Strengthening Renal Registries and ESRD Research in Africa

CITATION: Davids, M. R., et al. 2017. Strengthening renal registries and ESRD research in Africa. Seminars in Nephrology, 37(3):211-223, doi:10.1016/j.semnephrol.2017.02.002.The original publication is available at http://www.seminarsinnephrology.orgENGLISH ABSTRACT: In Africa the combination of non-communicable diseases, infectious diseases, exposure to environmental toxins and acute kidney injury related to trauma and childbirth are driving an epidemic of chronic kidney disease (CKD) and end-stage renal disease (ESRD). Good registry data can inform the planning of renal services and can be used to argue for better resource allocation, audit the delivery and quality of care, and monitor the impact of interventions. Few African countries have established renal registries and most have failed due to resource constraints. In this paper we briefly review the burden of CKD and ESRD in Africa then consider the research questions which could be addressed by renal registries. We describe examples of the impact of registry data and summarise the sparse primary literature on country-wide renal replacement therapy (RRT) in African countries over the past 20 years. Finally, we highlight some initiatives and opportunities for strengthening research on ESRD and RRT in Africa. These include the establishment of the African Renal Registry and the availability of new areas for research. We also discuss capacity-building, collaboration, open access publication and the strengthening of local journals, all measures which may improve the quantity, visibility and impact of African research outputs.AFRIKAANSE OPSOMMING: Geen opsomming beskikbaarhttp://www.seminarsinnephrology.org/article/S0270-9295(17)30002-5/fulltextPostprin

Cephazolin and Gentamicin are stable in lactate-buffered Fresenius peritoneal Dialysate for seven days at room temperature

Peritoneal dialysis (PD) peritonitis is a common complication of PD and is associated with significant morbidity and mortality (1). Treatment involves intraperitoneal delivery of antibiotics, which, for this condition, is superior to the intravenous route (2). Outpatient treatment involves loading antibiotics into bags of dialysate, which are then self-administered. However, some patients are unable to load the antibiotics themselves and therefore rely on pre-loaded bags provided to them by health care staff. Treatment for PD peritonitis is usually required for no less than 14 days, and it is desirable to pre-load at least several days’ worth of bags for convenient outpatient therapy (3). That pre-loading in turn depends on the stability of the required antibiotic in solution under conditions of home storage. However, relevant data on antibiotic stability is limited to just some of the available PD solutions and containers (4-7). Guidelines, such as those published by the International Society for Peritoneal Dialysis provide information about the stability and compatibility of various antibiotics in peritoneal dialysate, although they note the limited data for specific PD solutions and suggest the need for further study (3). It has also been suggested by others that data obtained from experiments in one solution or system cannot be extrapolated to another (4). A commonly used PD system is the polyvinyl chloride twin-bagged lactate-buffered glucose-based solution from Fresenius (ANDY-Plus/Disc: Fresenius Medical Care, Bad Homburg, Germany). The stability of antibiotics in this system has not been widely studied and cannot be confirmed by the manufacturer. The aim of the present study was therefore to assess the stability of cephazolin and gentamicin in that dialysate under conditions that simulate up to 7 days of home storage, to ensure effective and convenient use for outpatient treatment of PD peritonitis

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17

Abstract Background: Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities. Methods: We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs. Findings: Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46·3% (95% UI 46·1–46·5) in 2017, compared with 28·7% (28·5–29·0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88·6% (95% UI 87·2–89·7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664–711) of the 1830 (1797–1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76·1% (95% UI 71·6–80·7) of countries from 2000 to 2017, and in 53·9% (50·6–59·6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017. Interpretation: Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation