Aspectos fitotécnicos e fitoquímicos de acessos de fáfia

The medicinal species fafia (Hebanthe eriantha), is a product of extractivism in the region of the Paraiba Valley, São Paulo state, Brazil, with endangered genetic variability. This study did an agronomical characterization and an analysis of active compounds of five accessions. This research is a partnership of UNESP-Botucatu Medicinal Plants Laboratory, Paraiba Valley Center (APTA) and CPQBA-UNICAMP Agrotechnological Division. A field experiment using completely random blocks with five accessions and seven replications was used. The stem and leaf wet/dry weights, root wet/dry weight, length of the longest stem, foliar area, foam index and pfaffic acid content samples were evaluated. Accession I1800 had root dry weight, stem and leaf dry weight, and foliar area greater than other accessions (176.16 g/plant, 7.301 kg/plant, 155.04 cm² ). Pfaffic acid content was similar to other accessions (0.640-0.366 %mm-1) Among all five accessions, there is a positive correlation among the foliar area and stem and leaf dry weight and between the foliar area and root dry weight.A espécie medicinal fáfia (Hebanthe eriantha), é um recurso extrativista da região do Vale do Paraíba, cuja variabilidade genética encontra-se ameaçada. Neste estudo realizou-se a caracterização agronômica e análise de princípio ativo de cinco acessos. Este estudo é uma parceria entre o Laboratório de Plantas Medicinais da UNESP-Botucatu, o Pólo Vale do Paraíba em Pindamonhangaba da Agência Paulista de Tecnologia dos Agronegócios (APTA) e a Divisão de Agrotecnologia do Centro Pluridisciplinar de Pesquisas Químicas Biológicas e Agrícolas (CPQBA) da UNICAMP. Foi instalado um ensaio experimental a campo em blocos casualizados com cinco acessos e sete repetições. Foram avaliadas a massa fresca e seca da parte aérea, a massa fresca e seca da raiz, o comprimento da maior haste, a área foliar, o índice de espuma e o teor de ácido fáfico das amostras. O acesso I1800 apresentou uma massa seca de raiz, massa seca da parte aérea e área foliar superior aos demais acessos (176,16 g/planta, 7,301 kg/planta, 155,04 cm² ). O teor de ácido fáfico não diferiu entre os acessos (0,640-0,366 %/mm) Existe uma correlação positiva entre área foliar e massa seca da parte aérea e entre área foliar e massa seca de raízes entre os cinco acessos.133138Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Agronomical and phytochemical aspects of fafia

A espécie medicinal fáfia (Hebanthe eriantha), é um recurso extrativista da região do Vale do Paraíba, cuja variabilidade genética encontra-se ameaçada. Neste estudo realizou-se a caracterização agronômica e análise de princípio ativo de cinco acessos. Este estudo é uma parceria entre o Laboratório de Plantas Medicinais da UNESP-Botucatu, o Pólo Vale do Paraíba em Pindamonhangaba da Agência Paulista de Tecnologia dos Agronegócios (APTA) e a Divisão de Agrotecnologia do Centro Pluridisciplinar de Pesquisas Químicas Biológicas e Agrícolas (CPQBA) da UNICAMP. Foi instalado um ensaio experimental a campo em blocos casualizados com cinco acessos e sete repetições. Foram avaliadas a massa fresca e seca da parte aérea, a massa fresca e seca da raiz, o comprimento da maior haste, a área foliar, o índice de espuma e o teor de ácido fáfico das amostras. O acesso I1800 apresentou uma massa seca de raiz, massa seca da parte aérea e área foliar superior aos demais acessos (176,16 g/planta, 7,301 kg/planta, 155,04 cm² ). O teor de ácido fáfico não diferiu entre os acessos (0,640-0,366 %/mm) Existe uma correlação positiva entre área foliar e massa seca da parte aérea e entre área foliar e massa seca de raízes entre os cinco acessos.The medicinal species fafia (Hebanthe eriantha), is a product of extractivism in the region of the Paraiba Valley, São Paulo state, Brazil, with endangered genetic variability. This study did an agronomical characterization and an analysis of active compounds of five accessions. This research is a partnership of UNESP-Botucatu Medicinal Plants Laboratory, Paraiba Valley Center (APTA) and CPQBA-UNICAMP Agrotechnological Division. A field experiment using completely random blocks with five accessions and seven replications was used. The stem and leaf wet/dry weights, root wet/dry weight, length of the longest stem, foliar area, foam index and pfaffic acid content samples were evaluated. Accession I1800 had root dry weight, stem and leaf dry weight, and foliar area greater than other accessions (176.16 g/plant, 7.301 kg/plant, 155.04 cm² ). Pfaffic acid content was similar to other accessions (0.640-0.366 %mm-1) Among all five accessions, there is a positive correlation among the foliar area and stem and leaf dry weight and between the foliar area and root dry weight.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Renin angiotensin system blockage associates with insertion/deletion polymorphism of angiotensin-converting enzyme in patients with hypertensive emergency

