Client/server models for transparent, distributed computational resources

Client/server models are proposed to address issues of shared resources in a distributed, heterogeneous UNIX environment. Recent development of automated Remote Procedure Call (RPC) interface generator has simplified the development of client/server models. Previously, implementation of the models was only possible at the UNIX socket level. An overview of RPCs and the interface generator will be presented and will include a discussion of generation and installation of remote services, the RPC paradigm, and the three levels of RPC programming. Two applications, the Nuclear Plant Analyzer (NPA) and a fluids simulation using molecular modelling, will be presented to demonstrate how client/server models using RPCs and External Data Representations (XDR) have been used production/computation situations. The NPA incorporates a client/server interface for transferring/translation of TRAC or RELAP results from the UNICOS Cray to a UNIX workstation. The fluids simulation program utilizes the client/server model to access the Cray via a single function allowing it to become a shared co-processor to the workstation application. 5 refs., 6 figs

Client/Server distributed processing using SunOS remote procedure protocol

Over the last ten years the development of PC's and workstations has changed the way computing is performed. Previously, extensive computations were performed on large high speed mainframe machines with substantial storage capacity. Large capital and operational costs were associated with these machines. The advent of more powerful workstations has brought more computational cycles to the users at lower cost than was achieved with busy timesharing systems. However, many users still can't afford individual special purpose hardware or gigabytes of storage. A successful distributed processing environment must share these resources. Client/Server models have been proposed to address the issues of shared resources. They are not a new idea, but their implementation has been difficult. With the introduction of SUN's public domain Remote Procedure Call (RPC) Protocol and SUN's interface generator, RPCGEN, their implementation has been made easier. SUN has developed a set of C'' callable routines that handle the Client/Server operations. The availability of Network File System (NFS) on the SRL CRAY and the arrival of Wollongong's latest version of NFS has allowed applications and information sharing between computing platforms. This paper reviews the Client/Server model with respect to SUN's RPC implementation. The discussion will focus on the RPC connection between local and remote machines, the RPC Paradigm for making remote procedure calls, and the programming levels of the RPC libraries. The paper will conclude with summaries of two applications developed at SRL using the protocol and their effect on our computing environment. These include the Nuclear Plant Analyzer and an animation of fluids using behavioral simulation of atom-like particles

Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin E2 Signaling

Annually, >600,000 new cases of head and neck cancer (HNC) are diagnosed worldwide with primary treatment being surgery and radiotherapy. During ionizing radiation (IR) treatment of HNC, healthy salivary glands are collaterally damaged, leading to loss of function that severely diminishes the quality of life for patients due to increased health complications, including oral infections and sores, cavities, and malnutrition, among others. Therapies for salivary hypofunction are ineffective and largely palliative, indicating a need for further research to uncover effective approaches to prevent or restore loss of salivary gland function following radiotherapy. Previous work in our lab implicated prostaglandin E2 (PGE2) as an inflammatory mediator whose release from radiation-exposed cells promotes salivary gland damage and loss of function. Deletion of the P2X7 purinergic receptor for extracellular ATP reduces PGE2 secretion in irradiated primary parotid gland cells, and salivary gland function is enhanced in irradiated P2X7R–/– mice compared to wild-type mice. However, the role of PGE2 signaling in irradiated salivary glands is unclear and understanding the mechanism of PGE2 action is a goal of this study. Results show that treatment of irradiated mice with the non-steroidal anti-inflammatory drug (NSAID) indomethacin, which reduces PGE2 production via inhibition of cyclooxygenase-1 (COX-1), improves salivary gland function compared to irradiated vehicle-treated mice. To define the signaling pathway whereby PGE2 induces salivary gland dysfunction, primary parotid gland cells treated with PGE2 have increased c-Jun N-terminal Kinase (JNK) activation and cell proliferation and reduced amylase levels and store-operated calcium entry (SOCE). The in vivo effects of blocking PGE2 production were also examined and irradiated mice receiving indomethacin injections have reduced JNK activity at 8 days post-irradiation and reduced proliferation and increased amylase levels at day 30, as compared to irradiated mice without indomethacin. Combined, these data suggest a mechanism whereby irradiation-induced PGE2 signaling to JNK blocks critical steps in saliva secretion manifested by a decrease in the quality (diminished amylase) and quantity (loss of calcium channel activity) of saliva, that can be restored with indomethacin. These findings encourage further attempts evaluating indomethacin as a viable therapeutic option to prevent damage to salivary glands caused by irradiation of HNC in humans. © Copyright © 2021 Gilman, Camden, Woods, Weisman and Limesand.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Testing theories of mire development using multiple successions at Crymlyn Bog, West Glamorgan, South Wales, UK

