Dampening prey cycle overrides the impact of climate change on predator population dynamics : a long-term demographic study on tawny owls

Funded by ERA-Net BiodivERsA NERC. Grant Numbers: NE/E010660/1, NE/F021402/1, NE/G002045/1Peer reviewedPublisher PD

La Cañada Real de San Vicente en los Bosquejos Planimétricos de 1896

Trabajo presentado en las jornadas “X Aniversario de la señalización de la Cañada Real UA. Pasado, presente y futuro de las vías pecuarias, la trashumancia y el pastoralismo”, celebradas los días 18 y 19 de octubre de 2017 en la Universidad de Alicante.A partir de los Bosquejos planimétricos mandados a formar por la ley de 24 de agosto de 1896, el presente trabajo reconstruye los detalles sobre la Cañada Real del campus de la Universidad de Alicante, introduciendo aspectos vinculados con la evolución y función trashumante de la misma

Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area

Autoimmunity; Glycemic control; Type 1 diabetes mellitus;Autoinmunidad; Control Glicémico; Diabetes mellitus tipo 1Autoimmunitat; Control glucèmic; Diabetis mellitus tipus 1Aim: To assess the prevalence of autoimmune diseases (AID) in patients with type 1 diabetes (T1D) and to evaluate whether the rate of diabetes-related complications differs depending on the presence of AID. Methods: Cross-sectional analysis of 13,570 T1D patients aged ≥ 18 years registered in the SIDIAP database. The association between AID and diabetes-related complications was assessed by multivariable logistic regression models. Results: The prevalence of AID was 18.3% with thyroid AID being the most common. Patients with T1D and AID were more often female and their current age, age of diabetes onset and diabetes duration were higher. Patients with only thyroid AID experienced a lower risk of peripheral artery disease (odds ratio [OR] = 0.51, 95%; confidence interval [CI] 0.31 to 0.81) and kidney disease (OR = 0.68, 95%; 95% CI 0.54 to 0.85), whereas patients with other AID had an increased risk of ischemic heart disease (OR = 1.48, 95%; 95% CI 1.04 to 2.06). Conclusions: The burden of diabetes-related complications in patients with T1D differs according to the type of additional AID. The presence of diabetes complications is lower in those with autoimmune thyroid disease while the presence of other AID is associated with higher rates of ischemic heart disease

O brincar e os contextos físicos escolares: uma reflexão sobre a educação infantil no Município de São Paulo

Reconhecidamente, o brincar contribui para o desenvolvimento das crianças sob uma série de aspectos, incluindo suas dimensões cognitivas, afetivas e motoras. Em linhas gerais, percebe-se uma crescente valorização das instituições escolares em relação aos elementos lúdicos da aprendizagem. Todavia, nos grandes centros urbanos como é o caso da cidade de São Paulo, os espaços escolares destinados ao brincar foram drasticamente influenciados pela estrutura arquitetônica das escolas. Diante da necessidade de ampliação do número de vagas, as concessões oferecidas à iniciativa privada contribuíram para uma reconfiguração dos espaços escolares, uma vez que escolas de pequeno porte, grande parte das vezes, adaptadas a partir de casas térreos ou sobrados passaram a compor o quadro das instituições.  O presente artigo teve por objetivo discutir esta problemática, com especial atenção aos possíveis desdobramentos que ela apresenta sobre o desenvolvimento infantil. Nele são apresentados diversos olhares, sejam eles da antropologia, educação, medicina, arquitetura entre outros, sobre a importância do brincar. Também foi agregado ao estudo o amparo legal associado às dimensões do brincar no contexto escolar. Finalmente, são apresentadas implicações para a atuação do poder público e para o desenvolvimento de pesquisas sobre o referido tema

On the relation between graph distance and Euclidean distance in random geometric graphs

International audienceGiven any two vertices u, v of a random geometric graph G(n, r), denote by d_E(u, v) their Euclidean distance and by d_G(u, v) their graph distance. The problem of finding upper bounds on d_G(u, v) conditional on d_E(u, v) that hold asymptotically almost surely has received quite a bit of attention in the literature. In this paper, we improve the known upper bounds for values of r = \omega\sqrt(log n)) (i.e. for r above the connectivity threshold). Our result also improves the best known estimates on the diameter of random geometric graphs. We also provide a lower bound on d_G(u, v) conditional on d_E(u, v)

Evidence for shared genetic risk factors between lymphangioleiomyomatosis and pulmonary function

Lymphangioleiomyomatosis; Risk factors; Pulmonary functionLinfangioleiomiomatosis; Factores de riesgo; Función pulmonarLimfangioleiomiomatosi; Factors de risc; Funció pulmonarIntroduction Lymphangioleiomyomatosis (LAM) is a rare low-grade metastasising disease characterised by cystic lung destruction. The genetic basis of LAM remains incompletely determined, and the disease cell-of-origin is uncertain. We analysed the possibility of a shared genetic basis between LAM and cancer, and LAM and pulmonary function. Methods The results of genome-wide association studies of LAM, 17 cancer types and spirometry measures (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC ratio and peak expiratory flow (PEF)) were analysed for genetic correlations, shared genetic variants and causality. Genomic and transcriptomic data were examined, and immunodetection assays were performed to evaluate pleiotropic genes. Results There were no significant overall genetic correlations between LAM and cancer, but LAM correlated negatively with FVC and PEF, and a trend in the same direction was observed for FEV1. 22 shared genetic variants were uncovered between LAM and pulmonary function, while seven shared variants were identified between LAM and cancer. The LAM-pulmonary function shared genetics identified four pleiotropic genes previously recognised in LAM single-cell transcriptomes: ADAM12, BNC2, NR2F2 and SP5. We had previously associated NR2F2 variants with LAM, and we identified its functional partner NR3C1 as another pleotropic factor. NR3C1 expression was confirmed in LAM lung lesions. Another candidate pleiotropic factor, CNTN2, was found more abundant in plasma of LAM patients than that of healthy women. Conclusions This study suggests the existence of a common genetic aetiology between LAM and pulmonary function