British foreign policy and the 2015 general election: Consensus on the continuity of a confused vision

In place of a unifying foreign policy strategy or agenda, the main parties head into the general election with little to differentiate them and with little sense of long-term vision, writes Jonathan Gilmore. The main parties seem united in seeing an expanding horizon for a prosperous, globally influential Britain – a responsible, humane and internationalist power – but one which is also simultaneously resigned to more modest ambitions and the narrowing of its actual capacity

Preferential attachment during the evolution of a potential energy landscape

It has previously been shown that the network of connected minima on a potential energy landscape is scale-free, and that this reflects a power-law distribution for the areas of the basins of attraction surrounding the minima. Here, we set out to understand more about the physical origins of these puzzling properties by examining how the potential energy landscape of a 13-atom cluster evolves with the range of the potential. In particular, on decreasing the range of the potential the number of stationary points increases and thus the landscape becomes rougher and the network gets larger. Thus, we are able to follow the evolution of the potential energy landscape from one with just a single minimum to a complex landscape with many minima and a scale-free pattern of connections. We find that during this growth process, new edges in the network of connected minima preferentially attach to more highly-connected minima, thus leading to the scale-free character. Furthermore, minima that appear when the range of the potential is shorter and the network is larger have smaller basins of attraction. As there are many of these smaller basins because the network grows exponentially, the observed growth process thus also gives rise to a power-law distribution for the hyperareas of the basins.Comment: 10 pages, 10 figure

The role of Jupiter in driving Earth’s orbital evolution: an update

In the coming decades, the discovery of the first truly Earth-like exoplanets is anticipated. The characterisation of those planets will play a vital role in determining which are chosen as targets for the search for life beyond the Solar system. One of the many variables that will be considered in that characterisation and selection process is the nature of the potential climatic variability of the exoEarths in question. In our own Solar system, the Earth’s long-term climate is driven by several factors – including the modifying influence of life on our atmosphere, and the temporal evolution of Solar luminosity. The gravitational influence of the other planets in our Solar system add an extra complication – driving the Milankovitch cycles that are thought to have caused the ongoing series of glacial and interglacial periods that have dominated Earth’s climate for the past few million years. Here, we present the results of a large suite of dynamical simulations that investigate the influence of the giant planet Jupiter on the Earth’s Milankovitch cycles. If Jupiter was located on a different orbit, we find that the long-term variability of Earth’s orbit would be significantly different. Our results illustrate how small differences in the architecture of planetary systems can result in marked changes in the potential habitability of the planets therein, and are an important first step in developing a means to characterise the nature of climate variability on planets beyond our Solar system

Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development

In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes. TLRs also have roles in development in many species. The sea anemone Nematostella vectensis is a useful cnidarian model to study the origins of TLR signaling because its genome encodes a single TLR and homologs of many downstream signaling components, including the NF-κB pathway. We have characterized the single N. vectensis TLR (Nv-TLR) and demonstrated that it can activate canonical NF-κB signaling in human cells. Furthermore, we show that the intracellular Toll/IL-1 receptor (TIR) domain of Nv-TLR can interact with the human TLR adapter proteins MAL and MYD88. We demonstrate that the coral pathogen Vibrio coralliilyticus causes a rapidly lethal disease in N. vectensis and that heat-inactivated V. coralliilyticus and bacterial flagellin can activate a reconstituted Nv-TLR–to–NF-κB pathway in human cells. By immunostaining of anemones, we show that Nv-TLR is expressed in a subset of cnidocytes and that many of these Nv-TLR–expressing cells also express Nv-NF-κB. Additionally, the nematosome, which is a Nematostella-specific multicellular structure, expresses Nv-TLR and many innate immune pathway homologs and can engulf V. coralliilyticus. Morpholino knockdown indicates that Nv-TLR also has an essential role during early embryonic development. Our characterization of this primitive TLR and identification of a bacterial pathogen for N. vectensis reveal ancient TLR functions and provide a model for studying the molecular basis of cnidarian disease and immunity.IOS-1354935 - National Science Foundation (NSF); GRFP - National Science Foundation (NSF); GRFP - National Science Foundation (NSF); 1262934 - National Science Foundation (NSF); 2014-BSP - Arnold and Mabel Beckman Foundatio

Astrometric Effects of Gravitational Wave Backgrounds with non-Luminal Propagation Speeds

A passing gravitational wave causes a deflection in the apparent astrometric positions of distant stars. The effect of the speed of the gravitational wave on this astrometric shift is discussed. A stochastic background of gravitational waves would result in a pattern of astrometric deflections which are correlated on large angular scales. These correlations are quantified and investigated for backgrounds of gravitational waves with sub- and super-luminal group velocities. The statistical properties of the correlations are depicted in two equivalent and related ways: as correlation curves and as angular power spectra. Sub-(super-)luminal gravitational wave backgrounds have the effect of enhancing (suppressing) the power in low-order angular modes. Analytical representations of the redshift-redshift and redshift-astrometry correlations are also derived. The potential for using this effect for constraining the speed of gravity is discussed.ER

American Geriatrics Society and National Institute on Aging Bench-to-Bedside conference: sensory impairment and cognitive decline in older adults

This article summarizes the presentations and recommendations of the tenth annual American Geriatrics Society and National Institute on Aging Bench‐to‐Bedside research conference, “Sensory Impairment and Cognitive Decline,” on October 2–3, 2017, in Bethesda, Maryland. The risk of impairment in hearing, vision, and other senses increases with age, and almost 15% of individuals aged 70 and older have dementia. As the number of older adults increases, sensory and cognitive impairments will affect a growing proportion of the population. To limit its scope, this conference focused on sensory impairments affecting vision and hearing. Comorbid vision, hearing, and cognitive impairments in older adults are more common than would be expected by chance alone, suggesting that some common mechanisms might affect these neurological systems. This workshop explored the mechanisms and consequences of comorbid vision, hearing, and cognitive impairment in older adults; effects of sensory loss on the aging brain; and bench‐to‐bedside innovations and research opportunities. Presenters and participants identified many research gaps and questions; the top priorities fell into 3 themes: mechanisms, measurement, and interventions. The workshop delineated specific research questions that provide opportunities to improve outcomes in this growing population.Funding was provided by National Institutes of Health (NIH) Grant U13 AG054139-01. Dr. Whitson's efforts and contributions were supported by R01AG043438, R24AG045050, UH2AG056925, and 5P30AG028716. Dr. Lin's effort and contributions were also supported by R01AG055426, R01HL096812, and R33DC015062. (U13 AG054139-01 - National Institutes of Health (NIH); R01AG043438; R24AG045050; UH2AG056925; 5P30AG028716; R01AG055426; R01HL096812; R33DC015062)Accepted manuscrip