479 research outputs found
Odd Frequency Pairing in the Kondo Lattice
We discuss the possibility that heavy fermion superconductors involve
odd-frequency pairing of the kind first considered by Berezinskii. Using a toy
model for odd frequency triplet pairing in the Kondo lattice we are able to
examine key properties of this new type of paired state. To make progress
treating the strong constraint in the Kondo lattice model we use the
technical trick of a Majorana representation of the local moments, which
permits variational treatments of the model without a Gutzwiller approximation.
The simplest mean field theory involves the development of bound states between
the local moments and conduction electrons, characterized by a spinor order
parameter. We show that this state is a stable realization of odd frequency
triplet superconductivity with surfaces of gapless excitations whose spin and
charge coherence factors vanish linearly in the quasiparticle energy. A
NMR relaxation rate coexists with a linear specific heat. We discuss possible
extensions of our toy model to describe heavy fermion superconductivity.Comment: 67 page
Non-Coding Changes Cause Sex-Specific Wing Size Differences between Closely Related Species of Nasonia
The genetic basis of morphological differences among species is still poorly understood. We investigated the genetic basis of sex-specific differences in wing size between two closely related species of Nasonia by positional cloning a major male-specific locus, wing-size1 (ws1). Male wing size increases by 45% through cell size and cell number changes when the ws1 allele from N. giraulti is backcrossed into a N. vitripennis genetic background. A positional cloning approach was used to fine-scale map the ws1 locus to a 13.5 kilobase region. This region falls between prospero (a transcription factor involved in neurogenesis) and the master sex-determining gene doublesex. It contains the 5′-UTR and cis-regulatory domain of doublesex, and no coding sequence. Wing size reduction correlates with an increase in doublesex expression level that is specific to developing male wings. Our results indicate that non-coding changes are responsible for recent divergence in sex-specific morphology between two closely related species. We have not yet resolved whether wing size evolution at the ws1 locus is caused by regulatory alterations of dsx or prospero, or by another mechanism. This study demonstrates the feasibility of efficient positional cloning of quantitative trait loci (QTL) involved in a broad array of phenotypic differences among Nasonia species
IEA wind recommended practices for the implementation of wind power forecasting solutions part 2 and 3 : designing and executing forecasting benchmarks and evaluation of forecast solutions
In this paper, we summarize the second and third part of a series of three IEA Recommended Practice documents for the power industry that deal with how to setup and run a trial or benchmark as well as verifying the goodness of forecast solutions. The Recommended Practice is intended to serve as a set of standards that provide guidance for private industry, academics and government for the process of obtaining an optimal forecast solution for specific applications as well as the ongoing evaluation of the performance of the solution to increase the probability that it continues to be an optimal solution as forecast technology evolves. The work is part of the IEA Wind Task 36 on Wind Power Forecasting
Expert Elicitation on Wind Farm Control
Wind farm control is an active and growing field of research in which the
control actions of individual turbines in a farm are coordinated, accounting
for inter-turbine aerodynamic interaction, to improve the overall performance
of the wind farm and to reduce costs. The primary objectives of wind farm
control include increasing power production, reducing turbine loads, and
providing electricity grid support services. Additional objectives include
improving reliability or reducing external impacts to the environment and
communities. In 2019, a European research project (FarmConners) was started
with the main goal of providing an overview of the state-of-the-art in wind
farm control, identifying consensus of research findings, data sets, and best
practices, providing a summary of the main research challenges, and
establishing a roadmap on how to address these challenges. Complementary to the
FarmConners project, an IEA Wind Topical Expert Meeting (TEM) and two rounds of
surveys among experts were performed. From these events we can clearly identify
an interest in more public validation campaigns. Additionally, a deeper
understanding of the mechanical loads and the uncertainties concerning the
effectiveness of wind farm control are considered two major research gaps
Tracking Interacting Objects Optimally Using Integer Programming
In this paper, we show that tracking different kinds of interacting objects can be formulated as a network-flow Mixed Integer Program. This is made possible by tracking all objects simultaneously and expressing the fact that one object can appear or disappear at locations where another is in terms of linear flow constraints. We demonstrate the power of our approach on scenes involving cars and pedestrians, bags being carried and dropped by people, and balls being passed from one player to the next in a basketball game. In particular, we show that by estimating jointly and globally the trajectories of different types of objects, the presence of the ones which were not initially detected based solely on image evidence can be inferred from the detections of the others
What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England.
