DIPLOMADO DE PROFUNDIZACION CISCO PRUEBA DE HABILIDADES PRÁCTICAS CCNP

La seguridad en redes es un tema complejo y en progresivo de TI. Cisco Systems como uno de los principales proveedores de dispositivos de seguridad en redes de comunicación brinda un gran respaldo en esta tecnología en la industria. Este documento plasma un ejemplo de cómo estructurar y configurar la seguridad redes conmutadas, está enfocado en el uso de enrutadores Cisco IOS como protección de redes y beneficiándose de sus características adelantadas como enrutador perimetral, firewall, como sistema contra intrusos o como punto de conexión VPN de sitio a sitio. Por otra parte, contiene la implementación los dispositivos electrónicos y servicios de Cisco adecuados necesarios en la estructuración de redes flexibles y seguras. Mientras envuelve el tema de seguridad Cisco Certified Network Professional (CCNP), también muestra la utilización de un dispositivo de seguridad adaptable (ASA) de Cisco para VPN de acceso remoto con cliente. Los comandos y modelos de configuración que se detallan en este libro están basados en las versiones 15 de Cisco IOS y Cisco IOU L2.Network security is a complex and progressive IT issue. Cisco Systems as one of the main providers of security devices in communication networks provides great support in this technology in the industry. This document shows an example of how to structure and configure switched network security, it is focused on the use of Cisco IOS routers as network protection and taking advantage of its advanced features as a perimeter router, firewall, as a system against intruders or as a VPN connection point. from site to site. On the other hand, it contains the implementation of the appropriate Cisco electronic devices and services necessary in the structuring of flexible and secure networks. While it wraps up the topic of Cisco Certified Network Professional (CCNP) security, it also shows the use of a Cisco Adaptive Security Appliance (ASA) for client remote access VPN. The commands and configuration models detailed in this book are based on Cisco IOS Releases 15 and Cisco IOU L2

Data Mining Techniques for Rainfall Regionalization in Parana State

The prevalence of agro-meteorological data for specific regions serve as parameters for agricultural and related climate studies. This study aims to regionalize the rainfall in the State of Paraná (Southern Brazil) through data mining techniques with ECMWF (European Centre for Medium Range Weather Forecasts) data from 1989 to 2013. The algorithms k-means and Simple EM (Expectation Maximization) for clustering were applied in Weka software, version 3.6. The quality of the clustering was determined with the J48 classification algorithm applied using training set. The decision tree presents similarity indexes and errors measures to determine the best number of cluster for this case. As results 6 regions of homogeneous rainfall in the state of Paraná were presented

GENCODE: reference annotation for the human and mouse genomes in 2023.

GENCODE produces high quality gene and transcript annotation for the human and mouse genomes. All GENCODE annotation is supported by experimental data and serves as a reference for genome biology and clinical genomics. The GENCODE consortium generates targeted experimental data, develops bioinformatic tools and carries out analyses that, along with externally produced data and methods, support the identification and annotation of transcript structures and the determination of their function. Here, we present an update on the annotation of human and mouse genes, including developments in the tools, data, analyses and major collaborations which underpin this progress. For example, we report the creation of a set of non-canonical ORFs identified in GENCODE transcripts, the LRGASP collaboration to assess the use of long transcriptomic data to build transcript models, the progress in collaborations with RefSeq and UniProt to increase convergence in the annotation of human and mouse protein-coding genes, the propagation of GENCODE across the human pan-genome and the development of new tools to support annotation of regulatory features by GENCODE. Our annotation is accessible via Ensembl, the UCSC Genome Browser and https://www.gencodegenes.org

Serotonin Reduction in Post-acute Sequelae of Viral Infection

Post-acute sequelae of COVID-19 (PASC, Long COVID ) pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated to explain the etiology of PASC, including viral persistence, chronic inflammation, hypercoagulability, and autonomic dysfunction. Here, we propose a mechanism that links all four hypotheses in a single pathway and provides actionable insights for therapeutic interventions. We find that PASC are associated with serotonin reduction. Viral infection and type I interferon-driven inflammation reduce serotonin through three mechanisms: diminished intestinal absorption of the serotonin precursor tryptophan; platelet hyperactivation and thrombocytopenia, which impacts serotonin storage; and enhanced MAO-mediated serotonin turnover. Peripheral serotonin reduction, in turn, impedes the activity of the vagus nerve and thereby impairs hippocampal responses and memory. These findings provide a possible explanation for neurocognitive symptoms associated with viral persistence in Long COVID, which may extend to other post-viral syndromes

The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries

DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt

Virtual reality-based conflict resolution: The impact of immersive 360° video on changing view points and moral judgment in the context of violent intergroup conflict

Publisher Copyright: © The Author(s) 2021.We present an experimental study conducted in the context of the Israeli–Palestinian conflict that examined the effect of immersive 360° video on inducing a more critical perception of the ingroup’s actions in the conflict. An immersive experience of a simulated conflict scenario filmed from the outgroup’s point of view led to the judgment of the ingroup actors’ behavior as less moral and less justified compared to watching the same scenario as a two-dimensional video. This effect was not mediated through increased outgroup perspective-taking and empathy but through higher levels of hostile emotions toward the ingroup actors, which in turn were influenced by an increased sense of presence and engagement in the immersive experience. These findings provide initial evidence for the still widely unexplored potential of virtual reality as a new method for conflict resolution.Peer reviewe

Plant metabolism and defence strategies in the flowering stage : Time-dependent responses of leaves and flowers under attack

Plants developing into the flowering stage undergo major physiological changes. Because flowers are reproductive tissues and resource sinks, strategies to defend them may differ from those for leaves. Thus, this study investigates the defences of flowering plants by assessing processes that sustain resistance (constitutive and induced) and tolerance to attack. We exposed the annual plant Brassica nigra to three distinct floral attackers (caterpillar, aphid and bacterial pathogen) and measured whole-plant responses at 4, 8 and 12 days after the attack. We simultaneously analysed profiles of primary and secondary metabolites in leaves and inflorescences and measured dry biomass of roots, leaves and inflorescences as proxies of resource allocation and regrowth. Regardless of treatments, inflorescences contained 1.2 to 4 times higher concentrations of primary metabolites than leaves, and up to 7 times higher concentrations of glucosinolates, which highlights the plant's high investment of resources into inflorescences. No induction of glucosinolates was detected in inflorescences, but the attack transiently affected the total concentration of soluble sugars in both leaves and inflorescences. We conclude that B. nigra evolved high constitutive rather than inducible resistance to protect their flowers; plants additionally compensated for damage by attackers via the regrowth of reproductive parts. This strategy may be typical of annual plants

Introducción A Los Métodos Computacionales-CI171-201802

Curso de especialidad en la carrera de ingeniería civil de carácter teórico-práctico dirigido a los estudiantes del 6to ciclo que busca desarrollar la competencia general Manejo de la Información y la competencia específica J de ABET:Conoce de temas contemporáneos.En la aplicación de la carrera de Ingeniería Civil muchas veces nos encontramos que no hay un software especializado para un problema en particular que se quiere resolver es por este motivo que el curso brinda al alumno las herramientas necesarias como programación métodos numéricos y uso del Matlab de tal modo que esté en la capacidad de aplicar y sustentar claramente métodos actuales de resolución numérica y programación para hallar la solución del problema