The effect of serum 25(OH) vitamin D on hemogram parameters

Objective: Vitamin D that has pleiotropic hormone characteristics is a fat soluble vitamin. In general, vitamin D is known to be associated with rickets, but the studies show that vitamin D also acts on tissues and cells other than bone itself. In this study, we aimed to investigate if vitamin D has any effects on hemogram parameters or not. Methods: This retrospective study was done with the data obtained from 243 female and 59, totally 302 patients. Vitamin D level and hemogram parameters [(red blood cell (RBC), hemoglobin (Hb), white blood cell (WBC), platelet (PLT), mean platelet volume (MPV), and red cell distribution width (RDW)] of patients were obtained. Patients were divided into 4 groups according to their levels of vitamin D: Group 1: < 10 ng/mL; Group 2: 10-19 ng/mL; Group 3: 20-29 ng/mL, and Group 4: 30-60 ng/mL. Results: There were no significant differences in RBC, Hb, WBC, PLT, MPV, and RDW between the groups (p>0.05). Also, there was no correlation between the hemogram parameters and vitamin D. Conclusion: According to the literature, there are a lot of studies that show the relationship between vitamin D and WBC, RBC, and PLT. However, contrary to the previous studies, we were unable to find any significant relationship between vitamin D and hemogram parameters. These results serve the idea that the effects of vitamin D on the hematopoietic system should be further investigated experimentally and clinically

Çocuk alerji kliniğinde izlenen anafilaksili olguların özellikleri

Introduction: Anaphylaxis is a severe hypersensitivity reaction that can be lifethreatening. The frequency of anaphylaxis varies among the societies. In this study, the demographic characteristics, clinical course, triggering agents and treatment approaches of the patients who were diagnosed with anaphylaxis in our pediatric allergy clinic were evaluated. Materials and Methods: The medical records of children who received a diagnosis of anaphylaxis between 2010 and 2012 were retrospectively evaluated. Results: Between 2010 and 2012, 39.371 patients were admitted to our outpatient clinic. Sixty-six patients (49 male, 17 female) with a mean age of 8.9±5.3 years were evaluated as anaphylaxis. In 37 of the cases, anaphylactic attack occurred at home. Dermatological symptoms were the most frequent complaints. A probable cause of anaphylaxis was identified in all the patients except for five of them (92.4%). Food was the cause of anaphylaxis in 25 of the cases, followed by hymenoptera sting in 22 patients and drugs in 14 patients. The most common causes of anaphylaxis according to age groups were food, hymenoptera sting and drugs (0-3 years, 4-14 years and over the age of 14, respectively). Antihistamines were applied to all patients. The other medications that were applied were corticosteroid, oxygen, intravenous fluids, adrenaline (21/66), and salbutamol. Conclusions: The common cause of anaphylaxis in children is food allergens. However, the frequency decreases by age and other causes are more common than food. In our country, usage of adrenaline for the treatment of anaphylaxis is low.Giriş: Anafilaksi hayatı tehdit edebilen, ciddi bir hipersensitivite reaksiyonudur. Anafilaksi sıklığı toplumlara göre değişmektedir. Bu çalışmada çocuk alerji kliniğimizde anafilaksi tanısı konulan hastaların demografik özellikleri, klinik seyirleri, tetikleyici ajanlar ve tedavi yaklaşımları değerlendirilmiştir. Gereç ve Yöntem: 2010-2012 yılları arasında anafilaksi tanısı konulan çocukların tıbbi kayıtları retrospektif olarak değerlendirildi. Bulgular: Polikliniğimize 2010-2012 yılları arasında 39,371 hasta başvurdu. Yaş ortalaması 8,9±5,3 yıl olan 66 çocuk (49 erkek, 17 kız) anafilaksi olarak değerlendirildi. Olguların 37’sinde anafilaksi ev ortamında gerçekleşmişti. Dermatolojik semptomlar en sık başvuru şikayetleriydi. Beş hasta dışındaki tüm hastalarda (%92,4) olası anafilaksi nedeni tanımlandı. Besinler olguların 25’inde anafilaksi nedeniydi. Bunu takiben, olguların 22’sinde arı sokması, 14’ünde ilaçlar anafilaksi nedeniydi. Yaşlara göre en sık anafilaksi nedenleri besinler, arı sokması ve ilaçlardı (sırasıyla 0-3 yaş, 4-14 yaş ve 14 yaş üstü). Tüm hastalara antihistaminik uygulanmıştı. Uygulanan diğer ilaçlar kortikosteroid, oksijen, intravenöz sıvı, adrenalin (21/66) ve nebülize salbutamol idi