Hypertensive crisis (HC) stands out as a form of acute elevation of blood pressure (BP). It can manifest itself as hypertensive emergency (HE) or hypertensive urgency (HU), which is usually accompanied with levels of diastolic BP ≥120 mmHg. Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism may influence manifestations of HC. Thus, this study evaluated the influence of ACE I/D polymorphism in individuals with HC. A total of 187 patients admitted with HC (HU [n=69] and HE [n=118]) and 75 normotensive individuals were included in the study. Peripheral blood was drawn for a biochemical and genetic analysis of the ACE I/D polymorphism by Polymerase Chain Reaction. HC group showed higher systolic BP, body mass index (BMI), glycemia, creatinine, and lower high-density lipoprotein (HDL) cholesterol compared with normotensive individuals. The use of renin-angiotensin system (RAS) blockers was more frequent in the HU group than in the HE group (p=0.020). The II genotype was more predominant in normotensive and HU individuals than among HE individuals (18.7%, 11.6%, and 2.5%, respectively; p=0.004). Higher BMI and glycemia were associated with HC in the logistic regression model. ACE II genotype (odds ratio [OR] 0.14; 95% confidence interval [CI] 0.04-0.51) and HDL cholesterol were protective for the development of HE. ACE II genotype was present in the HU group, compared with the HE group (OR 0.18; 95% CI 0.04-0.88). This study shows an association between the low prevalence of ACE I/D polymorphism II genotype and a greater occurrence of HE in Brazilian individuals. The lower blockage of RAS, which was detected in the HE group, may interact with the low frequency of II genotype, conferring an increased risk for HE

Ferrovias, doenças e medicina tropical no Brasil da Primeira República Railroads, disease, and tropical medicine in Brazil under the First Republic

Aborda o impacto da malária no âmbito da modernização republicana, basicamente nas ferrovias, que asssumiram então o papel de integrar o território e operar a expansão simbólica e material da nação brasileira. Os cientistas destacados para debelar os surtos epidêmicos não se limitaram a realizar as campanhas. Fizeram observações sobre aspectos da doença, inclusive suas relações com hospedeiros e ambientes, contribuindo com novos conhecimentos e com a institucionalização, no Brasil, de novo campo que então se estabelecia nas potências coloniais européias: a medicina tropical. O artigo articula essas inovações - especialmente a teoria da infecção domiciliária - com as campanhas em prol de ferrovias e com estágio subseqüente no enfrentamento da malária no Brasil, nos anos 1920.<br>The article explores the impact of malaria on infrastructure works - above all, railroads - under the republican drive towards modernization. Railways helped tie the territory together and foster the symbolic and material expansion of the Brazilian nation. The scientists entrusted with vanquishing such epidemic outbreaks did not just conduct campaigns; they also undertook painstaking observations of aspects of the disease, including its relations to hosts and the environment, thus contributing to the production of new knowledge of malaria and to the institutionalization of a new field in Brazil, then taking root in Europe's colonies: "tropical medicine." The article shows the ties between these innovations (especially the theory of domiciliary infection) and the sanitary campaigns that helped the railways, which in the 1920s were followed by a new phase in Brazil's anti-malaria efforts

First Report of the Hyper-IgM Syndrome Registry of the Latin American Society for Immunodeficiencies: Novel Mutations, Unique Infections, and Outcomes

