Self Enforcing Voting in International Organizations

Some international organizations are governed by unanimity rule, some others by a majority system. Still others have moved from one system to the other over time. The existing voting models, which generally assume that decisions made by voting are perfectly enforceable, have a difficult time explaining the observed variation in governance mode, and in particular the widespread occurrence of the unanimity system. We present a model whose main departure from standard voting models is that there is no external enforcement mechanism: each country is sovereign and cannot be forced to follow the collective decision, or in other words, the voting system must be self-enforcing. The model yields unanimity as the optimal system for a wide range of parameters, and delivers rich predictions on the variation in the mode of governance, both across organizations and over time.

To be or not to be, that is the question: The Marsala meteorite (Italy, 1834) and the role of the doubtful meteorites in the history of meteoritics

AbstractThis work focuses on the historical and scientific investigation of a presumed meteorite fall that occurred in the Sicilian township of Marsala in 1834. Preliminary studies have classified this phenomenon as a "doubtful meteorite." This term describes, according to the Nomenclature Committee of the Meteoritical Society, an object for which there was significant uncertainty over whether it was a real meteorite or, in some cases, whether it ever existed. Thanks to the analysis of untapped sources, the first objective of this work is to clarify the nature of the event. Subsequently, the results of the minero‐chemical analyses that were performed, in 1835, on two fragments recovered after the event are discussed for the first time. This work then shows the collecting history of one of the presumed meteorite specimens. Based on the results presented here, this work highlights the role of doubtful meteorites as a fundamental resource for the history of meteoritics and meteorite collecting as well as for studying the processes that have led to the scientific study of meteorites

4 slides e 1 buio-in-sala. Per un nuovo quadro della business continuity negli studi delle arti acustiche

The author, through a highly personal and rich in references path, develops an original critical perspective towards the different manifestations of the digital sound and its implications and social connotations. Are analyzed, among others, the significant factors – from the point of view of management – of success in terms of business continuity plan, the concept of authorship, the revolution of the concept of ‘narrative’ proper to the means, the idea of error, the relationship between academia and ‘self-study’, the relations with the ‘audiovisual’, the report auditorium/internet

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner.

Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma. Herein we demonstrated that the TKI axitinib induces DNA damage response (DDR) characterized by γ-H2AX phosphorylation and Chk1 kinase activation leading to G2/M cell cycle arrest and mitotic catastrophe in U87, T98 and U251 glioma cell lines. Moreover, we found that p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death in U87 and T98 cell lines, which are reverted by N-acetyl cysteine pretreatment. Conversely, U251 cell line showed a resistant phenotype in response to axitinib treatment, as evidenced by cell cycle arrest but no sign of cell death. The combinatorial use of axitinib with other therapies, with the aim of inhibiting multiple signaling pathways involved in tumor growth, can increase the efficiency of this TKI. Thus, we addressed the combined effects of axitinib with no toxic doses of the proteasome inhibitor bortezomib on the growth of U87 and T98 axitinib- sensitive and axitinib-resistant U251 cell lines. Compared to single treatments, combined exposure was more effective in inhibiting cell viability of all glioma cell lines, although with different cell death modalities. The regulation of key DDR and cell cycle proteins, including Chk1, γ-H2AX and p21(Waf1/Cip1) was also studied in glioma cell lines. Collectively, these findings provide new perspectives for the use of axitinib in combination with Bortezomib to overcome the therapy resistance in gliomas

Ricordi. Nuova edizione e introduzione storica

Giovanni di Pagolo Morelli’s Ricordi, long known to historians, are published here for the first time in an integral version which is also linguistically faithful to the original manuscript. This new critical edition is accompanied by a long introductory essay on the author, the intentions of his work and the results it had by the heirs to whom it was addressed. The 74 years of Giovanni Morelli’s life, from the 1370s to the mid 1440s, are placed in a decisive time span for the history of Florence, and they are marked by a strong social mobility of which the Morellis, a family with humble origins, were the protagonists. Reading the Ricordi, and combining them with the analysis of the substantial remaining documentation borne by the author and his family, help understand the strong push to social rise which animated Morelli, and the reasons for his descendants’ position among Florence’s prominent family scene of the late 15th century

