Generating Homology Relationships by Alignment of Anatomical Ontologies

The anatomy of model species is described in ontologies, which are used to standardize the annotations of experimental data, such as gene expression patterns. To compare such data between species, we aim to establish homology relations between ontologies describing different species. We present a new algorithm, and its implementation in the software Homolonto, to create new relationships between anatomical ontologies, based on the homology concept. These relationships and the Homolonto software are available at "http://bgee.unil.ch/.":http://bgee.unil.ch

I - Matter, antimatter and geometry II - The twin universe model : a solution to the problem of negative energy particles III - The twin universe model plus electric charges and matter-antimatter symmetry

We introduce a new dynamical group whose coadjoint action on its momentum space takes account of matter-antimatter symmetry on pure geometrical grounds. According to this description the energy and the spin are unchanged under matter-antimatter symmetry. We recall that the antichron components of the Poincar\'{e} group, ruling relativistic motions of a mass-point particle, generate negative energy particles. The model with two twin universes, inspired by Sakharov's one, solves the stability issue. Positive and negative energy particles motions hold in two distinct folds. The model is extended to charged particles. As a result, the matter-antimatter duality holds in both universes.Comment: 19 Fevrier 200

Value and Judgment in Investment Treaty Arbitration

Are international treaties consenting to the resolution of disputes between foreign investors and the host states to their investment still a good idea? Recent and not so recent criticism of such treaty provisions calls into question whether investor-state tribunals can act as neutral arbiters of such disputes. This criticism argues that tribunals are biased in favor of the business interests of investors—and therefore disfavor the state’s right to regulate. Responses to this criticism frequently have alleged the opposite: The arbitral tribunals constituted under international treaties are, if anything, too friendly towards the interests of states. They fail to protect the very economic interests of foreign investors that the treaties were designed to promote

The Privacy Principle

Near daily news reports remind us that we live in an intelligence world. The U.S. National Security Agency (NSA) collects terabytes of global communications. Most famously, the NSA\u27s PRISM and UPSTREAM programs intercepted and monitored the global internet-based communications and telephone calls of foreign nationals, as well as those initiated or received by persons outside of the United States

Homolonto: generating homology relationships by pairwise alignment of ontologies and application to vertebrate anatomy

Motivation: The anatomy of model species is described in ontologies, which are used to standardize the annotations of experimental data, such as gene expression patterns. To compare such data between species, we need to establish relations between ontologies describing different species. Results: We present a new algorithm, and its implementation in the software Homolonto, to create new relationships between anatomical ontologies, based on the homology concept. Homolonto uses a supervised ontology alignment approach. Several alignments can be merged, forming homology groups. We also present an algorithm to generate relationships between these homology groups. This has been used to build a multi-species ontology, for the database of gene expression evolution Bgee. Availability: download section of the Bgee website http://bgee.unil.ch/ Contact: [email protected] Supplementary information: Supplementary data are available at Bioinformatics onlin

A fully coupled diffusion-reaction scheme for moisture sorptionedesorption in an anhydride-cured epoxy resin

Thermoset materials frequently display non-classical moisture sorption behaviors. In this paper, we investigated this issue from an experimental point of view as well as in terms of modeling the water transport. We used the gravimetric technique to monitor water uptake by epoxy samples, with several thicknesses exposed to different levels of humidity during absorption and desorption tests. Our results revealed that the polymer displays a two-stage behavior with a residual amount of water that is desorbed progressively. We proposed a phenomenological reaction-diffusion scheme to describe this behavior. The model describes water transport as a competition between diffusion and the reaction, during which the local diffusivity and solubility depend on the local advancement of the reaction. We then implemented our model using COMSOL Multiphysics and identified it using a MATLAB-COMSOL optimization tool and the experimental data. We discussed the relation between the hydrophilicity of the product of the reaction and the diffusion behavior. We examined the reaction-induced modification of the water concentration field. It is worth noting that part of the phenomenology can be explained by the presence of hydrolyzable groups