2,453 research outputs found

    Beyond Dexamethasone, Emerging Immuno-Thrombotic Therapies for COVID-19

    Get PDF
    Host immunity is required to clear SARS‐CoV‐2, and inability to clear the virus because of host or pathogen factors renders those infected at risk of poor outcomes. Estimates of those who are able to clear the virus with asymptomatic or paucisymptomatic COVID‐19 remain unclear, and dependent on widespread testing. However, evidence is emerging that in severe cases, pathological mechanisms of hyperinflammation and coagulopathy ensue, the former supported by results from the RECOVERY trial demonstrating a reduction in mortality with dexamethasone in advanced COVID‐19. It remains unclear whether these pathogenic pathways are secondary to a failure to clear the virus because of maladaptive immune responses or if these are sequential COVID‐19 defining illnesses. Understanding the pathophysiological mechanisms underpinning these cascades is essential to formulating rationale therapeutic approaches beyond the use of dexamethasone. Here, we review the pathophysiology thought to underlie COVID‐19 with clinical correlates and the current therapeutic approaches being investigated

    On the Thermodynamics and Experimental Control of Twinning in Metal Nanocrystals

    Get PDF
    International audienceThis work demonstrates a new strategy for controlling the evolution of twin defects in metal nanocrystals by simply following thermodynamic principles. With Ag nanocrystals supported on amorphous SiO2 as a typical example, we establish that twin defects can be rationally generated by equilibrating nanoparticles of different sizes through heating and then cooling. We validate that Ag nanocrystals with icosahedral, decahedral, and single‐crystal structures are favored at sizes below 7 nm, between 7 and 11 nm, and greater than 11 nm, respectively. This trend is then rationalized by computational studies based on density functional theory and molecular dynamics, which show that the excess free energy for the three equilibrium structures correlate strongly with particle size. This work not only highlights the importance of thermodynamic control but also adds another synthetic method to the ever‐expanding toolbox used for generating metal nanocrystals with desired properties.

    Turbine research package for research and development of high performance turboalternator Final report

    Get PDF
    Two-stage, axial flow turbine test rig for providing cold flow aerodynamic performance data on Brayton cycle alternator drive turbin

    Turbine research package for research and development of high performance axial flow turbine-compressor Final report

    Get PDF
    Turbine research package for research and development of high performance axial flow turbine compresso

    Implementation of a herd management system with wireless sensor networks

    Get PDF
    This paper investigates an adaptation of Wireless Sensor Networks (WSNs) to cattle monitoring applications. The proposed solution facilitates the requirement for continuously assessing the condition of individual animals, aggregating and reporting this data to the farm manager. There are several existing approaches to achieving animal monitoring, ranging from using a store and forward mechanism to employing GSM-based techniques; these approaches only provide sporadic information and introduce a considerable cost in staffing and physical hardware. The core of this study is to overcome the aforementioned drawbacks by using alternative cheap, low power consumption sensor nodes capable of providing real-time communication at a reasonable hardware cost. In this paper, both the hardware and software has been designed to provide a solution which can obtain real-time data from dairy cattle whilst conforming to the limitations associated with WSNs implementations

    Formazanate Complexes of Hypervalent Group‐14 Elements as Precursors to Electronically Stabilized Radicals

    Get PDF
    The stability of molecular radicals containing main‐group elements usually hinges on the presence of bulky substituents that shield the reactive radical center. We describe a family of group‐14 formazanate complexes whose chemical reduction allows access to radicals that are stabilized instead by geometric and electron‐delocalization effects, specifically by the square‐pyramidal geometry adopted by the group‐14 atom (Si, Ge, Sn) within the framework of the heteroatom‐rich formazanate ligands. The reduction potentials of the Si, Ge, and Sn complexes as determined by cyclic voltammetry become more negative in that order. Examination of the solid‐state structures of these complexes suggested that their electron‐accepting ability decreases with increasing group‐14 atom size because a larger central atom increases the nonplanarity of the ligand‐based conjugated π‐electron system of the complex. The experimental findings were supported by density‐functional calculations on the parent complexes and the corresponding radicals
    • 

    corecore