The COBRAS/SAMBA CMB Project

COBRAS/SAMBA is a second generation satelitte dedicated to mapping at high resolution and sensitivity the anisotropies of the Cosmic Microwave Background (CMB). This mission is in the assessment study phase (A) at ESA, with a decision expected mid 1996, for a launch around 2003.Comment: PostScript, 4 pages, 4 figures in text, to appear in the Proceedings of the 1995 Moriond Meeting on ``Clustering in the Universe'

FIRBACK Source Counts and Cosmological Implications

FIRBACK is a one of the deepest surveys performed at 170 microns with ISOPHOT onboard ISO, and is aimed at the study of cosmic far infrared background sources. About 300 galaxies are detected in an area of four square degrees, and source counts present a strong slope of 2.2 on an integral "logN-logS" plot, which cannot be due to cosmological evolution if no K-correction is present. The resolved sources account for less than 10% of the Cosmic Infrared Background at 170 microns. In order to understand the nature of the sources contributing to the CIB, and to explain deep source counts at other wavelengths, we have developed a phenomenological model, which constrains in a simple way the luminosity function evolution with redshift, and fits all the existing deep source counts from the mid-infrared to the submillimetre range. Images, materials and papers available on the FIRBACK web: http://wwwfirback.ias.u-psud.fr wwwfirback.ias.u-psud.frComment: proceedings of "ISO Surveys of a Dusty Universe", eds. D. Lemke, M. Stickel, K. Wilke, Ringberg, 8-12 Nov 1999, to appear in Springer 'Lecture Notes of Physics'. 8 pages, 7 eps figures, .sty include

FIRBACK Source Counts and Cosmological Implications

FIRBACK is a one of the deepest surveys performed at 170 microns with ISOPHOT onboard ISO, and is aimed at the study of cosmic far infrared background sources. About 300 galaxies are detected in an area of four square degrees, and source counts present a strong slope of 2.2 on an integral "logN-logS" plot, which cannot be due to cosmological evolution if no K-correction is present. The resolved sources account for less than 10% of the Cosmic Infrared Background at 170 microns. In order to understand the nature of the sources contributing to the CIB, and to explain deep source counts at other wavelengths, we have developed a phenomenological model, which constrains in a simple way the luminosity function evolution with redshift, and fits all the existing deep source counts from the mid-infrared to the submillimetre range. Images, materials and papers available on the FIRBACK web: http://wwwfirback.ias.u-psud.fr wwwfirback.ias.u-psud.frComment: proceedings of "ISO Surveys of a Dusty Universe", eds. D. Lemke, M. Stickel, K. Wilke, Ringberg, 8-12 Nov 1999, to appear in Springer 'Lecture Notes of Physics'. 8 pages, 7 eps figures, .sty include

Impact of cerebral blood flow and amyloid load on SUVR bias

BACKGROUND: Despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially explained by changes in cerebral blood flow (CBF) and is likely to be also dependent on the extent of the underlying amyloid-β (Aβ) burden. This study aimed to compare SUVR with DVR and to evaluate the effects of underlying Aβ burden and CBF on bias in SUVR in mainly cognitively unimpaired participants. Participants were scanned according to a dual-time window protocol, with either [18F]flutemetamol (N = 90) or [18F]florbetaben (N = 31). The validated basisfunction-based implementation of the two-step simplified reference tissue model was used to derive DVR and R1 parametric images, and SUVR was calculated from 90 to 110 min post-injection, all with the cerebellar grey matter as reference tissue. First, linear regression and Bland-Altman analyses were used to compare (regional) SUVR with DVR. Then, generalized linear models were applied to evaluate whether (bias in) SUVR relative to DVR could be explained by R1 for the global cortical average (GCA), precuneus, posterior cingulate, and orbitofrontal region. RESULTS: Despite high correlations (GCA: R2 ≥ 0.85), large overestimation and proportional bias of SUVR relative to DVR was observed. Negative associations were observed between both SUVR or SUVRbias and R1, albeit non-significant. CONCLUSION: The present findings demonstrate that bias in SUVR relative to DVR is strongly related to underlying Aβ burden. Furthermore, in a cohort consisting mainly of cognitively unimpaired individuals, the effect of relative CBF on bias in SUVR appears limited. EudraCT Number: 2018-002277-22, registered on: 25-06-2018

