Lo strano caso del killer Magnefredo: uomini e terre del monastero di Sant’Ambrogio in Valtellina nel secolo IX tra micro e macrostoria

ITALIANO: Questo intervento analizza il libro "The Lands of Saint Ambrose. Monks and Society in Early Medieval Milan" di Ross Balzaretti, con particolare attenzione al tema della condizione delle persone e dello sfruttamento della proprietà fondiaria a partire dal caso del “dossier” della Valtellina. / ENGLISH: This paper analyses the book The Lands of Saint Ambrose. Monks and Society in Early Medieval Milan by Ross Balzaretti, with a particular regard to the dependent peasantry and the exploitation of landed property starting from the case of the Valtellina “dossier”

Multi-Segmentation and Annotation of 3D Surface Meshes

The ShapeAnnotator is a graphical tool designed to assist an expert user in the task of annotating a surface mesh with concepts belonging to a domain of expertise. The user is first required to identify meaningful surface features; Each such feature can then be "labeled" with a concept, and the surface mesh, along with the features identified and their labels, can be saved

Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors

Tenatumomab is an anti-tenascin murine monoclonal antibody previously used in clinical trials for delivering radionuclides to tumors by both pre-targeting (biotinylated Tenatumomab within PAGRIT) and direct 131Iodine labeling approaches. Here we present the synthesis and in vitro characterization of three Tenatumomab conjugates to bifunctional chelating agents (NHS-DOTA, NCS-DOTA and NCS-DTPA). Results indicate ST8198AA1 (Tenatumomab-DOTAMA, derived by conjugation of NHS-DOTA), as the most promising candidate in terms of conjugation rate and yield, stability, antigen immunoreactivity and affinity. Labeling efficiency of the different chelators was investigated with a panel of cold metals indicating DOTAMA as the best chelator. Labeling of Tenatumomab-DOTAMA was then optimized with several metals and stability performed confirms suitability of this conjugate for further development. ST8198AA1 represents an improvement of the previous antibody forms because the labeling with radionuclides like 177Lu or 64Cu would allow theranostic applications in patients bearing tenascin expressing tumors

Molecular epidemiology of a hepatitis C virus epidemic in a haemodialysis unit: outbreak investigation and infection outcome

<p>Abstract</p> <p>Background</p> <p>HCV is a leading cause of liver chronic diseases all over the world. In developed countries the highest prevalence of infection is reported among intravenous drug users and haemodialysis (HD) patients. The present report is to identify the pathway of HCV transmission during an outbreak of HCV infection in a privately run haemodialysis (HD) unit in Italy in 2005.</p> <p>Methods</p> <p>Dynamics of the outbreak and infection clinical outcomes were defined through an ambi-directional cohort study. Molecular epidemiology techniques were used to define the relationships between the viral variants infecting the patients and confirm the outbreak. Risk analysis and auditing procedures were carried out to define the transmission pathway(s).</p> <p>Results</p> <p>Of the 50 patients treated in the HD unit 5 were already anti-HCV positive and 13 became positive during the study period (AR = 28.9%). Phylogenic analysis identified that, all the molecularly characterized incident cases (10 out of 13), were infected with the same viral variant of one of the prevalent cases. The multivariate analysis and the auditing procedure disclosed a single event of multi-dose vials heparin contamination as the cause of transmission of the infection in 11 out of the 13 incident cases; 2 additional incident cases occurred possibly as a result of inappropriate risk management.</p> <p>Discussion</p> <p>More than 30% of all HCV infections in developed countries results from poor application of standard precautions during percutaneous procedures. Comprehensive strategy which included: educational programmes, periodical auditing on standard precaution, use of single-dose vials whenever possible, prospective surveillance for blood-borne infections (including a system of prompt notification) and risk assessment/management dedicated staff are the cornerstone to contain and prevent outbreaks in HD</p> <p>Conclusions</p> <p>The outbreak described should serve as a reminder to HD providers that patients undergoing dialysis are at risk for HCV infection and that HCV may be easily transmitted whenever standard precautions are not strictly applied.</p

La fine dell'impero carolingio e i conflitti per il regno italico nei Gesta Berengarii

Il saggio analizza come la crisi dell’impero carolingio sia stata rappresentata nei Gesta Berengarii, un panegirico anonimo di inizio X secolo. Esso pone in risalto in particolare come l’autore del poema, alla pari di altri storici coevi, avesse scritto un testo non tanto con lo scopo di descrivere la realtà politica del tempo, quanto di modificarla con la sua opera, dando un senso ai cambiamenti avvenuti dopo la morte di Carlo III. In questa prospettiva egli riprese il tòpos retorico-politico del “monopolio dinastico carolingio” e reinventò in senso carolingio la genealogia di Berengario I: egli non sarebbe stato uno dei tanti reguli saliti al potere dopo l’888, ma l’ultimo, vero re e imperatore carolingio