1 Direct observations of long-term plant succession can be made using quantified plant macrofossil records from peat bogs, providing a means to re-evaluate theories of succession previously based on time-space substitution studies or field stratigraphic surveys. 2 Multiple successions from fen towards raised mire recorded at Crymlyn Bog demonstrate that divergent pathways exist, even when initial conditions are similar within a single bog. 3 Over time-scales relevant to the later stages of mire succession, allogenic forcing factors are significant and may be responsible for driving the direction and rate of species turnover in both forward and reversed hydroseral successions. 4 Differences in the local climatic regime may be responsible for the contrasting character of the mid- and late-Holocene transitional mire communities represented in Core CRB93 at Crymlyn Bog. 5 Plant macrofossil analyses show that Sphagnum is not always a dominant part of the mire community before the establishment of raised peats. Other species including Eriophorum vaginatum, may be equally important 'ecosystem engineers' at the fen–bog transition

Sulfonamidas em leite por cromatografia líquida de alta eficiência com derivação pré-coluna e detecção por fluorescência Sulfonamides in milk by high performance liquid chromatography with pre-column derivatization and fluorescence detection

O objetivo deste trabalho foi avaliar e validar um método para deteminação de resíduos de sulfatiazol (STZ), sulfametazina (SMZ) e sulfadimetoxina (SDM) em leite UHT integral. A extração foi realizada com diclorometano e coluna de extração em fase sólida de sílica. Os resíduos, após derivação com fluorescamina, foram quantificados por cromatografia líquida de alta eficiência com detector de fluorescência. O limite de detecção das três sulfas em amostra de leite integral foi 0,3 µg L-1 e o limite de quantificação foi 1 µg L-1 para STZ e SMZ e 2,5 µg L-1 para SDM, com coeficientes de variação entre 4,4 e 6,6%. Os valores de recuperação para STZ, SMZ e SDM foram 63,2, 91,2 e 63,2%, respectivamente. Considerando o limite máximo de resíduo estabelecido pela legislação brasileira de 100 µg kg-1 para a soma das concentrações totais de STZ, SMZ e SDM, o método descrito permite a determinação simultânea dos três analitos em amostras de leite UTH integral.<br>The objective of this work was to evaluate and validate a method for analysis of sulfathiazole (STZ), sulfamethazine (SMZ) and sulfadimethoxine (SDM) residues in milk. Extraction was carried out with diclhoromethane followed by silica solid phase extraction. The extracts were derivatizated with fluorescamine and quantified by reversed-phase high performance liquid chromatography with fluorescence detection. The detection limit for the three sulfonamides was 0.3 µg L-1 and the quantification limit was 1 µg L-1 for STZ and SMZ and 2.5 µg L-1 for SDM, with coefficient of variation ranging from 4.4 to 6.6%. The recoveries for STZ, SMZ and SDM were 63.2, 91.2 and 63.2%, respectively. Considering that Brazilian regulation sets maximum residue limit in milk of 100 µg kg-1 for total sulfonamide concentrations (STZ, SMZ and SDM), the present method is adequate to quantify the residues of three sulfonamides simultaneously in UHT milk