C-reactive protein level predicts mortality in COPD: a systematic review and meta-analysis

The prognostic role of baseline C-reactive protein (CRP) in chronic obstructive pulmonary disease (COPD) is controversial. In order to clarify this issue, we performed a systematic review and meta-analysis to assess the predictive effect of baseline CRP level in COPD patients. 15 eligible articles focusing on late mortality in COPD were included in our study. We performed a random-effects meta-analysis, and assessed heterogeneity and publication bias. We pooled hazard ratio (HR) estimates and their 95% confidence intervals on mortality for the comparison between the study-specific highest category of CRP levelversusthe lowest category. In overall analysis, elevated baseline CRP levels were significantly associated with higher mortality (HR 1.53, 95% CI 1.32–1.77,I2=68.7%, p<0.001). Similar results were observed across subgroups. However, higher mortality risk was reported in studies using a cut-off value of 3 mg·L−1(HR 1.61, 95% CI 1.12–2.30) and in those enrolling an Asiatic population (HR 3.51, 95% CI 1.69–7.31). Our analysis indicates that baseline high CRP level is significantly associated with higher late mortality in patients with COPD. Further prospective controlled studies are needed to confirm these data

Novel methodologies for solving the inverse unsteady heat transfer problem of estimating the boundary heat flux in continuous casting molds

In this article, we investigate the estimation of the transient mold-slab heat flux in continuous casting molds given some thermocouples measurements in the mold plates. Mathematically, we can see this problem as the estimation of a Neumann boundary condition given pointwise state observations in the interior of the domain. We formulate it in a deterministic inverse problem setting. After introducing the industrial problem, we present the mold thermal model and related assumptions. Then, we formulate the boundary heat flux estimation problem in a deterministic inverse problem setting using a sequential approach according to the sequentiality of the temperature measurements. We consider different formulations of the inverse problem. For each one, we develop novel direct methodologies exploiting a space parameterization of the heat flux and the linearity of the mold model. We construct these methods to be divided into a computationally expensive offline phase that can be computed before the process starts, and a cheaper online phase to be performed during the casting process. To conclude, we test the performance of the proposed methods in two benchmark casesAgencia Estatal de Investigación, Grant/Award Number: PID2019-105615RBI00/AEI; European Research Council, Grant/Award Number:765374; H2020 Marie Skłodowska-Curie Actions, Grant/Award Number: 681447; Ministerio de Economía, Industria y Competitividad, Gobierno de España, Grant/Award Number: MTM2015-68275-RS

Detection of bovine mitochondrial DNA in ruminant feeds: a molecular approach to test for the presence of bovine-derived materials.

A ban on ruminant-derived proteins in ruminant feeds has been introduced as a preventive measure to avoid the spread of bovine spongiform encephalopathy (BSE), as well as to minimize any potential risk of BSE transmission from bovines to humans. In the absence of commercially available efficient methods for identification of bovine-derived proteins in animal feeds, we developed a rapid and sensitive polymerase chain reaction (PCR)-based assay which allows detection and identification of a bovine-specific mitochondrial DNA sequence from feedstuffs. The amplified product encodes for the whole ATPase subunit 8 and the amino-terminal portion of the ATPase subunit 6 proteins, which are known to exhibit a relatively low degree of conservation among vertebrates. The specific amplification of such a bovine mitochondrial sequence from reference feedstuff samples was demonstrated by means of both direct sequencing and single-strand conformational analysis of the PCR product. Specificity was also confirmed by the absence of detectable homologous PCR product when using reference feedstuff samples lacking bovine-derived meat and bonemeals, or genomic DNA samples from vertebrates whose offals are commonly included in animal feeds. This method allows detection of the presence of bovine mitochondrial DNA in feedstuffs containing less than 0.125% of bovine-derived meat and bonemeals. Furthermore, it does not appear to be considerably affected by prolonged heat treatment. DpnII and SspI restriction endonuclease digestions of the unpurified PCR product may be used routinely to confirm the bovine origin of the amplified sequence. Since this method is specific, rapid, and sensitive, it could be successfully utilized as a routine control assay to evaluate the presence of bovine-derived meat and bonemeals in ruminant feeds