acute allergic reactions to anisakis simplex after ingestion of anchovies

symptoms after ingestion of esh. The etiological role of The study population also comprised 33 controls grouped as: Anisakis simplex was evaluated in 49 adult subjects with ‐ 24 individuals who never ate raw or undercooked esh during acute allergic symptoms after ingestion of anchovies. their lifetime, of whom 5 were non-atopic healthy subjects, Serum-specie c IgE and prick tests to anchovy were nega- 9 were non-atopic patients with physical urticarias, and 10 tive in each patient. Specie c IgE reactions to Anisakis had a personal history of atopy (atopic dermatitis, allergic asthma and/or rhinitis); were positive in 45 patients and skin tests in 43. Only 3 ‐ 9 regular consumers of raw-esh products with no antepatients with allergy to the nematode were atopic. cedents of atopy or any allergic reactions. However, IgE responses to Anisakis were also observed After an adequate washout period from active treatments, in in habitual consumers of raw e sh, without any clinical vivo tests were performed in both patients and controls: manifestations, suggesting that the relevance of results of ‐ skin-prick tests (SPTs) with common aeroallergens conventional tests has to be interpreted on the basis of (Stallergenes Italia, Saronno, Varese, Italy)

Association Between Melanoma Risk and Height: A Narrative Review

The link between anthropometric indices, including height, and cancer risk and/or progression has attracted considerable interest in recent years. Adult height results from the complex interplay between genetic, hormonal, nutritional, and other environmental factors and has been found to contribute to the risk of several selected malignancies, although it has not been implicated as a real cause per se. A number of studies have investigated the height-melanoma relationship, showing controversial results so far. In this review, we summarize the epidemiological data regarding the association between height and melanoma risk and analyze the potential underlying mechanisms

Photodermatitis caused by oral ketoprofen: Two case reports

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Drug-induced eruptive melanocytic nevi

The sudden eruption of melanocytic nevi has been associated with a number of conditions, such as bullous skin diseases, immunodeficiency and immunosuppression. The exact mechanisms leading to the development of eruptive melanocytic nevi are unknown. Areas covered: The aim of this article is to review the literature concerning eruptive melanocytic nevi following the administration of immunosuppressive drugs and other medications. Expert opinion: The literature regarding the development of eruptive nevi in association with pharmacological therapies includes a relatively low number of reports. Prevalence of this phenomenon is likely to be underestimated, thus reporting should be encouraged in order to better define the actual significance and related clinical implications. The development of multiple melanocytic nevi during immunosuppressive treatments highlights the importance of immune system integrity in the regulation of nevi growth. The observation of eruptive nevi as an unexpected effect of targeted therapies for specific types of cancer, including melanoma, provided intriguing hints to understand the mechanisms underlying this paradoxical event. The synergistic role of additional triggers in the occurrence of drug-induced eruptive nevi has not been explored and may be an interesting area of research

Efficacy of etanercept for the treatment of psoriasis: an overview of the Italian clinical experience from the real-life setting and independent studies

Etanercept is a dimeric fusion protein consisting of the extracellular portion of tumor necrosis factor (TNF) p75 receptor and human IgG1 Fc fragment, which, similarly to the physiological soluble TNF receptor, is capable of binding TNF-\u3b1 and lymphotoxin. The mechanism of action of etanercept in psoriatic disease and other approved indications is mediated by the neutralization of soluble TNF-\u3b1 leading to a modulation of the immune response. Clinical trials have provided robust evidence supporting the sustained efficacy and safety of etanercept in psoriasis, as both intermittent and continuous therapy. The aim of this manuscript was to review the efficacy profile of etanercept in psoriasis according to the clinical experience gained by Italian dermatological centers and derived from the available publications on this topic. Everyday practice confirms that etanercept is a valuable and flexible therapeutic tool for the management of high-need psoriasis patients

Focus on the role of substance P in chronic urticaria

Abstract Background Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. Methods Literature data regarding the possible role of SP in chronic urticaria/chronic spontaneous urticaria (CSU) have been reviewed and summarized in this manuscript. This review is based on pertinent articles that were retrieved by a selective literature search in the PubMed database. Articles in English published up to July 2018 were taken into consideration. Results Recent studies in patients with CSU have demonstrated that circulating levels of SP are significantly elevated, in correlation with disease severity, and that SP-positive basophils are upregulated. SP has been shown to trigger degranulation in basophils derived from CSU patients. Moreover, SP can be involved in pseudoallergic reactions and may act as a histamine-releasing factor in a subset of patients with CSU. Current evidence suggests that the biological activity of SP can be exerted not only through the conventional NK-1 receptor but also through the recently identified Mas-related G protein-coupled receptors. MRGPRX2 can cause mast cell activation and has been found to be upregulated in the skin of patients with severe chronic urticaria. Conclusions Many findings seem to support the pathogenic involvement of SP in chronic urticaria/CSU. However, further studies are necessary to elucidate the role of SP as a mediator in CSU pathogenesis and a potential new therapeutic target