Pushdown automata in statistical machine translation

This article describes the use of pushdown automata (PDA) in the context of statistical machine translation and alignment under a synchronous context-free grammar. We use PDAs to compactly represent the space of candidate translations generated by the grammar when applied to an input sentence. General-purpose PDA algorithms for replacement, composition, shortest path, and expansion are presented. We describe HiPDT, a hierarchical phrase-based decoder using the PDA representation and these algorithms. We contrast the complexity of this decoder with a decoder based on a finite state automata representation, showing that PDAs provide a more suitable framework to achieve exact decoding for larger synchronous context-free grammars and smaller language models. We assess this experimentally on a large-scale Chinese-to-English alignment and translation task. In translation, we propose a two-pass decoding strategy involving a weaker language model in the first-pass to address the results of PDA complexity analysis. We study in depth the experimental conditions and tradeoffs in which HiPDT can achieve state-of-the-art performance for large-scale SMT. </jats:p

Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: fundamentals of care for uveitis (focus) initiative

Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. Clinical Relevance: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. Methods: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic reviewof the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE,CINAHL,SCOPUS,BIOSIS, andWeb of Science). Publications included randomized controlled trials, prospective and retrospective studies with sufficient follow-up, case series with 15 cases or more, peer-reviewed articles, and hand-searched conference abstracts from key conferences. The proposed statements were circulated among 130 international uveitis experts for review.Atotal of 44 globally representativegroupmembersmet in late 2016 to refine these guidelines using a modified Delphi technique and assigned Oxford levels of evidence. Results: In total, 10 questions were addressed resulting in 21 evidence-based guidance statements covering the following topics: when to start noncorticosteroid immunomodulatory therapy, including both biologic and nonbiologic agents; what data to collect before treatment; when to modify or withdraw treatment; how to select agents based on individual efficacy and safety profiles; and evidence in specific uveitic conditions. Shared decision-making, communication among providers and safety monitoring also were addressed as part of the recommendations. Pharmacoeconomic considerations were not addressed. Conclusions: Consensus guidelines were developed based on published literature, expert opinion, and practical experience to bridge the gap between clinical needs and medical evidence to support the treatment of patients with noninfectious uveitis with noncorticosteroid immunomodulatory agents

Modelling the Pan-Spectral Energy Distribution of Starburst Galaxies: I. The role of ISM pressure & the Molecular Cloud Dissipation Timescale

In this paper, we combine the stellar spectral synthesis code STARBURST 99, the nebular modelling code MAPPINGS IIIq, a 1-D dynamical evolution model of \HII regions around massive clusters of young stars and a simplified model of synchrotron emissivity to produce purely theoretical self-consistent synthetic spectral energy distributions (SEDs) for (solar metallicity) starbursts lasting some $10^8$ years. These SEDs extend from the Lyman Limit to beyond 21 cm. We find that two ISM parameters control the form of the SED; the pressure in the diffuse phase of the ISM (or, equivalently, its density), and the molecular cloud dissipation timescale. We present detailed SED fits to Arp 220 and NGC 6240, and we give the predicted colors for starburst galaxies derived from our models for the IRAS and the Spitzer Space Observatory MIPS and IRAC instruments. Our models reproduce the spread in observed colors of starburst galaxies. Finally, we present absolute calibrations to convert observed fluxes into star formation rates in the UV (GALEX), at optical wavelengths (H$\alpha$), and in the IR (IRAS or the Spitzer Space Observatory). (Abstract Truncated)Comment: 56 pages, 16 figures, accepted by The Apstrophysical Journal For version with full, colour figures go to http://www.mso.anu.edu.au/~bgroves/starburst