Prolonged Neuromuscular Blockade Following Succinylcholine Administration to a Patient with a Reduced Butyrylcholinesterase Activity

This case is about a 48-year-old woman known with a reduced butyrylcholinesterase activity, who developed prolonged neuromuscular blockade following the unintentional administration of succinylcholine. We took the opportunity to monitor the development of neuromuscular function during this period and blood samples were taken for molecular genetic analysis and for quantitative and qualitative analysis since not all causative mutations are functionally characterized. Reduced butyrylcholinesterase activity is discussed in many aspects. Clinical considerations are suggested concerning genetic counselling

Deep Thermal Infrared Imaging of HR 8799 bcde: New Atmospheric Constraints and Limits on a Fifth Planet

We present new $L^\prime$ (3.8 $\mu m$) and Br-$\alpha$ (4.05 $\mu m$) data and reprocessed archival $L^\prime$ data for the young, planet-hosting star HR 8799 obtained with Keck/NIRC2, VLT/NaCo and Subaru/IRCS. We detect all four HR 8799 planets in each dataset at a moderate to high signal-to-noise (SNR $\gtrsim$ 6-15). We fail to identify a fifth planet, "HR 8799 f", at $r$ $<$ 15 $AU$ at a 5-$\sigma$ confidence level: one suggestive, marginally significant residual at 0.2" is most likely a PSF artifact. Assuming companion ages of 30 $Myr$ and the Baraffe (Spiegel \& Burrows) planet cooling models, we rule out an HR 8799 f with mass of 5 $M_{J}$ (7 $M_{J}$), 7 $M_{J}$ (10 $M_{J}$), and 12 $M_{J}$ (13 $M_{J}$) at $r_{proj}$ $\sim$ 12 $AU$, 9 $AU$, and 5 $AU$, respectively. All four HR 8799 planets have red early T dwarf-like $L^\prime$ - [4.05] colors, suggesting that their SEDs peak in between the $L^\prime$ and $M^\prime$ broadband filters. We find no statistically significant difference in HR 8799 cde's colors. Atmosphere models assuming thick, patchy clouds appear to better match HR 8799 bcde's photometry than models assuming a uniform cloud layer. While non-equilibrium carbon chemistry is required to explain HR 8799 bc's photometry/spectra, evidence for it from HR 8799 de's photometry is weaker. Future, deep IR spectroscopy/spectrophotometry with the Gemini Planet Imager, SCExAO/CHARIS, and other facilities may clarify whether the planets are chemically similar or heterogeneous.Comment: 18 pages, 6 Tables, and 9 Figures. Fig. 1a is the key figure. Accepted for publication in Ap

The measurement of ancestral roots with genealogical data

This study presents a new method to measure the depth of ancestral roots in a population. This method sheds light on the migratory movements which led to present-day population distribution across space. The method was applied to a dataset of 5,100 ascending genealogies from seventeen regions of the province of Quebec (Canada). Dates of marriage of the earliest ancestors married in the same region as their descendants were used to measure the age of individual ancestral roots. The average regional ages vary between 16 and 157 years, while some individual roots reach as far back as 300 years in the same region. The proposed method can be useful for assessing how deeply rooted a contemporary population is at a local, regional or other geographical level

Cut elimination in multifocused linear logic

We study cut elimination for a multifocused variant of full linear logic in the sequent calculus. The multifocused normal form of proofs yields problems that do not appear in a standard focused system, related to the constraints in grouping rule instances in focusing phases. We show that cut elimination can be performed in a sensible way even though the proof requires some specific lemmas to deal with multifocusing phases, and discuss the difficulties arising with cut elimination when considering normal forms of proofs in linear logic.Comment: In Proceedings LINEARITY 2014, arXiv:1502.0441

A Combined Very Large Telescope and Gemini Study of the Atmosphere of the Directly Imaged Planet, Beta Pictoris b

