-to-bedside) 399 and guarantee that the scientific results are true. The remaining authors declare that they have no competing 400 interest

ASTRI SST-2M camera electronics

ASTRI SST-2M is an Imaging Atmospheric Cherenkov Telescope (IACT) developed by the Italian National Institute of Astrophysics, INAF. It is the prototype of the ASTRI telescopes proposed to be installed at the southern site of the Cherenkov Telescope Array, CTA. The optical system of the ASTRI telescopes is based on a dual mirror configuration, an innovative solution for IACTs, and the focal plane of the camera is composed of silicon photo-multipliers (SiPM), a recently developed technology for light detection, that exhibit very fast response and an excellent single photoelectron resolution. The ASTRI camera electronics is specifically designed to directly interface the SiPM sensors, detecting the fast pulses produced by the Cherenkov flashes, managing the trigger generation, the digital conversion of the signals and the transmission of the data to an external camera server connected through a LAN. In this contribution we present the general architecture of the camera electronics developed for the ASTRI SST-2M prototype, with special emphasis to some innovative solutions

Construction and characterization of the detection modules for the Muon Portal Project

The Muon Portal Project is a joint initiative between research and industrial partners, aimed at the construction of a real size detector protoype (6×3×7 m3) for the inspection of containers by the muon scattering technique, devised to search for hidden high-Z fissile materials and provide a full 3D tomography of the interior of the container in a scanning time of the order of minutes. The muon tracking detector is based on a set of 48 detection modules (size 1 m × 3 m), each built with 100 extruded scintillator strips, so as to provide four X-Y detection planes, two placed above and two below the container to be inspected. Two wavelength shifting (WLS) fibres embedded in each strip convey the emitted photons to Silicon Photomultipliers (SiPM) which act as photosensors. After a research and development phase, which led to the choice and test of the individual components, the construction of the full size detector has already started. The paper describes the results of the mass characterization of the photosensors and the construction and test measurements of the first detection modules of the Project