British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017

Decisions about the use of psychotropic medication in pregnancy are an ongoing challenge for clinicians and women with mental health problems, owing to the uncertainties around risks of the illness itself to mother and fetus/infant, effectiveness of medications in pregnancy and risks to the fetus/infant from in utero exposure or via breast milk. These consensus guidelines aim to provide pragmatic advice regarding these issues. They are divided into sections on risks of untreated illness in pregnancy; general principles of using drugs in the perinatal period; benefits and harms associated with individual drugs; and recommendations for the management of specific disorders

Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients

The aim of the investigation was to detect neuropsychological markers, such as sustained and selective attention and executive functions, which contribute to the vulnerability to schizophrenia especially in young persons. Performance was assessed in 32 siblings and children of schizophrenic patients and 32 matched controls using Wisconsin Card Sorting Test, Colour-Word-Interference-Test, Trail Making Test, and d2-Concentration-Test. The first-degree relatives showed certain impairments on all four tests, in particular, slower times on all time-limited tests. These results suggest the need for more time when completing neuropsychological tasks involving selected and focused attention, as well as cognitive flexibility, as a possible indicator of genetic vulnerability to schizophrenia

Autoimmune diseases in the pedigrees of schizophrenic and control subjects

Autoimmune diseases aggregate in individuals and within pedigrees, and it has been postulated that autoimmune mechanisms may account for a proportion of schizophrenia. Structured questionnaires were used to interview the mothers of 121 DSM-III-R schizophrenic patients and the mothers of 116 controls in order to determine the prevalence of schizophrenia and of autoimmune diseases in their pedigrees. Patients with a schizophrenic first degree relative were significantly more likely to also have a parent or sibling with an autoimmune disease (60% vs. 20%, OR = 6.1, 95% CI = 2.3-16.5, p = 0.0003). A significant excess of insulin dependent diabetes mellitus (IDDM) was present in the parents and siblings of schizophrenic patients (OR = 9.65, 95% CI = 1.3-429.2, p = 0.009). These findings suggest that autoimmune mechanisms may play a role in the aetiology of schizophrenia, particularly familial schizophrenia. Associations have been established between autoimmune diseases and the HLA encoding genes of the major histocompatibility complex on chromosome six, and it may be that some of the genetic liability to schizophrenia involves these genes.link_to_subscribed_fulltex

Family history of autoimmune diseases in psychosis

The mothers of 101 psychotic patients and 116 normal controls were interviewed using a semi-structured questionnaire designed to determine the presence or absence of autoimmune disorders in first degree relatives of the probands. Thyrotoxicosis and insulin-dependent diabetes mellitus were significantly more common in the relatives of the psychotic patients than in the control relatives; in particular thyrotoxicosis was more frequent in the mothers of patients (11%) than the mothers of controls (2.6%). None of the examined characteristics of the patients, including RDC-diagnosis, family history of psychosis, age at onset of psychosis and winter birth, was predictive of thyrotoxicosis- and insulin-dependent diabetes mellitus in relatives.link_to_subscribed_fulltex

Migration and mental health: Japanese Brazilians in Japan and in Brazil Migração e saúde mental: brasileiros descendentes de japoneses no Japão e no Brasil

OBJECTIVE: Brazil is the country with the largest community of Japanese descendants in the world, from a migration movement that started in 1908. However, more recently (1988), a movement in the opposite direction began. Many of these descendants went to Japan for work purposes and suffered mental distress. Some of them sought treatment in Japan, while others returned to Brazil to seek treatment. The aim of the present study was to compare the sociodemographic profile and diagnoses of Japanese Brazilian psychiatric outpatients in Japan (remaining group) and in Brazil (returning group). METHOD: All consecutive Japanese Brazilian outpatients who received care from the psychiatric units in Japan and Brazil from April 1997 to April 2000 were compared. The diagnoses were based on ICD-10 and were made by psychiatrists. Sociodemographic data and diagnoses in Brazil and Japan were compared by means of the Chi-Squared Test. RESULTS: The individuals who returned to Brazil were mostly male and unmarried, had lived alone in Japan, had stayed there for short periods and were classified in the schizophrenia group. The individuals who remained in Japan were mostly female and married, were living with family or friends, had stayed there for long periods and were classified in the anxiety group. Logistic regression showed that the most significant factors associated with the returning group were that they had lived alone and stayed for short periods (OR = 0.93 and 40.21, respectively). CONCLUSION: We conclude that living with a family and having a network of friends is very important for mental health in the context evaluated.<br>OBJETIVO: O Brasil é o país com a maior comunidade de descendentes japoneses do mundo (migração iniciada em 1908). No entanto, mais recentemente (1988) um movimento migratório em direção oposta se iniciou. Muitos desses descendentes têm migrado para o Japão a trabalho e sofrem distúrbios mentais. Alguns deles procuram tratamento no Japão, enquanto outros retornam ao Brasil para se tratarem. O objetivo do presente estudo é comparar o perfil sociodemográfico e diagnósticos dos pacientes ambulatoriais brasileiros descendentes de japoneses que permaneceram no Japão com os que retornaram ao Brasil. MÉTODO: Todos os pacientes ambulatoriais atendidos de forma consecutiva nas unidades psiquiátricas no Japão e no Brasil de abril de 1997 a abril de 2000 foram comparados. Os diagnósticos foram realizados por psiquiatras de acordo com a CID-10. Os dados sociodemográficos e os diagnósticos no Brasil e no Japão foram comparados por meio do Teste Qui-Quadrado. RESULTADOS: O grupo que retornou ao Brasil era principalmente de homens, não casados, que viviam sós no Japão, tiveram uma breve estada neste país e foram classificados no grupo de esquizofrenia. O grupo no Japão era principalmente constituído de mulheres, casadas, morando com familiares ou amigos, estada longa no Japão e foram classificadas no grupo de ansiedade. A regressão logística mostrou que os fatores mais significativamente associados com o grupo que retornou foram o fato de morar sós e ficarem pouco tempo no Japão (OR = 0,93 e 40,21, respectivamente). CONCLUSÃO: Concluímos que morar em família e ter uma rede de amigos é muito importante para a saúde mental no contexto avaliado