Gas Transfer at Water Surfaces 2010

PrefaceSection 1: Interfacial Turbulence and Air-Water Scalar TransferJ. Hunt, S. Belcher, D. Stretch, S. Sajjadi, J. Clegg [1]S.A. Kitaigorodskii [13]S.A. Kitaigorodskii [29]Y. Toba [38]D. Turney, S. Banerjee [51]J.G. Janzen, H.E. Schulz, G.H. Jirka [65]S. Komori, R. Kurose, N. Takagaki, S. Ohtsubo, K. Iwano, K. Handa, S. Shimada [78]J. Beya, W. Peirson, M. Banner [90]S. Mizuno [104]M. Sanjou, I. Nezu, A. Toda [119]M. Sanjou, I. Nezu, Y. Akiya [129]K. Takehara, Y. Takano, T.G. Etoh [138]G. Caulliez [151]Section 2: Numerical Studies on Interfacial Turbulence and Scalar TransferL.-P. Hung, C.S. Garbe, W.-T. Tsai [165]A. E. Tejada-Martínez, C. Akan, C.E. Grosch [177]W.-T. Tsai, L.-P. Hung [193]P.G. Jayathilake, B.C. Khoo, Zhijun Tan [200]H.E. Schulz, A.L.A. Simões, J.G. Janzen [208]Section 3: Bubble-Mediated Scalar TransferD.P. Nicholson, S.R. Emerson, S. Khatiwala, R.C. Hamme [223]W. Mischler, R. Rocholz, B. Jähne [238]R. Patro, I. Leifer [249]K. Loh, K.B. Cheong, R. Uittenbogaard [262]N. Mori, S. Nakagawa [273]Section 4: Effects of Surfactants and Molecular Diffusivity on Turbulence and Scalar TransferA. Soloviev, S. Matt, M. Gilman, H. Hühnerfuss, B. Haus, D. Jeong, I. Savelyev, M. Donelan [285]S. Matt, A. Fujimura, A. Soloviev, S.H. Rhee [299]P. Vlahos, E.C. Monahan, B.J.Huebert, J.B. Edson [313]K.E. Richter, B. Jähne [322]X. Yan, W.L. Peirson, J.W. Walker, M.L. Banner [333]Section 5: Field MeasurementsP.M. Orton, C.J. Zappa, W.R. McGillis [343]U.Schimpf, L. Nagel, B. Jähne [358]C.L. McNeil, E.A. D'Asaro, J.A. Nystuen [368]D. Turk, B. Petelin, J.W. Book [377]M. Ribas-Ribas, A. Gómez-Parra, J.M. Forja [394]A. Rutgersson, A.-S. Smedman, E. Sahlée [406]H. Pettersson, K. K. Kahma, A. Rutgersson, M. Perttilä [420]Section 6: Global Air-Sea CO2 FluxesR. Wanninkhof, G.-H. Park, D.B. Chelton, C.M. Risien [431]N. Suzuki, S. Komori, M.A. Donelan [445]Y. Suzuki, Y. Toba [452]M.T. Johnson, C. Hughes, T.G. Bell, P.S. Liss [464]Section 7: Advanced Measuring TechniquesO. Tsukamoto, F. Kondo [485]R. Rocholz, S. Wanner, U. Schimpf, B. Jähne [496]B.C.G. Gonzalez, A.W. Lamon, J.G. Janzen, J.R. Campos, H.E. Schulz [507]E. Sahlée, K. Kahma, H. Pettersson, W.M. Drennan [516]D. Kiefhaber, R. Rocholz, G. Balschbach, B. Jähne [524]C.S. Garbe, A. Heinlein [535]Section 8: Environmental Problems Related to Air-Water Scalar TransferW.L. Peirson, G.A. Lee, C. Waite, P. Onesemo, G. Ninaus [545]Y.J. Choi, A. Abe, K. Takahashi [559]Y. Baba, K. Takahashi [571]R. Onishi, K. Takahashi, S. Komori [582][593]Turbulence and wave dynamics across gas-liquid interfacesThe calculation of the gas transfer between the ocean and atmosphereThe influence of wind wave breaking on the dissipation of the turbulent kinetic energy in the upper ocean and its dependence on the stage of wind wave developmentMarvellous self-consistency inherent in wind waves : Its origin and some items related to air-sea transfersNear surface turbulence and its relationship to air-water gas transfer ratesTurbulent gas flux measurements near the air-water interface in an oscillating-grid tankSensible and latent heat transfer across the air-water interface in wind-driven turbulenceRainfall-generated, near-surface turbulenceEffects of the mechanical wave propagating in the wind direction on currents and stresses across the air-water interfaceTurbulent transport in closed basin with wind-induced water wavesPIV measurements of Langumuir circulation generated by wind-induced water wavesStudy of vortices near wind wave surfaces using high-speed video camera and MLSWind wave breaking from micro to macroscaleValidation of Eddy-renewal model by numerical simulationMass transfer at the surface in LES of wind-driven shallow water flow with Langmuir circulationCharacteristics of gas-flux density distribution at the water surfacesNumerical simulation of interfacial mass transfer using the immersed interface methodStatistical approximations in gas-liquid mass transferAn inverse approach to estimate bubble-mediated air-sea gas flux from inert gas measurementsExperimental setup for the investigation of bubble mediated gas exchangeGas transfer velocity of single CO2 bubblesMass transfer across single bubblesAeration of surf zone breaking wavesModification of turbulence at the air-sea interface due to the presence of surfactants and implications for gas exchange. Part I: laboratory experimentModification of turbulence at the air-sea interface due to the presence of surfactants and implications for gas exchange. Part II: numerical simulationsWind-dependence of DMS transfer velocity: Comparison of model with recent southern ocean observationsA laboratory study of the Schmidt number dependency of air-water gas transferOn transitions in the Schmidt number dependency of low solubility gas transfer across air-water interfacesAn autonomous self-orienting catamaran (SOCa) for measuring air-water fluxes and forcingThe 2009 SOPRAN active thermography pilot experiment in the Baltic SeaObservations of air-sea exchange of N2 and O2 during the passage of Hurricane Gustav in the Gulf of Mexico during 2008The effect of high wind Bora events on water pCO2 and CO2 exchange in the coastal Northern AdriaticSeasonal sea-surface CO2 fugacity in the north-eastern shelf of the Gulf of Cádiz (southwest Iberian Peninsula)Including mixed layer convection when determining air-sea CO2 transfer velocityAir-sea carbon dioxide exchange during upwellingImpact of small-scale variability on air-sea CO2 fluxesThe effect of wind variability on the air-sea CO2 gas flux estimationFuture global mapping of air-sea CO2 flux by using wind and wind-wave distribution of CMIP3 multi-model ensembleA Rumsfeldian analysis of uncertainty in air-sea gas exchangeAccurate measurement of air-sea CO2 flux with open-path Eddy-CovarianceCombined Visualization of wind waves and water surface temperatureMicroscopic sensors for oxygen measurement at air-water interfaces and sediment biofilmsDamping of humidity fluctuations in a closed-path systemImproved Optical Instrument for the Measurement of Water Wave Statistics in the FieldFriction Velocity from Active Thermography and Shape AnalysisEvaporation mitigation by storage in rock and sandDevelopment of oil-spill simulation system based on the global ocean-atmosphere modelStructure variation dependence of tropical squall line on the tracer advection scheme in cloud-resolving modelHigh-resolution simulations for turbulent clouds developing over the oceAuthor Inde