The Backreaction of Anti-M2 Branes on a Warped Stenzel Space

We find the superpotential governing the supersymmetric warped M-theory solution with a transverse Stenzel space found by Cvetic, Gibbons, Lu and Pope in hep-th/0012011, and use this superpotential to extract and solve the twelve coupled equations underlying the first-order backreacted solution of a stack of anti-M2 branes in this space. These anti-M2 branes were analyzed recently in a probe approximation by Klebanov and Pufu, who conjectured that they should be dual to a metastable vacuum of a supersymmetric 2+1 dimensional theory. We find that the would-be supergravity dual to such a metastable vacuum must have an infrared singularity and discuss whether this singularity is acceptable or not. Given that a similar singularity appears when placing anti-D3 branes in the Klebanov-Strassler solution, our work strengthens the possibility that anti-branes in warped throats do not give rise to metastable vacua.Comment: 28 pages, LaTe

Robust lineage reconstruction from high-dimensional single-cell data

Single-cell gene expression data provide invaluable resources for systematic characterization of cellular hierarchy in multi-cellular organisms. However, cell lineage reconstruction is still often associated with significant uncertainty due to technological constraints. Such uncertainties have not been taken into account in current methods. We present ECLAIR (Ensemble Cell Lineage Analysis with Improved Robustness), a novel computational method for the statistical inference of cell lineage relationships from single-cell gene expression data. ECLAIR uses an ensemble approach to improve the robustness of lineage predictions, and provides a quantitative estimate of the uncertainty of lineage branchings. We show that the application of ECLAIR to published datasets successfully reconstructs known lineage relationships and significantly improves the robustness of predictions. ECLAIR is a powerful bioinformatics tool for single-cell data analysis. It can be used for robust lineage reconstruction with quantitative estimate of prediction accuracy

Assessing a candidate IIA dual to metastable supersymmetry-breaking

We analyze the space of linearized non-supersymmetric deformations around a IIA solution found by Cvetic, Gibbons, Lu and Pope (CGLP) in hep-th/0101096. We impose boundary conditions aimed at singling out among those perturbations those describing the backreaction of anti-D2 branes on the CGLP background. The corresponding supergravity solution is a would-be dual to a metastable supersymmetry-breaking state. However, it turns out that this candidate bulk solution is inevitably riddled with IR divergences of its flux densities and action, whose physical meaning and implications for models of string cosmology call for further investigation.Comment: 33 pages. v2: reference added, clarifications in the introductio

On Metastable Vacua and the Warped Deformed Conifold: Analytic Results

Continuing the programme of constructing the backreacted solution corresponding to smeared anti-D3 branes in the warped deformed conifold, we solve analytically the equations governing the space of first-order deformations around this solution. We express the results in terms of at most three nested integrals. These are the simplest expressions for the space of SU(2) \times SU(2) \times \ZZ_2-invariant deformations, in which the putative solution for smeared anti-D3 branes must live. We also explain why one cannot claim to identify this solution without fully relating the coefficients of the infrared and ultraviolet expansions of the deformation modes. The analytic solution we find is the first step in this direction.Comment: 16 page

On The Inflaton Potential From Antibranes in Warped Throats

We compute the force between a stack of smeared antibranes at the bottom of a warped throat and a stack of smeared branes at some distance up the throat, both for anti-D3 branes and for anti-M2 branes. We perform this calculation in two ways: first, by treating the antibranes as probes in the background sourced by the branes and second, by treating the branes as probes in the candidate background sourced by the antibranes. These two very different calculations yield exactly the same expression for the force, for all values of the brane-antibrane separation. This indicates that the force between a brane and an antibrane is not screened in backgrounds where there is positive charge dissolved in flux, and gives a way to precisely compute the inflaton potential in certain string cosmology scenarios.Comment: 9 page

The backreaction of anti-D3 branes on the Klebanov-Strassler geometry

We present the full numerical solution for the 15-dimensional space of linearized deformations of the Klebanov-Strassler background which preserve the SU(2) X SU(2) X Z_2 symmetries. We identify within this space the solution corresponding to anti-D3 branes, (modulo the presence of a certain subleading singularity in the infrared). All the 15 integration constants of this solution are fixed in terms of the number of anti-D3 branes, and the solution differs in the UV from the supersymmetric solution into which it is supposed to decay by a mode corresponding to a rescaling of the field theory coordinates. Deciding whether two solutions that differ in the UV by a rescaling mode are dual to the same theory is involved even for supersymmetric Klebanov-Strassler solutions, and we explain in detail some of the subtleties associated to this.Comment: 41 pages, 5 figures, LaTe

Finite-Temperature Fractional D2-Branes and the Deconfinement Transition in 2+1 Dimensions

The supergravity dual to N regular and M fractional D2-branes on the cone over \mathbb{CP}^3 has a naked singularity in the infrared. One can resolve this singularity and obtain a regular fractional D2-brane solution dual to a confining 2+1 dimensional N = 1 supersymmetric field theory. The confining vacuum of this theory is described by the solution of Cvetic, Gibbons, Lu and Pope. In this paper, we explore the alternative possibility for resolving the singularity - the creation of a regular horizon. The black-hole solution we find corresponds to the deconfined phase of this dual gauge theory in three dimensions. This solution is derived in perturbation theory in the number of fractional branes. We argue that there is a first-order deconfinement transition. Connections to Chern--Simons matter theories, the ABJM proposal and fractional M2-branes are presented.Comment: v3: analytic solutions are expose