10,336 research outputs found
Technology transfer - A selected bibliography
Selected bibliography on technology transfe
Alcohol: taking a population perspective
Alcohol consumption is a global phenomenon, as is the resultant health, social and economic harm. The nature of these harms varies with different drinking patterns and with the societal and political responses to the burden of harm; nevertheless, alcohol-related chronic diseases have a major effect on health. Strong evidence exists for the effectiveness of different strategies to minimize this damage and those policies that target price, availability and marketing of alcohol come out best, whereas those using education and information are much less effective. However, these policies can be portrayed as anti-libertarian and so viewing them in the context of alcohol-related harm to those other than the drinker, such as the most vulnerable in society, is important. When this strategy is successful, as in Scotland, it has been possible to pass strong and effective legislation, such as for a minimum unit price for alcohol
Inhibition of oncogenic transcription factor REL by the natural product derivative calafianin monomer 101 induces proliferation arrest and apoptosis in human B-lymphoma cell lines
Increased activity of transcription factor NF-κB has been implicated in many B-cell lymphomas. We investigated effects of synthetic compound calafianin monomer (CM101) on biochemical and biological properties of NF-κB. In human 293 cells, CM101 selectively inhibited DNA binding by overexpressed NF-κB subunits REL (human c-Rel) and p65 as compared to NF-κB p50, and inhibition of REL and p65 DNA binding by CM101 required a conserved cysteine residue. CM101 also inhibited DNA binding by REL in human B-lymphoma cell lines, and the sensitivity of several B-lymphoma cell lines to CM101-induced proliferation arrest and apoptosis correlated with levels of cellular and nuclear REL. CM101 treatment induced both phosphorylation and decreased expression of anti-apoptotic protein Bcl-XL, a REL target gene product, in sensitive B-lymphoma cell lines. Ectopic expression of Bcl-XL protected SUDHL-2 B-lymphoma cells against CM101-induced apoptosis, and overexpression of a transforming mutant of REL decreased the sensitivity of BJAB B-lymphoma cells to CM101-induced apoptosis. Lipopolysaccharide-induced activation of NF-κB signaling upstream components occurred in RAW264.7 macrophages at CM101 concentrations that blocked NF-κB DNA binding. Direct inhibitors of REL may be useful for treating B-cell lymphomas in which REL is active, and may inhibit B-lymphoma cell growth at doses that do not affect some immune-related responses in normal cells.R01 GM094551 - NIGMS NIH HHS; P50 GM067041 - NIGMS NIH HHS; GM094551 - NIGMS NIH HHS; R24 GM111625 - NIGMS NIH HHS; GM067041 - NIGMS NIH HH
Advanced propellant management system for spacecraft propulsion systems. Phase 1 - Survey study and evaluation
Apollo spacecraft propulsion system propellant managemen
The Tamm-Dancoff Approximation as the boson limit of the Richardson-Gaudin equations for pairing
A connection is made between the exact eigen states of the BCS Hamiltonian
and the predictions made by the Tamm-Dancoff Approximation. This connection is
made by means of a parametrised algebra, which gives the exact quasi-spin
algebra in one limit of the parameter and the Heisenberg-Weyl algebra in the
other. Using this algebra to construct the Bethe Ansatz solution of the BCS
Hamiltonian, we obtain parametrised Richardson-Gaudin equations, leading to the
secular equation of the Tamm-Dancoff Approximation in the bosonic limit. An
example is discussed in depth.Comment: Submitted to the proceedings of the Group28 conference
(Newcastle-upon-Tyne, UK). Journal of Physics: Conference Serie
Evaluating an unconfined aquifer by analysis of age-dating tracers in stream water