Hyper-IgM (HIGM) syndrome is a heterogeneous group of disorders characterized by normal or elevated serum IgM levels associated with absent or decreased IgG, IgA and IgE. Here we summarize data from the HIGM syndrome Registry of the Latin American Society for Immunodeficiencies (LASID). of the 58 patients from 51 families reported to the registry with the clinical phenotype of HIGM syndrome, molecular defects were identified in 37 patients thus far. We retrospectively analyzed the clinical, immunological and molecular data from these 37 patients. CD40 ligand (CD40L) deficiency was found in 35 patients from 25 families and activation-induced cytidine deaminase (AID) deficiency in 2 unrelated patients. Five previously unreported mutations were identified in the CD40L gene (CD40LG). Respiratory tract infections, mainly pneumonia, were the most frequent clinical manifestation. Previously undescribed fungal and opportunistic infections were observed in CD40L-deficient patients but not in the two patients with AID deficiency. These include the first cases of pneumonia caused by Mycoplasma pneumoniae, Serratia marcescens or Aspergillus sp. and diarrhea caused by Microsporidium sp. or Isospora belli. Except for four CD40L-deficient patients who died from complications of presumptive central nervous system infections or sepsis, all patients reported in this study are alive. Four CD40L-deficient patients underwent successful bone marrow transplantation. This report characterizes the clinical and genetic spectrum of HIGM syndrome in Latin America and expands the understanding of the genotype and phenotype of this syndrome in tropical areas.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Jeffrey Modell FoundationLatin American Advisory Board on Primary Immunodeficiencies initiativeUniv São Paulo, Inst Biomed Sci, Dept Immunol, BR-05508000 São Paulo, BrazilCtr Invest & Estudios, Dept Biomed Mol, Mexico City, DF, MexicoDr Ricardo Gutierrez Childrens Hosp, Buenos Aires, DF, ArgentinaHosp Nacl Ninos Dr Carlos Saenz Herrera, San Jose, Costa RicaPediat Allergy & Immunol Clin, Caxias Do Sul, RS, BrazilAlbert Sabin Hosp, Fortaleza, Ceara, BrazilHosp Base Dist Fed, Brasilia, DF, BrazilIntegrated Ctr Pediat Specialties, Curitiba, PR, BrazilHosp Ninos VJ Vilela, Rosario, ArgentinaHosp Ninos Luis Calvo Mackenna, Santiago, ChileUniv Fed Parana, Dept Pediat, BR-80060000 Curitiba, Parana, BrazilUniv Estadual Campinas, Sch Med, Dept Pediat, Campinas, SP, BrazilConceicao Childrens Hosp, Dept Pediat, Div Allergy & Immunol, Porto Alegre, RS, BrazilChildrens Hosp Lucidio Portela, Teresina, PI, BrazilPontificia Univ Catolica Chile, Div Pediat, Santiago, ChileUniv Estadual Campinas, Sch Med, Dept Med, Campinas, SP, BrazilUniv São Paulo, Ribeirao Preto Med Sch, BR-14049 Ribeirao Preto, SP, BrazilHosp Nacl Edgardo Rebagliati Martins Alergia & In, Lima, PeruUniv Fed Rio de Janeiro, Sch Med, Dept Pediat, Rio de Janeiro, BrazilInst Nacl Pediat, Unidad Invest Inmunodeficiencias, Mexico City, DF, MexicoIMSS, Unidad Med Alta Especialidad 25, Monterrey, Nuevo Leon, MexicoClin Montefiori, Unidad Inmunol, Lima, PeruUNAL, Univ Hosp, Monterrey, Nuevo Leon, MexicoFac Med ABC, Santo Andre, SP, BrazilChildrens Hosp, Dept Pediat, New Orleans, LA USAHop Necker Enfants Malad, INSERM, Unite U768, Paris, FranceUniv Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USASeattle Childrens Res Inst, Seattle, WA USAUniversidade Federal de São Paulo, Dept Pediat, Div Allergy Immunol & Rheumatol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, Div Allergy Immunol & Rheumatol, São Paulo, BrazilFAPESP: 2012/50515-4FAPESP: 2006/57643-7FAPESP: 2012/51745-3Web of Scienc