OBJECTIVES: The aim of this study was to identify the most important determinants of accident and emergency (A&E) attendance in disadvantaged areas. DESIGN, SETTING AND PARTICIPANTS: A total of 3510 residents from 20 disadvantaged neighbourhoods in the North West Coast area in England completed a comprehensive public health survey. MAIN OUTCOME MEASURES: Participants were asked to complete general background information, as well as information about their physical health, mental health, lifestyle, social issues, housing and environment, work and finances, and healthcare service usage. Only one resident per household could take part in the survey. Poisson regression analysis was employed to assess the predictors of A&E attendance frequency in the previous 12 months. RESULTS: 31.6% of the sample reported having attended A&E in the previous 12 months, ranging from 1 to 95 visits. Controlling for demographic and health factors, not being in employment and living in poor quality housing increased the likelihood of attending an A&E service. Service access was also found to be predictive of A&E attendance insofar as there were an additional 18 fewer A&E attendances per 100 population for each kilometre closer a person lived to a general practitioner (GP) practice, and 3 fewer attendances per 100 population for each kilometre further a person lived from an A&E department. CONCLUSIONS: This is one of the first surveys to explore a comprehensive set of socio-economic factors as well as proximity to both GP and A&E services as predictors of A&E attendance in disadvantaged areas. Findings from this study suggest the need to address both socioeconomic issues, such as employment and housing quality, as well as structural issues, such as public transport and access to primary care, to reduce the current burden on A&E departments
Stanowisko polskich ekspertów dotyczące zastosowania leku brentuksymab vedotin w leczeniu chorych na pierwotne chłoniaki skóry CD30+
The group of primary cutaneous T-cell lymphomas (CTCLs) expressing CD30 + is consisted of primary cutaneous anaplastic T-cell lymphoma (pcACTL), lymphomatoid papulosis (LyP), some cases of mycosis fungoides (MF) and Sezary syndrome (SS). It is well known that patient cannot be cured completely by available therapeutic methods. In addition, the effectiveness of available therapies is especially limited in advanced stages of the disease. Based on the results of the most recent trials, the experts recommend that brentuximab vedotin (BV) should be reimbursed in Poland for the treatment of adult patients with CTCL expressing CD30 who have had at least one prior systemic treatment. In case of MF BV should be preferred to bexarotene or MTX therapy due to the higher efficacy in stage IIB or higher. BV treatment should be also considered as an alternative to bexarotene (after ineffectiveness of local treatment, phototherapy and IFN/MTX therapy) in early stages of MF (IB-IIA).Do pierwotnych chÅ‚oniaków skóry T-komórkowych (CTCL) z ekspresjÄ… CD30+ należą pierwotny skórny chÅ‚oniak anaplastyczny z dużych komórek (pcALCL), lymphomatoid papulosis (LyP), a także ziarniniak grzybiasty (MF) i zespół Sézary’ego (SS), spoÅ›ród których u części można stwierdzić ekspresjÄ™ CD30+. IstniejÄ…ce metody terapii nie pozwalajÄ… na wyleczenie pacjenta choÂrujÄ…cego na wymienione wyżej odmiany chÅ‚oniaków. Ponadto skuteczność dostÄ™pnych metod jest szczególnie ograniczona w zaawansowanych stadiach choroby. Na podstawie wyników najnowszych badaÅ„ eksperci rekomendujÄ…, aby brentuksymab vedotin (BV) byÅ‚ dostÄ™pny w Polsce do leczenia doÂrosÅ‚ych pacjentów z CTCL z ekspresjÄ… CD30, u których uprzednio stosowano co najmniej jedno leÂczenie systemowe. W stadium MF IIB i wyższym leczenie BV powinno być preferowane w stosunku do terapii beksarotenem lub metotreksatem (MTX) ze wzglÄ™du na wyższÄ… skuteczność nowego leku. We wczesnych stadiach MF (IB–IIA) należy rozważyć leczenie BV alternatywnie do stosowania bekÂsarotenu (po nieskutecznoÅ›ci leczenia miejscowego, fototerapii i terapii interferonem i/lub MTX). Skuteczność leczenia BV wykazano u chorych z pcALCL zarówno we wczesnej fazie z obecnoÅ›ciÄ… zmian ograniczonych do skóry, jak i w postaci zaawansowanej z pozaskórnÄ… lokalizacjÄ… zmian
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