Sintesi di 1,10-fenantroline chirali a simmetria C₂ derivati da monoterpeni naturali quali utili leganti per la catalisi asimmetrica

Nell’ambito dei leganti azotati, la sintesi di 1,10-fenantroline (phens) chirali ed il loro uso quali leganti chirali catalitici è stato poco investigato per le difficoltà incontrate nella preparazione dei più semplici analoghi a simmetria C2. Recentemente abbiamo riportato una nuova via sintetica per la preparazione di phens chirali a simmetria C2

Histoire des sociétés européennes, XIXe-XXe siècles. Liens, réseaux, configurations

Maurizio Gribaudi, directeur d’études Compte rendu non communiqué. Olivier Abel, professeur à l’Institut protestant de théologie de ParisMaurizio Gribaudi, directeur d’étudesGiovanni Levi, professeur à l’Université de VeniseSabina Loriga, maître de conférences Compte rendu non communiqué. Sabina Loriga, maître de conférences L’expérience individuelle : la subjectivité et l’acteur dans les processus historiques Au cours de l’année 2000-2001 nous avons continué notre réflexion sur la valeur heu..

Sintesi di nuovi leganti chirali dipiridilmetanici e loro applicazione nella sostituzione allilica palladio-catalizzata

In questo contesto, viene qui descritta la preparazione di nuove bispiridine chirali di tipo 2 e 3 formalmente ottenute per introduzione di una giunzione dimetilmetanica tra i due anelli piridinici di 1. Infine è stata investigata la capacità delle nuove bispiridine di influenzare la stereoselettività nella reazione di sostituzione allilica palladio-catalizzata. I risultati saranno riportati e discuss

Sintesi di nuove 6,7-diamminochinoline quali intermedi per la preparazione di molecole ad attività biologica

In questa comunicazione viene affrontato un nuovo approccio alla sintesi di 6,7-diamminochinoline indispensabili per ottenere sintoni triiclici lineari da funzionalizzare nello spezzone piridinico della molecola

Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders

Compounds targeting the inflammasome-caspase-1 pathway could be of use for the treatment of inflammation and inflammatory diseases. Previous caspase-1 inhibitors were in great majority covalent inhibitors and failed in clinical trials. Using a mixed modelling, computational screening, synthesis and in vitro testing approach, we identified a novel class of non-covalent caspase-1 non cytotoxic inhibitors which are able to inhibit IL-1β release in activated macrophages in the low μM range, in line with the best activities observed for the known covalent inhibitors. Our compounds could form the basis of further optimization towards potent drugs for the treatment of inflammation and inflammatory disorders including also dysregulated inflammation in Covid 19

I 3,6-diazabiciclo[3.1.1]eptani: una nuova serie di potenti agonisti per i recettori µ degli oppioidi

In questa comunicazione presentiamo la sintesi di una nuova serie di diazabicicloalcani, i 3,6-diazabiciclo[3.1.1]eptani ed i preliminari dati biologici dei composti sintetizzati

THE PRATI DI STUORES/STUORES WIESEN SECTION (DOLOMITES, ITALY): A CANDIDATE GLOBAL STRATOTYPE SECTION AND POINT FOR THE BASE OF THE CARNIAN STAGE

The Prati di Stuores/Stuores Wiesen section (Dolomites, Italy) is proposed as a candidate Global Stratotype Section and Point for the base of the Carnian Stage. In addition to being a famous, richly fossiliferous locality, it includes the type-section of the Cordevolian substage. The section is located near Pralongià, along the southern slope of the crest separating the Badia/Abtei and Cordevole valleys. Below the levels with Trachyceras aon, the section contains a rich ammonoid fauna that chacterizes the lower part of the Regoledanus Subzone and subsequently records the first appearances of the mid-high latitude genus Daxatina (Daxatina sp., D. cf. canadensis) and of traditional Trachyceras with species different from T. aon. Moreover, the Daxatina cf. canadensis Subzone is recognised above the Regoledanus Subzone. Very rare conodonts of the Budurovignatus group and species of Gladigondolella from the diebeli Assemblage Zone occur. Gondolella polygnatyformis, already known from the Aon Subzone, is absent. Palynomorphs, foraminifers, gastropods, bivalves, brachiopods, microcrinoids and holothurian sclerites were studied. Variations in frequency and taxonomic diversity of these faunas suggest anaerobic-disaerobic bottom conditions for the lower-middle part of the section (0-105 m), followed by a more stable oxygen content in the upper portion. Magnetostratigraphy showed four intervals with normal polarity and three intervals with reversed polarity. The Daxatina cf. canadensis Subzone falls close to the normal polarity interval S2n. The present study proposes the FAD of the cosmopolitan genus Daxatina as a marker of the base of the Carnian Stage, placing it at a lower stratigraphic level than previously indicated in the Stuores area. The Prati di Stuores section is proposed as GSSP of the Ladinian-Carnian boundary.&nbsp

Proetex: protective e-textiles to enhance the safety of emergency/disaster operators: current state of the projects' achievements

Proetex is a European Integrated Project dedicated to the realization of a micro- and nano-technology-based wearable equipment for emergency operators. During the first 3 years of work, two different and progressively improved versions of a complete “smart” uniform for fire-fighters and emergency rescuers have been realized. These garments aim at monitoring both physiological parameters, position and posture of the operators and the presence of external potential sources of danger and to send these data to a remote coordinating unit. In the following, the main issues of the design and realization will be described and discussed

Morphologies

Séminaire commun avec la participation de : Olivier Abel, Luciano Boi, Jean-Claude Bonne, Marion Carel, Giovanni Careri, Enrico Castelli Gattinara, Patrice Ceccarini, Danièle Cohn, Georges Didi-Huberman, Fernando Gil, Maurizio Gribaudi, Ryozo Hiyama, Bernard Jaulin, Gérard Jorland, Farhad Khosrokhavar, Hervé Le Bras, Giovanni Levi, Sabina Loriga, Silvia Mancini, Jean Petitot, Pierre Rosenstiehl, Carlo Severi, Wiktor Stoczkowski, Lorraine Verner Compte rendu non communiqué

Morphologies

Séminaire commun avec la participation de : Olivier Abel, Luciano Boi, Jean-Claude Bonne, Marion Carel, Giovanni Careri, Enrico Castelli Gattinara, Patrice Ceccarini, Ryozo Hiyama, Georges Didi-Huberman, Maurizio Gribaudi, Bernard Jaulin, Gérard Jorland, Farhad Khosrokhavar, Hervé Le Bras, Giovanni Levi, Sabina Loriga, Silvia Mancini, Zacarías Moutoukias, Jean Petitot, Pierre Rosenstiehl, Carlo Severi, Irène Tamba, Lorraine Verner, Wiktor Stoczkowski Compte rendu non communiqué