Stężenie białka S100B w surowicy jako przydatny wskaźnik w zespole obturacyjnego bezdechu podczas snu

Background and purpose We aimed to underline the importance of serum S100B protein as a useful biochemical marker in patients with obstructive sleep apnea syndrome (OSAS). Material and methods Forty-three newly diagnosed patients with OSAS (median apnea-hypopnea index [AHI, events/hour]: 37.5 [range 11.3–137]) and 25 subjects with AHI &lt; 5 (median AHI: 4.4 [range 0.7–4.8]) were included in the study. Serum S100B protein level was tested in serum samples taken after polysomnography in both groups and the difference between OSAS patients and the control group regarding that level was assessed. In addition, the association of S100B protein serum level with age, body mass index, AHI, mean O2 saturation percentage during sleep, minimum O2 saturation value (%) at the end of the apneas, and the time spent at an O2 saturation less than 90% were analyzed in the OSAS patient group. Results Median serum S100B protein level was 133.7 pg/mL (range 20.97–230.70 pg/mL) in patients with OSAS and 16.1 pg/mL (range 10.1–22.9 pg/mL) in the control group (p &lt; 0.005). Serum S100B protein level did not correlate with any studied variable (p &gt; 0.05 for each correlation coefficient). Conclusions Serum S100B protein level is increased in patients with OSAS and may be a useful biochemical marker in those patients.Wstęp i cel pracy Celem pracy było podkreślenie znaczenia stężenia białka S100B w surowicy jako przydatnego wskaźnika biochemicznego u chorych na zespół obturacyjnego bezdechu podczas snu (obstructive sleep apnea syndrome – OSAS). Materiał i metody W badaniu wzięło udział 43 chorych ze świeżo rozpoznanym OSAS [mediana wskaźnika bezdechów/spłyconych oddechów, AHI (epizody na godzinę): 37,5 (zakres: 11,3–137)] oraz 25 osób z AHI &lt; 5 [mediana: 4,4 (0,7–4,8)] stanowiących grupę kontrolną. W obu grupach zmierzono stężenie białka S100B w surowicy pobranej po wykonaniu polisomnografii i sprawdzono różnicę w tym zakresie między grupami. Ponadto w grupie chorych na OSAS określono korelację między stężeniem białka S100B w surowicy a wiekiem, wskaźnikiem masy ciała, AHI, średnim wysyceniem krwi tętniczej tlenem podczas snu, najmniejszym wysyceniem krwi tętniczej tlenem na zakończenie okresu bezdechu oraz czasem, w którym wysycenie krwi tętniczej tlenem wynosiło &lt; 90%. Wyniki Mediana stężenia białka S100B w surowicy wyniosła 133,7 pg/ml (zakres: 20,97–230,70 pg/ml) u chorych na OSAS oraz 16,1 pg/ml (zakres: 10,1–22,9 pg/ml) w grupie kontrolnej (p &lt; 0,005). Stężenie białka S100B w surowicy nie korelowało z żadną ocenianą zmienną (p&gt; 0,05 dla każdego współczynnika korelacji). Wnioski Stężenie białka S100B w surowicy jest zwiększone u chorych na OSAS i może być przydatnym wskaźnikiem biochemicznym u tych pacjentów

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