The mean transit time (MTT) is a fundamental property of a groundwater flow system that is strongly related to the ratio of recharge rate to storage volume. However, obtaining samples for estimating the MTT using environmental tracers is problematic as flow-weighted samples over the full spectrum of transit times are needed. Samples collected fromthe base flow of a gaining stream in the North Carolina Coastal Plain (West Bear Creek) that were corrected for exchange with the atmosphere yielded environmental tracer concentrations (SF6 and CFC-11) very similar to flow-weighted values from nine or ten streambed piezometers that directly sampled groundwater during low streamflow. At higher streamflow on the falling limb of the hydrograph, stream tracer concentrations (after correction for gas exchange) were significantly higher than the flow-weighted mean from piezometers, consistent with dominance of the streamtracer signal by transient influx of surface water and/or younger subsurface water. The apparent MTT derived from SF6 in low flow stream water samples was 26 years, suggesting a groundwater recharge rate of about 210 mm/yr, that is consistent with vertical profiles obtained by sampling nested piezometers in the aquifer. When sampled under low flow conditions when streamflow consists of a high component of groundwater discharge, West Bear Creek appears to act as a flow-weighted integrator of transit times and, streamflow samples can provide fundamental information regarding groundwater recharge rate and MTT. Our study suggests that watershed-scale evaluation of some groundwater flow systems is possible without utilizing monitoring wells
Modeling the elastic deformation of polymer crusts formed by sessile droplet evaporation
Evaporating droplets of polymer or colloid solution may produce a glassy
crust at the liquid-vapour interface, which subsequently deforms as an elastic
shell. For sessile droplets, the known radial outward flow of solvent is
expected to generate crusts that are thicker near the pinned contact line than
the apex. Here we investigate, by non-linear quasi-static simulation and
scaling analysis, the deformation mode and stability properties of elastic caps
with a non-uniform thickness profile. By suitably scaling the mean thickness
and the contact angle between crust and substrate, we find data collapse onto a
master curve for both buckling pressure and deformation mode, thus allowing us
to predict when the deformed shape is a dimple, mexican hat, and so on. This
master curve is parameterised by a dimensionless measure of the non-uniformity
of the shell. We also speculate on how overlapping timescales for gelation and
deformation may alter our findings.Comment: 8 pages, 7 figs. Some extra clarification of a few points, and minor
corrections. To appear in Phys. Rev.
The Absence of Extra-Tidal Structure in the Sculptor Dwarf Spheroidal Galaxy
The results of a wide-field survey of the Sculptor dwarf spheroidal galaxy
are presented. Our aims were to obtain an accurate map of the outer structure
of Sculptor, and to determine the level of interaction between this system and
the Galaxy. Photometry was obtained in two colours down to the magnitude limits
of V=20 and I=19, covering a 3.1 times 3.1 square deg area centred on Sculptor.
The resulting colour-magnitude data were used as a mask to select candidate
horizontal branch and red giant branch stars for this system. Previous work has
shown that the red horizontal branch (HB) stars are more concentrated than the
blue HB stars. We have determined the radial distributions of these two
populations and show that the overall Sculptor density profile is well
described by a two component model based on a combination of these radial
distributions. Additionally, spectra of the Ca ii triplet region were obtained
for over 700 candidate red giant stars over the 10 square deg region using the
2dF instrument on the Anglo-Australian Telescope. These spectra were used to
remove foreground Galactic stars based on radial velocity and Ca ii triplet
strength. The final list of Sculptor members contained 148 stars, seven of
which are located beyond the nominal tidal radius. Both the photometric and
spectroscopic datasets indicate no significant extra-tidal structure. These
results support at most a mild level of interaction between this system and the
Galaxy, and we have measured an upper mass limit for extra-tidal material to be
2.3 +/- 0.6% of the Sculptor luminous mass. This lack of tidal interaction
indicates that previous velocity dispersion measurements (and hence the amount
of dark matter detected) in this system are not strongly influenced by the
Galactic tidal field.Comment: 53 pages, 23 figures. Accepted for publication in the Astronomical
Journal. Some figures are reduced in size, and a full version is available
at: ftp://ftp.mso.anu.edu.au/pub/coleman/sculptor.pd
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