34 research outputs found
Minimal flavour violation extensions of the seesaw
We analyze the most natural formulations of the minimal lepton flavour
violation hypothesis compatible with a type-I seesaw structure with three heavy
singlet neutrinos N, and satisfying the requirement of being predictive, in the
sense that all LFV effects can be expressed in terms of low energy observables.
We find a new interesting realization based on the flavour group (being and respectively the SU(2) singlet and
doublet leptons). An intriguing feature of this realization is that, in the
normal hierarchy scenario for neutrino masses, it allows for sizeable
enhancements of transitions with respect to LFV processes involving
the lepton. We also discuss how the symmetries of the type-I seesaw
allow for a strong suppression of the N mass scale with respect to the scale of
lepton number breaking, without implying a similar suppression for possible
mechanisms of N productionComment: 14 pages, 6 figure
Direct CP violation in charm and flavor mixing beyond the SM
We analyze possible interpretations of the recent LHCb evidence for CP
violation in D meson decays in terms of physics beyond the Standard Model. On
general grounds, models in which the primary source of flavor violation is
linked to the breaking of chiral symmetry (left-right flavor mixing) are
natural candidates to explain this effect, via enhanced chromomagnetic
operators. In the case of supersymmetric models, we identify two motivated
scenarios: disoriented A-terms and split families. These structures predict
other non-standard signals, such as nuclear EDMs close to their present bounds
and, possibly, tiny but visible deviations in K and B physics, or even sizable
flavor-violating processes involving the top quark or the stops. Some of these
connections, especially the one with nuclear EDMs, hold beyond supersymmetry,
as illustrated with the help of prototype non-supersymmetric models.Comment: 30 pages, 6 figure
Probing forces of menisci: what levels are safe for arthroscopic surgery
Purpose To facilitate effective learning, feedback on performance during arthroscopic training is essential. Less attention has been paid to feedback on monitoring safe handling of delicate tissues such as meniscus. The goal is to measure in vitro probing forces of menisci and compare them with a theoretical maximum probing force (TMPF). Method Menisci samples of ten cadavers were mounted on force platforms to measure probing forces up to 20 N in three directions. Nineteen subjects participated: six novices (experience 60 arthroscopies), and three faculty (>250 a year). All had to perform three tasks on each meniscus sample with an arthroscopic probe: push three times on the superior meniscal surface, perform one continuous run on the superior meniscal surface, and push three times on the inferior meniscal surface. The absolute maximum probing force (AMPF) was determined for each condition. A multivariable linear regression analysis was performed to assess the influence of experience on the force magnitude (P < 0.05). AMPFs were compared to the TMPF (estimated to be 8.5 N). Results The AMPF of the push task was on average 2.8 N (standard deviation (SD) of 0.8 N), of the continuous run task 2.5 N (SD 0.9 N), and of the pull task 3.9 N (SD 2.0 N). Significant difference was present between experts and novices (P < 0.05). The AMPFs are in the same order of magnitude as the TMPF. Conclusion The results indicate the necessity of using a safety level for tissue manipulation when training arthroscopy and a value for is magnitude.Biomechanical EngineeringMechanical, Maritime and Materials Engineerin
Higgs-mediated FCNCs: Natural Flavour Conservation vs. Minimal Flavour Violation
We compare the effectiveness of two hypotheses, Natural Flavour Conservation
(NFC) and Minimal Flavour Violation (MFV), in suppressing the strength of
flavour-changing neutral-currents (FCNCs) in models with more than one Higgs
doublet. We show that the MFV hypothesis, in its general formulation, is more
stable in suppressing FCNCs than the hypothesis of NFC alone when quantum
corrections are taken into account. The phenomenological implications of the
two scenarios are discussed analysing meson-antimeson mixing observables and
the rare decays B -> mu+ mu-. We demonstrate that, introducing flavour-blind CP
phases, two-Higgs doublet models respecting the MFV hypothesis can accommodate
a large CP-violating phase in Bs mixing, as hinted by CDF and D0 data and,
without extra free parameters, soften significantly in a correlated manner the
observed anomaly in the relation between epsilon_K and S_psi_K.Comment: 27 pages, 4 figures. v3: minor modifications (typos corrected and few
refs. added), conclusions unchanged; journal versio
Three-dimensional structure of a viral genome-delivery portal vertex.
DNA viruses such as bacteriophages and herpesviruses deliver their genome into and out of the capsid through large proteinaceous assemblies, known as portal proteins. Here, we report two snapshots of the dodecameric portal protein of bacteriophage P22. The 3.25-Ă
-resolution structure of the portal-protein core bound to 12 copies of gene product 4 (gp4) reveals a ~1.1-MDa assembly formed by 24 proteins. Unexpectedly, a lower-resolution structure of the full-length portal protein unveils the unique topology of the C-terminal domain, which forms a ~200-Ă
-long α-helical barrel. This domain inserts deeply into the virion and is highly conserved in the Podoviridae family. We propose that the barrel domain facilitates genome spooling onto the interior surface of the capsid during genome packaging and, in analogy to a rifle barrel, increases the accuracy of genome ejection into the host cell