A multi-physics approach to simulate the RF heating 3D power map induced by the proton beam in a beam intercepting device

The project High Luminosity Large Hadron Collider (HL-LHC) calls for a streaking beam intensity and brightness in the LHC machine. In such a scenario, beam-environment electromagnetic interactions are a crucial topic: they could lead to uneven power deposition in machine equipment. The resulting irregular temperature distribution would generate local thermal gradients, this would create mechanical stresses which could lead to cracks and premature failure of accelerator devices. This work presents a method to study this phenomenon by means of coupled electro-thermomechanical simulations. Further, an example of application on a real HL-LHC device is also discussed

Accurate Numerical Modelling of MV and HV Resistive Dividers

An effective computational tool for the simulation and design of voltage dividers has been realized. It takes advantage from a finite element procedure for the accurate computation of the divider stray capacitances. These latter are then the input of a circuit solver procedure based on the modified node potential technique, which provides the divider frequency response. Furthermore, a test divider has been setup for the purpose of the tool validation. A very good agreement has been found between measured and computed results. This paper highlights that a correct representation of the resistors is necessary in the FEM model, during the computation of the stray parameters. This issue has been clarified for the first time in this paper. In addition, a comparison between FEM and BEM methods has been carried out before the implementation of the numerical code, stating the superior effectiveness of FEM. The computational tool has been finally tested on a real voltage divider. Good results have been found in terms of computational accuracy. Limited discrepancies between measured and computed results have been found up to 10 kHz, being 5.7 % for the scale factor and less than 24 mrad for the phase errors

Analysis on the mechanical effects induced by beam impedance heating on the HL-LHC target dump injection segmented (TDIS) absorber

The High Luminosity Large Hadron Collider (HL-LHC) Project at CERN calls for increasing beam brightness and intensity. In such a scenario, critical accelerator devices need to be redesigned and rebuilt. Impedance is among the design drivers, since its thermo-mechanical effects could lead to premature device failures. In this context, the current work reports the results of a multiphysics study to assess the electromagnetic and thermo-mechanical behaviour of the Target Dump Injection Segmented (TDIS). It first discusses the outcomes of the impedance analysis performed to characterise the resistive wall and the high order resonant modes (HOMs) trapped in the TDIS structures. Then, their RF-heating effects and the related temperature distribution are considered. Finally, mechanical stresses induced by thermal gradients are studied in order to give a final validation on the design qualit

C1–C2 Instability Associated with Periodontoid Inflammatory Tissue Leading to Subarachnoid Hemorrhage: A Case Report and Review of the Literature

Abstract The authors present a case of atlantoaxial instability associated with C1–C2 inflammatory tissue leading to subarachnoid hemorrhage. A 65-year-old male patient arrived in June 2011 to the emergency unit for cervical pain and fever. Imaging studies documented periodontoid pseudotumor at C1–C2 level. Infective disease was suspected; the patient was therefore hospitalized and treated with antibiotics. Subsequent computed tomographic (CT) scans revealed C1–C2 instability. In August, the patient showed acute neurological deterioration and coma. Urgent brain CT revealed a hemorrhagic lesion which caused compression on the medulla oblongata, subarachnoid hemorrhage, and ventricular dilatation. An external ventricular drainage was positioned. Angio-CT and angiography did not show any vascular abnormalities. Cervical magnetic resonance imaging documented a solid tissue lesion between the atlas arch and axis. The lesion was associated with an epidural and subdural hematoma, exerting compression on brainstem. The patient underwent posterior decompression and C1–C2 fusion according to Harms technique in October, with significant clinical improvement. The authors present a case of atlantoaxial instability associated with a periodontoid pseudotumor at C1–C2 level determining dural sac compression. The patient showed an acute neurological deterioration caused by bleeding of the solid component of the cervical lesion. Hemorrhage of the solid component of periodontoid masses linked to atlantoaxial instability has not yet been reported in literature. To the best of our knowledge, this is the first case of C1–C2 instability with periodontoid pseudotumor leading to subarachnoid hemorrhage

Expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in mouse tissues and cell lines using an antibody against the enzyme amino-terminal domain

We have produced a polyclonal antibody that specifically recognizes cGMP-binding cGMP-specific phosphodiesterase (PDES). The antibody was raised in rabbit using as immunogen a fusion protein, in which glutathione S-transferase was coupled to a 171 amino acid polypeptide of the N-terminal region of bovine PDE5. The antibody is able to immunoprecipitate PDES activity from mouse tissues and neuroblastoma extracts while it has no effect on all other PDE isoforms present in the extracts. PDES activity recovered in the immunoprecipitates retains its sensitivity to specific inhibitors such as zaprinast (IC50 = 0.6 muM) and sildenafil (IC50 = 3.5 nM), Bands of the expected molecular mass were revealed when solubilized immunoprecipitates were analysed in Western blots. The antibody selectively stained cerebellar Purkinje neurones, which are known to express high levels of PDES mRNA. Western blot analysis of mouse tissues revealed the highest expression signal in mouse lung, followed by heart and cerebellum, while a lower signal was evident in brain, kidney and a very low signal was present in the liver. In the hybrid neuroblastoma-glioma NG108-15 cells the antibody revealed a high PDE5 induction after dibutyryl-cAMP treatment. (C) 2001 Elsevier Science B,V, All rights reserved

Effects of dietary protein restriction on fibrinogen and albumin metabolism in nephrotic patients

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Contact force observer for space robots

In this paper, the problem of estimating a contactwrench at the end-effector for a space robot is addressed. Tothis aim, a generalized force observer based on a base-jointsdynamics is first reviewed. Then, a different formulation isproposed, which is based on a centroidal-joints dynamics. Theproposed observer features interesting decoupling propertiesfrom the base linear velocity that lead to a more practicaland better-performing estimation when limitations in real spacescenarios are considered. The two observers are comparedand the advantage of the proposed one is shown through asimulation example featuring a free-floating robot composed ofa 7 degrees-of-freedom (DOF) arm mounted on a 6DOF movingbase