Transient Changes in Melt Pool Size in Laser Additive Manufacturing Processes

Mechanical Engineerin

An invitation to quantum tomography (II)

The quantum state of a light beam can be represented as an infinite dimensional density matrix or equivalently as a density on the plane called the Wigner function. We describe quantum tomography as an inverse statistical problem in which the state is the unknown parameter and the data is given by results of measurements performed on identical quantum systems. We present consistency results for Pattern Function Projection Estimators as well as for Sieve Maximum Likelihood Estimators for both the density matrix of the quantum state and its Wigner function. Finally we illustrate via simulated data the performance of the estimators. An EM algorithm is proposed for practical implementation. There remain many open problems, e.g. rates of convergence, adaptation, studying other estimators, etc., and a main purpose of the paper is to bring these to the attention of the statistical community.Comment: An earlier version of this paper with more mathematical background but less applied statistical content can be found on arXiv as quant-ph/0303020. An electronic version of the paper with high resolution figures (postscript instead of bitmaps) is available from the authors. v2: added cross-validation results, reference

Detailed temporal structure of communication networks in groups of songbirds

This work was supported by EPSRC Early Career research fellowship EP/L020505/1

Assessing the variation in the load that produces maximal upper-body power

Substantial variation in the load that produces maximal power has been reported. It has been suggested that the variation observed may be due to differences in subject physical characteristics. Therefore the aim of this study was to determine the extent in which anthropometric measures correlate to the load that produces maximal power. Anthropometric measures (upper-arm length, forearm length, total arm length, upper-arm girth) and bench press strength were assessed in 26 professional rugby union players. Peak power was then determined in the bench press throw exercise using loads of 20 to 60% of one repetition maximum (1RM) in the bench press exercise. Maximal power occurred at 30 +/- 14 %1RM (mean +/- SD). Upper-arm length had the highest correlation with the load maximizing power: -0.61 (90% confidence limits -0.35 to -0.78), implying loads of 22 vs. 38 %1RM maximize power for players with typically long vs. short upper-arm length. Correlations for forearm length, total arm length and upper-arm girth to the load that maximized power were -0.29 (0.04 to -0.57), -0.56 (-0.28 to -0.75), and -0.29 (0.04 to -0.57), respectively. The relationship between 1RM and the load that produced maximal power was r = -0.23 (0.10 to -0.52). The between-subject variation in the load that maximised power observed (SD= +/- 14 %1RM) may have been due to differences in anthropometric characteristics, and absolute strength and power outputs. Indeed, athletes with longer limbs and larger girths, and greater maximal strength and power outputs utilised a lower percentage of 1RM loads to achieve maximum power. Therefore, we recommend individual assessment of the load that maximizes power output

Managing the risk of iatrogenic transmission of Creutzfeldt-Jakob disease in the UK.

BACKGROUND: With the emergence of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (CJD) in the UK, there is concern about iatrogenic transmission, and the approach to managing this risk is unique. AIM: To describe and review CJD incident management and the notification of individuals 'at increased risk' as a strategy for reducing iatrogenic transmission. METHODS: A description of iatrogenic CJD transmission, the CJD Incidents Panel's role, the number and nature of CJD incidents reported and the individuals considered 'at increased risk' by mid-2012. FINDINGS: Seventy-seven UK cases of CJD are likely to have resulted from iatrogenic transmission, among recipients of human-derived growth hormone (64 cases), dura mater grafts (eight cases), blood transfusions (four cases) and plasma products (one case). To limit transmission, the Panel reviewed 490 incidents and advised on look-backs, recalls of blood and plasma products, and quarantining and disposing of surgical instruments. Additionally, on Panel advice, around 6000 asymptomatic individuals have been informed they are at increased risk of CJD and have been asked to follow public health precautions. CONCLUSION: The strategy to reduce iatrogenic transmission of CJD has been developed in a context of scientific uncertainty. The rarity of transmission events could indicate that incident-related exposures present negligible transmission risks, or--given the prolonged incubation and subclinical phenotypes of CJD--infections could be yet to occur or have been undetected. Scientific developments, including better estimates of infection prevalence, a screening test, or improvements in decontaminating surgical instruments, may change future risk management

The Best of Both Worlds: Experiences of Co-developing Innovative Undergraduate Health Care Programmes in Egypt

As medical education has become increasingly globalised, universities across the world have sought to raise standards by partnering with well-established institutions and a number of different partnership models have emerged. This article describes an academic collaboration between University College London (UCL), UK, and Newgiza University (NGU), Egypt, to establish modern and innovative undergraduate medicine, dentistry, and pharmacy programmes delivered in Egypt. Academics from UCL and NGU co-developed programmes using established materials, assessments, and processes from the equivalent programmes at UCL. Dedicated project managers, regular steering group meetings, strong working relationships between project teams, and iterative curriculum and assessment development processes were important features of the success of this work. A multidisciplinary first semester included students across all 3 health care programmes. This promoted collaboration between academics at both institutions. Although UCL resources were the basis of this project, the different sociocultural, ethical, professional, and regulatory frameworks in Egypt have meant that a number of adaptations have been necessary, in both curricula and teaching content. Perhaps the most important factor underpinning the success of this project has been the mutual respect and sensitivity of academics and clinicians from both institutions

Suicide and self-harm in Britain: researching risk and resilience using UK surveys

Aim The main aim of this study was to raise awareness of surveys that could be used to inform self-harm and suicide prevention work. We asked: What UK survey datasets are available for research? What aspects of people’s lives are associated with self-harm and attempted suicide? How do statistical findings resonate with people’s lived experience? What implications do they see? Findings Survey analyses revealed that risk factors for self-harm are wide ranging and include: Mental health Physical health and health behaviours Social relationships Stressful events Employment and financial circumstances Identity and demographics Many different factors are independently associated with self-harm. There is a dose relationship, with more exposure to a factor linked with increased risk. Risks are cumulative that is, exposure to multiple factors is associated with greater risk. Through facilitated consultation, men with lived experience, bereaved family members, and practitioners identified recommendations for responding to suicidal distress in men. These related to the following three main areas: 1. Recognising need: who is ‘ill enough’? Permission - men said that they often did not know they were entitled to help Ask - people who outwardly appear to be functioning may not be Persistence - ask and offer help more than once. 2. Facilitating access: right words, time and place What is available - support is needed with ongoing stress as well as for crises Find the words - men wanted examples of how to ask for help Allow time - employers expect recovery to be swift, some men felt rushed to come off medications or were discharged from services they still needed. 3. Adjusting delivery: equal engagement Power - some were uncomfortable with service dynamics, preferring peer support Every service contact counts - negative contacts had particular impact Safe spaces - may be different for men and women. Methods There were three strands of work: Secondary analysis of nine survey series, spanning more than twenty years Linkage of 144,000 survey participants to information on whether they were alive in 2013 and whether they had taken their own life Facilitated consultation, through depth interviews with people with lived experience