Análisis y diseño de la solución web del sistema de información administrativo de subsidios otorga EsSalud

Publicación a texto completo no autorizada por el autorLos subsidios por prestaciones económicas otorgadas por Essalud a los asegurados son procesos que actualmente se desarrollan manualmente. La presente tesina tiene como objetivo ayuda en el proceso de análisis y diseño de un sistema administrativo que apoye en las actividades que se desarrollan, sistematizándolas de manera que el otorgamiento de subsidios por incapacidad temporal, maternidad, lactancia y sepelio se realicen de manera óptima a través de la aplicación de la metodología de RUP en el proceso de elaboración del mismo.Trabajo de suficiencia profesiona

miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity

Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In vivo inhibition of miR-132 in mice prevented ocular dominance plasticity in identified neurons following monocular deprivation and affected the maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits.National Eye Institute (Ruth L. Kirschstein Postdoctoral Fellowship 1F32EY020066-01)Simons Foundation (Postdoctoral Fellowship)National Institutes of Health (U.S.) (EY017098)National Institutes of Health (U.S.) (EY007023

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

Lawson criterion for ignition exceeded in an inertial fusion experiment

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion

Precariedad, exclusión social y modelo de sociedad: lógicas y efectos subjetivos del sufrimiento social contemporáneo (IV). Innovación docente en Filosofía

El PIMCD “Precariedad, exclusión social y modelo de sociedad: lógicas y efectos subjetivos del sufrimiento social contemporáneo (IV). Innovación docente en Filosofía” constituye la cuarta edición de un PIMCD que ha recibido financiación en las últimas convocatorias de PIMCD UCM, de los que se han derivado actividades de formación para estudiantes de Grado, Máster y Doctorado y al menos 3 publicaciones colectivas publicadas por Ediciones Complutense, Siglo XXI y Palgrave McMillan

Emerging Marine Biotoxins in Seafood from European Coasts: Incidence and Analytical Challenges

The presence of emerging contaminants in food and the sources of the contamination are relevant issues in food safety. The impact of climate change on these contaminations is a topic widely debated; however, the consequences of climate change for the food system is not as deeply studied as other human and animal health and welfare issues. Projections of climate change in Europe have been evaluated through the EU Commission, and the impact on the marine environment is considered a priority issue. Marine biotoxins are produced by toxic microalgae and are natural contaminants of the marine environment. They are considered to be an important contaminant that needs to be evaluated. Their source is affected by oceanographic and environmental conditions; water temperature, sunlight, salinity, competing microorganisms, nutrients, and wind and current directions affect the growth and proliferation of microalgae. Although climate change should not be the only reason for this increase and other factors such as eutrophication, tourism, fishery activities, etc. could be considered, the influence of climate change has been observed through increased growth of dinoflagellates in areas where they have not been previously detected. An example of this is the recent emergence of ciguatera fish poisoning toxins, typically found in tropical or subtropical areas from the Pacific and Caribbean and in certain areas of the Atlantic Sea such as the Canary Islands (Spain) and Madeira (Portugal). In addition, the recent findings of the presence of tetrodotoxins, typically found in certain areas of the Pacific, are emerging in the EU and contaminating not only the fish species where these toxins had been found before but also bivalve mollusks. The emergence of these marine biotoxins in the EU is a reason for concern in the EU, and for this reason, the risk evaluation and characterization of these toxins are considered a priority for the European Food Safety Authorities (EFSA), which also emphasize the search for occurrence data using reliable and efficient analytical methods

State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels

Large-conductance voltage- and calcium-dependent potassium channels (BK, “Big K+”) are important controllers of cell excitability. In the BK channel, a large C-terminal intracellular region containing a “gating-ring” structure has been proposed to transduce Ca2+ binding into channel opening. Using patch-clamp fluorometry, we have investigated the calcium and voltage dependence of conformational changes of the gating-ring region of BK channels, while simultaneously monitoring channel conductance. Fluorescence resonance energy transfer (FRET) between fluorescent protein inserts indicates that Ca2+ binding produces structural changes of the gating ring that are much larger than those predicted by current X-ray crystal structures of isolated gating rings

Réponse IgG spécifique à la salive d’Aedes aegypti dans une population urbaine bolivienne : vers un nouveau biomarqueur d’exposition aux piqûres du vecteur de la dengue ?

International audienceLa morbidité/mortalité des infections transmises par des vecteurs arthropodes (arboviroses, paludisme, trypanosomes, leishmaniose) est directement liée à l'exposition de l'homme à la piqûre du vecteur. L'objectif principal du projet EPIVECT (EPidémiologie des VECTeurs) est d'évaluer, chez les individus exposés, les réponses anticorps (Ac) spécifiques aux protéines salivaires d'arthropodes dans le but d'identifier un nouveau marqueur d'exposition à la piqûre et par conséquent un nouvel indicateur d'exposition aux risques d'in­fection (1-3). Les résultats présentés ici concernent l'évaluation de l'exposition à Aedes aegypti, vecteur de dengue en Bolivie, et s'ins­crivent dans le programme EpiDengue sur les conditions d'émergence de la dengue dans les environnements en mutation. Dans le cadre d'une étude multi-disciplinaire menée dans la ville de Santa Cruz de la Sierra (Bolivie), la réponse IgG spécifique aux extraits de glandes salivaires d' Aedes aegypti a été évaluée par ELISA chez une population (n = 1 049-2 à 70 ans) exposée au risque de dengue. Les résul­tats immunologiques ont été comparés en fonction des données entomologiques de référence évaluant indirectement le degré d'exposi­tion des populations aux piqûres d'Ae. aegypti (nombre de larves t nymphes / habitant et nombre de gîtes/habitant). La réponse IgG anti­salive décroît significativement en fonction de l'âge des individus et est la plus élevée chez les enfants < 14 ans. En fonction des groupes entomologiques définis, le niveau des IgG spécifiques varie significativement en fonction du degré d'exposition au vecteur et apparaît le plus élevée dans le groupe de forte densité d'exposition comparativement aux autres groupes. L'analyse statistique des résultats obtenus (analyse bivariée et modèle de régression logistique) confirme ces résultats. En effet, le niveau de réponse IgG anti-salive est fortement corrélé à l'âge et la réponse IgG est également significativement corrélée au niveau de densité d'Aedes et ceci de manière indépendante de l'âge ou du sexe. Ces premiers résultats montrent l'association positive et significative entre le niveau de réponse Ac IgG anti-salive d'Ae. aegypti chez des individus exposés et le degré potentiel d'exposition au vecteur Aedes. Cette première approche suggère que l'éva­luation des réponses Ac aux protéines salivaires d'Aedes pourrait être un nouvel outil immuno-épidémiologique, biomarqueur de l'exposition aux piqûres de ce vecteur et ainsi un indicateur potentiel des risques de transmission de Dengue