Restricted feedback control of one-dimensional maps

Dynamical control of biological systems is often restricted by the practical constraint of unidirectional parameter perturbations. We show that such a restriction introduces surprising complexity to the stability of one-dimensional map systems and can actually improve controllability. We present experimental cardiac control results that support these analyses. Finally, we develop new control algorithms that exploit the structure of the restricted-control stability zones to automatically adapt the control feedback parameter and thereby achieve improved robustness to noise and drifting system parameters.Comment: 29 pages, 9 embedded figure

From Extractivism to Global Extractivism : The Evolution of an Organizing Concept

All the named authors were members of the Helsinki Research Working Group on Global Extractivisms and Alternatives, who jointly constructed this article. Equal authorship by all authors is recognised.Research on extractivism has rapidly proliferated, expanding into new empirical and conceptual spaces. We examine the origins, evolution, and conceptual expansion of the concept. Extractivism is useful to analyze resource extraction practices around the world. ‘Global Extractivism’ is a new conceptual tool for assessing global phenomena. We situate extractivism within an ensemble of concepts, and explore its relation to development, the state, and value. Extractivism as an organizing concept addresses many fields of research. Extractivism forms a complex of self-reinforcing practices, mentalities, and power differentials underwriting and rationalizing socio-ecologically destructive modes of organizing life-through subjugation, depletion, and non-reciprocity.Peer reviewe

വളപ്പ് മത്സ്യകൃഷി

വളപ്പ് മത്സ്യകൃഷിയിൽ ജലാശയത്തിൻ്റെ അടിത്തട്ട് ഒഴികെ എല്ലാ വശങ്ങളും അടച്ച് ജലത്തിൽ മത്സ്യം വളർത്തി, ഒരു വശത്ത് നിന്നെങ്കിലും ജലം സ്വതന്ത്രമായി ഒഴുകാൻ അനുവദിക്കുന്നു ജലാശയത്തിൻ്റെ വളപ്പിൻ്റെ അടിഭാഗമായി രൂപപ്പെടുന്നു.ഇത്തരത്തിലുള്ള മത്സ്യകൃഷി സമ്പ്രദായത്തെ കുളങ്ങളിലെ മത്സ്യകൃഷിയുടെയും കൂട് മത്സ്യകൃഷിയ ടെയും സങ്കരയിനമായി കണക്കാക്കാം. അവ സാധാരണയായി തടാകങ്ങളുടെയും ജലസംഭരണിയുടെയും തീരങ്ങൾ ഉൾപ്പെടെയുള്ള ജലാശയങ്ങളുടെ ആഴം കുറഞ്ഞ പ്രദേശങ്ങളിലാണ് നിർമ്മിക്കുക. വളപ്പിന്റെ ആകൃതി, ജലാശയത്തിന്റെ ആഴം, തീരത്തിന്റെയും കരയുടെയും സ്വഭാവം എന്നിവ അനുസരിച്ച് ചതുരാകൃതിയിലോ, ദീർഘചതുരാകൃതിയിലോ, ദീർഘവൃത്താകൃതിയിലോ, നീളമേറിയതോ, കുതിരലാടാകൃതിയിലോ ആയിരിക്കും

Pen Culture

Pen culture is defined as the raising of fish in a volume of water enclosed on all sides except the bottom, permitting the free circulation of water at least from one side. The bottom of the water body forms the bottom of the pen. This system can be considered a hybrid between pond culture and cage culture. They are usually constructed along the shallow regions of potential water bodies including the banks of the lakes as well as reservoirs

Biobanking and consenting to research: a qualitative thematic analysis of young people’s perspectives in the North East of England

Background: Biobanking biospecimens and consent are common practice in paediatric research. We need to explore children and young people’s (CYP) knowledge and perspectives around the use of and consent to biobanking. This will ensure meaningful informed consent can be obtained and improve current consent procedures. Methods: We designed a survey, in co-production with CYP, collecting demographic data, views on biobanking, and consent using three scenarios: 1) prospective consent, 2) deferred consent, and 3) reconsent and assent at age of capacity. The survey was disseminated via the Young Person’s Advisory Group North England (YPAGne) and participating CYP’s secondary schools. Data were analysed using a qualitative thematic approach by three independent reviewers (including CYP) to identify common themes. Data triangulation occurred independently by a fourth reviewer. Results: One hundred two CYP completed the survey. Most were between 16–18 years (63.7%, N = 65) and female (66.7%, N = 68). 72.3% had no prior knowledge of biobanking (N = 73). Acceptability of prospective consent for biobanking was high (91.2%, N = 93) with common themes: ‘altruism’, ‘potential benefits outweigh individual risk’, 'frugality', and ‘(in)convenience’. Deferred consent was also deemed acceptable in the large majority (84.3%, N = 86), with common themes: ‘altruism’, ‘body integrity’ and ‘sample frugality’. 76.5% preferred to reconsent when cognitively mature enough to give assent (N = 78), even if parental consent was previously in place. 79.2% wanted to be informed if their biobanked biospecimen is reused (N = 80). Conclusion: Prospective and deferred consent acceptability for biobanking is high among CYP in the UK. Altruism, frugality, body integrity, and privacy are the most important themes. Clear communication and justification are paramount to obtain consent. Any CYP with capacity should be part of the consenting procedure, if possible

Britain and globalization

Many perspectives on globalization see it as differentiated in its effects and reception, culturally driven, either pre-modern or post-modern, best captured by globalist or sceptical perspectives, and an equalising phenomenon. This article discusses the British experience of globalization in the light of such approaches and argues that looking at this case gives an alternative view. Six themes on globalization are explored across four areas of the British experience of globalization. It is argued that in Britain globalization is, in contrast to the approaches outlined above, differentiated but also generalising, economically driven, modern, best understood with a mix of globalist and sceptical perspectives and structured by power, inequality and conflict. It is also argued that the British experience of globalization is a specific one and that Britain is a very globalized and globalizing country, economically, culturally and politically

Muslim Integration into Western Cultures: Between Origins and Destinations

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91196/1/j.1467-9248.2012.00951.x.pd

Role of Chaperone Mediated Autophagy (CMA) in the Degradation of Misfolded N-CoR Protein in Non-Small Cell Lung Cancer (NSCLC) Cells

Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells