Analgesic and Anti-inflammatory Profile of n-Hexane Fraction of Viola betonicifolia

Purpose: To evaluate the analgesic and anti-inflammatory activities of n-hexane extract of the whole plant of Viola betonicifolia Sm, family: Violaceace.Methods: The n-hexane fraction of Viola betonicifolia (VBHF) was tested for its analgesic and antiinflammatory activities (carrageenan-induced and histamine-induced edema models) in BALB/c mice.Results: VBHF exhibited significant (p < 0.01) analgesic and anti-inflammatory activity at test doses of 100, 200 and 300 mg/kg. The analgesic effect of VBHF was dose-dependent in acetic acid pain modelwhile the extract was a weak analgesic at the dose of 300 mg/kg in hot plate and tail immersion test. Diclofenac sodium and tramadol showed better analgesic properties to the extract. Analgesia was not antagonized by naloxone in the hot plate model. Anti-inflammatory activity against carrageenan-induced edema was 60.8 %; however, histamine-induced inflammation was not antogonised by the extract.Conclusions: The extract has some analgesic and anti-inflammatory activities. This justifies its use in traditional medicine for pain of management.Keywords: Viola betonicifolia, Analgesic, Anti-inflammatory

Nursing Students Challenges at Educational and Clinical Environment

Introduction: Nursing students are facing a series of challenges progressively in the clinical practices as well as in education system. The influence of these challenges is on their learning skills. Gape between theoretical leaning and its implementation during the course of training has impact on nursing student’s empowerment. Nursing students have emphasizes on education which taught by preceptor during their training but afterword in their practice and but clinical experience has been totally difference. Nursing students conduct their clinical practice in various kinds of clinical settings. The clinical learning environment is essential for students to most likely accomplish desired learning outcomes.Methods: Descriptive cross sectional study design was used. Study conducted on nursing students and total population for this research work 160 nursing students of Allama Iqbal Medical College at Jinnah Hospital, Lahore.Results: The findings of this research indicated that from the participant’s point of views were follow as, the most important challenge in the educational environment were educator follow traditional ways of teaching in their nursing care (97.1%),no application of theoretical aspects of the nursing process in practice  (69.6%), there is a gap between practice and education system (98.1%), the use of practice were follow as :there is a major difference what they were taught in class is similar what they practice at clinical environment  (95.8%), student not received  constructive feedback from nurse educator/clinical facilitator during accompaniment (96.2%).Conclusions: The gap between the theory and practice was an important finding. Practical-orientation and traditional view of educators, students and nurses about clinical competency based on practical skills that reduced the need of practice based on knowledge and research.  Efforts to reduce the problems between the theory and practice in academic and clinical environment are needed to improve training of student nurses. Also education of professionalism and action based on work environment may be useful. Keywords- Challenges, Nursing students, Educational environment, Clinical environment DOI: 10.7176/JHMN/62-06 Publication date:May 31st 201

Synthesis, structural and antibacterial study of new silver complex with 3-acetyl-2H chromene-2-one

A new silver complex [Ag(C11H8O3)2]NO3 was synthesized by the reaction of silver nitrateand coumarin based ligand (3-acetyl-2H-chromene-2-one) through solution method. The product was characterized using different analytical techniques like melting point, Infrared spectroscopy, Raman spectroscopy, powder X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, atomic absorption spectroscopy and mass spectrometry. An antibacterial study of the complex was also studied for its possible use in medical treatment. KEY WORDS: Silver complex, Acetyl coumarin, Vibrational analysis, Antibacterial study Bull. Chem. Soc. Ethiop. 2016, 30(3), 403-411DOI: http://dx.doi.org/10.4314/bcse.v30i3.

Acute-on-chronic Liver Failure: MELD Score 30-day Mortality Predictability and Etiology in a Pakistani Population

Background: Cirrhosis is a pathological condition that ultimately leads to liver failure. Acute on chronic liver failure (ACLF) has a high short term mortality rate. Viral hepatitis is the most common cause of liver failure in our local population. We carried out this study to identity the 30-day mortality and etiology of patients presenting with ACLF using Model for End-Stage Liver Disease (MELD) score predictability. Methodology: This was a descriptive case series, conducted at Sheikh Zayed Hospital, Lahore, Pakistan from January 31, 2018 to July 30, 2018. One hundred and eighty five patients who met the inclusion criteria were enrolled using 95% confidence level and 4% margin of error. Data was entered and analyzed with SPSS version 23.0. Numerical variables including age was presented by Mean ± S.D. Categorical variables i.e. gender, etiology of acute-on-chronic liver failure and 30-day mortality were presented by frequency and percentage. Data was stratified for age, gender, duration of chronic liver disease and MELD grade to address the effect modifiers. Post-stratification chi-square test was calculated using 95% significance (p≤0.05). Results: Majority of the enrolled patients were male (74.6%) while only 25.4% of the patients were female. One hundred and thirty patients (70.3%) had underlying viral hepatitis while twelve patients (6.5%) and forty three patients (23.2%) presented with alcoholic liver disease and drug-induced ACLF, respectively. Eighty patients (43.2%) died within 30 days of admission.The 30-day mortality with respect to MELD grade was statistically significant (p<0.001) with the highest mortality noted in grade-IV and thirty five patients (43.8%) dying within 30 days of admission (p<0.001). Grade-II and III MELD scores also contributed to the 30-day mortality with twenty three patients (28.8%) and nineteen patients (23.8%) dying within 30 days of admission (p<0.001). Conclusion: MELD scores are able to accurately predict the short-term mortality in patients with ACLF and viral hepatitis was the most common etiology in our population. Early detection and use of appropriate prognostic models may alleviate mortality and morbidity in paitents with ACLF

Quantum algorithms and the power of forgetting

The so-called welded tree problem provides an example of a black-box problem that can be solved exponentially faster by a quantum walk than by any classical algorithm. Given the name of a special ENTRANCE vertex, a quantum walk can find another distinguished EXIT vertex using polynomially many queries, though without finding any particular path from ENTRANCE to EXIT. It has been an open problem for twenty years whether there is an efficient quantum algorithm for finding such a path, or if the path-finding problem is hard even for quantum computers. We show that a natural class of efficient quantum algorithms provably cannot find a path from ENTRANCE to EXIT. Specifically, we consider algorithms that, within each branch of their superposition, always store a set of vertex labels that form a connected subgraph including the ENTRANCE, and that only provide these vertex labels as inputs to the oracle. While this does not rule out the possibility of a quantum algorithm that efficiently finds a path, it is unclear how an algorithm could benefit by deviating from this behavior. Our no-go result suggests that, for some problems, quantum algorithms must necessarily forget the path they take to reach a solution in order to outperform classical computation.Comment: 49 pages, 9 figure

Quantum Algorithms and the Power of Forgetting

The so-called welded tree problem provides an example of a black-box problem that can be solved exponentially faster by a quantum walk than by any classical algorithm [Andrew M. Childs et al., 2003]. Given the name of a special entrance vertex, a quantum walk can find another distinguished exit vertex using polynomially many queries, though without finding any particular path from entrance to exit. It has been an open problem for twenty years whether there is an efficient quantum algorithm for finding such a path, or if the path-finding problem is hard even for quantum computers. We show that a natural class of efficient quantum algorithms provably cannot find a path from entrance to exit. Specifically, we consider algorithms that, within each branch of their superposition, always store a set of vertex labels that form a connected subgraph including the entrance, and that only provide these vertex labels as inputs to the oracle. While this does not rule out the possibility of a quantum algorithm that efficiently finds a path, it is unclear how an algorithm could benefit by deviating from this behavior. Our no-go result suggests that, for some problems, quantum algorithms must necessarily forget the path they take to reach a solution in order to outperform classical computation

AGRICULTURAL WATER MANAGEMENT THROUGH MAGNETIZATION OF IRRIGATION AND DRINKING WATER: A REVIEW

    Received 03 December 2017; Accepted 18 February 2018 *Corresponding Author M. Gholizadeh Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran Email: [email protected] ©This article is open access and licensed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted, use, distribution and reproduction in any medium, or format for any purpose, even commercially provided the work is properly cited. Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. Agricultural water management in arid and semi-arid countries such as Iran is of utmost importance. Alterations of water as a major component of each bio system through magnetization have been reviewed in this study. Magnetization process has been used as green technology in industry and agriculture with controversial results. Properties of water such as pH, hydrogen bonds, temperature, structure and its ions can be affected by an external magnetic field. Subsequent modifications have substantial impacts on water quality that is determined for optimum plant and animal production. There are some reports among numerous studies in agronomy, gardening and animal husbandry which claim fruitful influence of this treatment both qualitatively and quantitatively. Nevertheless, there are some controversial reports on the effects of magnetization. In conclusion, the response of organisms depends on magnetization time and intensity, water quality and plant or animal species. These variables should be taken into account for further studies regarding this mysteries process