We analyze new/archival VLT/NaCo and Gemini/NICI high-contrast imaging of the young, self-luminous planet Beta Pictoris b in seven near-to-mid IR photometric filters, using advanced image processing methods to achieve high signal-to-noise, high precision measurements. While Beta Pic b's near-IR colors mimic those of a standard, cloudy early-to-mid L dwarf, it is overluminous in the mid-infrared compared to the field L/T dwarf sequence. Few substellar/planet-mass objects-i.e., And b and 1RXJ 1609B-match Beta Pic b's JHKsL photometry and its 3.1 micron and 5 micron photometry are particularly difficult to reproduce. Atmosphere models adopting cloud prescriptions and large (approx. 60 micron)dust grains fail to reproduce the Beta Pic b spectrum. However, models incorporating thick clouds similar to those found forHR8799 bcde, but also with small (a fewmicrons) modal particle sizes, yield fits consistent with the data within the uncertainties. Assuming solar abundance models, thick clouds, and small dust particles (a = 4 micron), we derive atmosphere parameters of log(g) = 3.8 +/- 0.2 and Teff = 1575-1650 K, an inferred mass of 7+4 3 MJ, and a luminosity of log(L/L) approx. 3.80 +/- 0.02. The best-estimated planet radius, is approx. equal to 1.65 +/- 0.06 RJ, is near the upper end of allowable planet radii for hot-start models given the host star's age and likely reflects challenges constructing accurate atmospheric models. Alternatively, these radii are comfortably consistent with hot-start model predictions if Beta Pic b is younger than is approx. equal to 7 Myr, consistent with a late formation well after its host star's birth approx. 12+8 4 Myr ago

Noncanonical splicing junctions between exons and transposable elements represent a source of immunogenic recurrent neo-antigens in patients with lung cancer

Although most characterized tumor antigens are encoded by canonical transcripts (such as differentiation or tumor-testis antigens) or mutations (both driver and passenger mutations), recent results have shown that noncanonical transcripts including long noncoding RNAs and transposable elements (TEs) can also encode tumor-specific neo-antigens. Here, we investigate the presentation and immunogenicity of tumor antigens derived from noncanonical mRNA splicing events between coding exons and TEs. Comparing human non-small cell lung cancer (NSCLC) and diverse healthy tissues, we identified a subset of splicing junctions that is both tumor specific and shared across patients. We used HLA-I peptidomics to identify peptides encoded by tumor-specific junctions in primary NSCLC samples and lung tumor cell lines. Recurrent junction-encoded peptides were immunogenic in vitro, and CD8+ T cells specific for junction-encoded epitopes were present in tumors and tumor-draining lymph nodes from patients with NSCLC. We conclude that noncanonical splicing junctions between exons and TEs represent a source of recurrent, immunogenic tumor-specific antigens in patients with NSCLC

The Critical, Strategic Importance of Adaptive Optics-Assisted Ground-Based Telescopes for the Success of Future NASA Exoplanet Direct Imaging Missions

Ground-based telescopes coupled with adaptive optics (AO) have been playing a leading role in exoplanet direct imaging science and technological development for the past two decades and will continue to have an indispensable role for the next decade and beyond. Over the next decade, extreme AO systems on 8-10m telescopes will 1) mitigate risk for WFIRST-CGI by identifying numerous planets the mission can spectrally characterize, 2) validate performance requirements and motivate improvements to atmosphere models needed to unambiguously characterize solar system-analogues from space, and 3) mature novel technological innovations useful for space. Extremely Large Telescopes can deliver the first thermal infrared (10 $\mu m$) images of rocky planets around Sun-like stars and identify biomarkers. These data provide a future NASA direct imaging flagship mission (i.e. HabEx, LUVOIR) with numerous exo-Earth candidates and critical ancillary information to help clarify whether these planets are habitable.Comment: 5 pages, 3 figures; Astro2020 Decadal Survey submission; argues for strategic NASA support of ground-based exoplanet direct imaging science programs and tech development. arXiv admin note: substantial text overlap with arXiv:1803.0545

Quantifying the interplay between environmental and social effects on aggregated-fish dynamics

Demonstrating and quantifying the respective roles of social interactions and external stimuli governing fish dynamics is key to understanding fish spatial distribution. If seminal studies have contributed to our understanding of fish spatial organization in schools, little experimental information is available on fish in their natural environment, where aggregations often occur in the presence of spatial heterogeneities. Here, we applied novel modeling approaches coupled to accurate acoustic tracking for studying the dynamics of a group of gregarious fish in a heterogeneous environment. To this purpose, we acoustically tracked with submeter resolution the positions of twelve small pelagic fish (Selar crumenophthalmus) in the presence of an anchored floating object, constituting a point of attraction for several fish species. We constructed a field-based model for aggregated-fish dynamics, deriving effective interactions for both social and external stimuli from experiments. We tuned the model parameters that best fit the experimental data and quantified the importance of social interactions in the aggregation, providing an explanation for the spatial structure of fish aggregations found around floating objects. Our results can be generalized to other gregarious species and contexts as long as it is possible to observe the fine-scale movements of a subset of individuals.Comment: 10 pages, 5 figures and 4 supplementary figure